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Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity.
Hill E, Karikari TK, Moffat KG, Richardson MJE, Wall MJ. Hill E, et al. Among authors: moffat kg. eNeuro. 2019 Oct 15;6(5):ENEURO.0166-19.2019. doi: 10.1523/ENEURO.0166-19.2019. Print 2019 Sep/Oct. eNeuro. 2019. PMID: 31554666 Free PMC article.
Here, whole-cell patch clamp recording was used to introduce known concentrations of oligomeric full-length tau-441 into mouse hippocampal CA1 pyramidal and neocortical Layer V thick-tufted pyramidal cells. oTau increased input resistance, reduced action potential amplitude and s …
Here, whole-cell patch clamp recording was used to introduce known concentrations of oligomeric full-length tau-441 into mouse hippocampal C …