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Luteinizing hormone-releasing hormone agonists in the treatment of prostate cancer: a review of their discovery, development, and place in therapy.
Clin Ther. 2006 Oct;28(10):1485-508. doi: 10.1016/j.clinthera.2006.10.018.
Clin Ther. 2006.
PMID: 17157109
Review.
Several prospective randomized trials have reported decreases in rates of positive surgical margins with short-term (6 weeks to 4 months) neoadjuvant LHRH-agonist therapy in patients with stage T1 to T3a PC undergoing prostatectomy. ...However, the results of several studi …
Several prospective randomized trials have reported decreases in rates of positive surgical margins with short-term (6 weeks to 4 mon …
BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide.
Jaquet P, Gunz G, Saveanu A, Barlier A, Dufour H, Taylor J, Dong J, Kim S, Moreau JP, Culler MD.
Jaquet P, et al. Among authors: moreau jp.
J Endocrinol Invest. 2005;28(11 Suppl International):21-7.
J Endocrinol Invest. 2005.
PMID: 16625841
We report the comparative efficacy of a somatostatin receptor 1 and 5 subtypes (SSTR2 and SSTR5), and dopamine D2 (DAD2) compound, BIM-23A760, in suppressing GH secretion, in cell culture from human GH-secreting tumors, from patients partially responsive to long-term treat …
We report the comparative efficacy of a somatostatin receptor 1 and 5 subtypes (SSTR2 and SSTR5), and dopamine D2 (DAD2) compound, BIM-23A76 …
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Response of human lung tumor xenografts to treatment with a somatostatin analogue (Somatuline).
Bogden AE, Taylor JE, Moreau JP, Coy DH, LePage DJ.
Bogden AE, et al. Among authors: moreau jp.
Cancer Res. 1990 Jul 15;50(14):4360-5.
Cancer Res. 1990.
PMID: 1973071
Absence of observable systemic or local toxicity during prolonged treatment would support this conclusion and suggest the feasibility of long term maintenance therapy with a resultant extended survival....
Absence of observable systemic or local toxicity during prolonged treatment would support this conclusion and suggest the feasibility of lon …
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