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Lung Function Decline in Cystic Fibrosis: Impact of Data Availability and Modeling Strategies on Clinical Interpretations.
Szczesniak R, Andrinopoulou ER, Su W, Afonso PM, Burgel PR, Cromwell E, Gecili E, Ghulam E, Goss CH, Mayer-Hamblett N, Keogh RH, Liou TG, Marshall B, Morgan WJ, Ostrenga JS, Pasta DJ, Stanojevic S, Wainwright C, Zhou GC, Fernandez G, Fink AK, Schechter MS. Szczesniak R, et al. Among authors: morgan wj. Ann Am Thorac Soc. 2023 Jul;20(7):958-968. doi: 10.1513/AnnalsATS.202209-829OC. Ann Am Thorac Soc. 2023. PMID: 36884219
Marginal models consistently estimated less rapid lung function decline than mixed-effects models across scenarios, except for short-term follow-up (both were 1.4). Rate of decline estimates from nonlinear models diverged by age 30. ...Conclusions: Differences were as high …
Marginal models consistently estimated less rapid lung function decline than mixed-effects models across scenarios, except for short-term …
Association of Childhood Respiratory Status with Adult Occupational Exposures in a Birth Cohort.
Harber P, Furlong M, Stern DA, Morgan WJ, Wright AL, Guerra S, Martinez FD. Harber P, et al. Among authors: morgan wj. Ann Am Thorac Soc. 2023 Mar;20(3):390-396. doi: 10.1513/AnnalsATS.202204-293OC. Ann Am Thorac Soc. 2023. PMID: 36538681 Free PMC article.
Methods: The TCRS (Tucson Children's Respiratory Study) is a long-term prospective study of respiratory health beginning at birth. ...
Methods: The TCRS (Tucson Children's Respiratory Study) is a long-term prospective study of respiratory health beginning at birth …
Protective effect of breastfeeding on recurrent cough in adulthood.
Gerhart KD, Stern DA, Guerra S, Morgan WJ, Martinez FD, Wright AL. Gerhart KD, et al. Among authors: morgan wj. Thorax. 2018 Sep;73(9):833-839. doi: 10.1136/thoraxjnl-2017-210841. Epub 2018 May 21. Thorax. 2018. PMID: 29786547 Free PMC article.
METHODS: Infant feeding practices were assessed prospectively in the Tucson Children's Respiratory Study, a non-selected birth cohort and categorised into formula from birth or introduced <1 month, formula introduced 1 to <4 months and exclusive breastfeeding …
METHODS: Infant feeding practices were assessed prospectively in the Tucson Children's Respiratory Study, a non-selected birth cohort …
Association of High-Dose Ibuprofen Use, Lung Function Decline, and Long-Term Survival in Children with Cystic Fibrosis.
Konstan MW, VanDevanter DR, Sawicki GS, Pasta DJ, Foreman AJ, Neiman EA, Morgan WJ. Konstan MW, et al. Among authors: morgan wj. Ann Am Thorac Soc. 2018 Apr;15(4):485-493. doi: 10.1513/AnnalsATS.201706-486OC. Ann Am Thorac Soc. 2018. PMID: 29313709
CONCLUSIONS: In a propensity-score matched cohort study of children with cystic fibrosis, we observed an association between high-dose ibuprofen use and both slower lung function decline and improved long-term survival. These results are consistent with the hypothesis that …
CONCLUSIONS: In a propensity-score matched cohort study of children with cystic fibrosis, we observed an association between high-dose ibupr …
Association of prenatal and early childhood stress with reduced lung function in 7-year-olds.
Lee AG, Chiu YM, Rosa MJ, Cohen S, Coull BA, Wright RO, Morgan WJ, Wright RJ. Lee AG, et al. Among authors: morgan wj. Ann Allergy Asthma Immunol. 2017 Aug;119(2):153-159. doi: 10.1016/j.anai.2017.05.025. Epub 2017 Jun 28. Ann Allergy Asthma Immunol. 2017. PMID: 28668548 Free PMC article.
In sex-stratified analyses, high postnatal stress (5 NLEs) was associated with lower FEV(1) (z score = -0.76, P = .01), FVC (z score = -0.77, P = .01), and FEF(25%-75%) (z score = -0.67, P = .02) in boys but not girls, although the interaction term was not significant (P f …
In sex-stratified analyses, high postnatal stress (5 NLEs) was associated with lower FEV(1) (z score = -0.76, P = .01), FVC (z score = -0.77 …
Pulmonary exacerbations in cystic fibrosis: young children with characteristic signs and symptoms.
Regelmann WE, Schechter MS, Wagener JS, Morgan WJ, Pasta DJ, Elkin EP, Konstan MW; Investigators of the Epidemiologic Study of Cystic Fibrosis. Regelmann WE, et al. Among authors: morgan wj. Pediatr Pulmonol. 2013 Jul;48(7):649-57. doi: 10.1002/ppul.22658. Epub 2012 Sep 4. Pediatr Pulmonol. 2013. PMID: 22949088 Free PMC article.
The presence of these four characteristic signs and symptoms is useful to define pulmonary exacerbations in young children with CF that respond to antibiotic treatment in the short-term and influence long-term prognosis....
The presence of these four characteristic signs and symptoms is useful to define pulmonary exacerbations in young children with CF that resp …
Oral, inhaled, and intravenous antibiotic choice for treating pulmonary exacerbations in cystic fibrosis.
Wagener JS, Rasouliyan L, VanDevanter DR, Pasta DJ, Regelmann WE, Morgan WJ, Konstan MW; Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis. Wagener JS, et al. Among authors: morgan wj. Pediatr Pulmonol. 2013 Jul;48(7):666-73. doi: 10.1002/ppul.22652. Epub 2012 Aug 8. Pediatr Pulmonol. 2013. PMID: 22888106 Free PMC article.
METHODS: We used 2003-2005 data from the Epidemiologic Study of Cystic Fibrosis to examine antibiotic treatment and the immediate and long-term lung function change associated with clinician reported PExs. ...
METHODS: We used 2003-2005 data from the Epidemiologic Study of Cystic Fibrosis to examine antibiotic treatment and the immediate and long- …
Long-term outcomes of early-onset wheeze and asthma.
Grad R, Morgan WJ. Grad R, et al. Among authors: morgan wj. J Allergy Clin Immunol. 2012 Aug;130(2):299-307. doi: 10.1016/j.jaci.2012.05.022. Epub 2012 Jun 26. J Allergy Clin Immunol. 2012. PMID: 22738675 Free PMC article. Review.
Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial.
Sorkness CA, Lemanske RF Jr, Mauger DT, Boehmer SJ, Chinchilli VM, Martinez FD, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Bloomberg GR, Covar RA, Guilbert TW, Heldt G, Larsen G, Mellon MH, Morgan WJ, Moss MH, Spahn JD, Taussig LM; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Sorkness CA, et al. Among authors: morgan wj. J Allergy Clin Immunol. 2007 Jan;119(1):64-72. doi: 10.1016/j.jaci.2006.09.042. Epub 2006 Nov 30. J Allergy Clin Immunol. 2007. PMID: 17140647 Clinical Trial.
Long-term inhaled corticosteroids in preschool children at high risk for asthma.
Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ, Bacharier LB, Lemanske RF Jr, Strunk RC, Allen DB, Bloomberg GR, Heldt G, Krawiec M, Larsen G, Liu AH, Chinchilli VM, Sorkness CA, Taussig LM, Martinez FD. Guilbert TW, et al. Among authors: morgan wj. N Engl J Med. 2006 May 11;354(19):1985-97. doi: 10.1056/NEJMoa051378. N Engl J Med. 2006. PMID: 16687711 Free article. Clinical Trial.
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