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Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis.
Mobbs CV, Isoda F, Makimura H, Mastaitis J, Mizuno T, Shu IW, Yen K, Yang XJ. Mobbs CV, et al. Physiol Behav. 2005 May 19;85(1):3-23. doi: 10.1016/j.physbeh.2005.04.005. Physiol Behav. 2005. PMID: 15924903 Review.
Since leptin is not a physiological satiety factor (because it does not increase before meal termination), yet leptin deficiency causes obesity, we suggest that the glucostatic hypothesis be re-formulated without reference to satiety (i.e., short-term effects on food intak …
Since leptin is not a physiological satiety factor (because it does not increase before meal termination), yet leptin deficiency causes obes …
Effects of tumor necrosis factor alpha on leptin secretion and gene expression: relationship to changes of glucose metabolism in isolated rat adipocytes.
Medina EA, Stanhope KL, Mizuno TM, Mobbs CV, Gregoire F, Hubbard NE, Erickson KL, Havel PJ. Medina EA, et al. Among authors: mobbs cv. Int J Obes Relat Metab Disord. 1999 Aug;23(8):896-903. doi: 10.1038/sj.ijo.0800970. Int J Obes Relat Metab Disord. 1999. PMID: 10490793
Overall, for the TNF-alpha concentrations tested, leptin secretion was inversely related to the percent of glucose carbon released as lactate; however, TNF-alpha did not induce a proportional increase of lactate production from glucose. CONCLUSION: Short-term (24 h) exposu …
Overall, for the TNF-alpha concentrations tested, leptin secretion was inversely related to the percent of glucose carbon released as lactat …
Injection with gold thioglucose impairs sensitivity to glucose: evidence that glucose-responsive neurons are important for long-term regulation of body weight.
Bergen HT, Monkman N, Mobbs CV. Bergen HT, et al. Among authors: mobbs cv. Brain Res. 1996 Sep 23;734(1-2):332-6. Brain Res. 1996. PMID: 8896843
It has been proposed, but never demonstrated, that glucose-responsive neurons are essential for the long-term regulation of body weight, and that mice injected with gold-thio-glucose (GTG) become obese due to destruction of glucose-responsive neurons. ...These data indicat …
It has been proposed, but never demonstrated, that glucose-responsive neurons are essential for the long-term regulation of body weig …
Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector.
Kaplitt MG, Kwong AD, Kleopoulos SP, Mobbs CV, Rabkin SD, Pfaff DW. Kaplitt MG, et al. Among authors: mobbs cv. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8979-83. doi: 10.1073/pnas.91.19.8979. Proc Natl Acad Sci U S A. 1994. PMID: 8090756 Free PMC article.
These results, from the direct gene transfer into an adult animal brain for in vivo promoter analysis, demonstrate that sequence information that influences restricted expression of preproenkephalin is located within 2.7 kb upstream of transcriptional initiation. lacZ expression …
These results, from the direct gene transfer into an adult animal brain for in vivo promoter analysis, demonstrate that sequence information …
Estrogen receptor messenger RNA expression in rat hypothalamus as a function of genetic sex and estrogen dose.
Lauber AH, Mobbs CV, Muramatsu M, Pfaff DW. Lauber AH, et al. Among authors: mobbs cv. Endocrinology. 1991 Dec;129(6):3180-6. doi: 10.1210/endo-129-6-3180. Endocrinology. 1991. PMID: 1954897
Here, we examined whether the level of ER mRNA remains depressed in the continued long-term presence of estradiol, and questioned if there is a systematic relationship between the concentration of estradiol and the decrease in ER mRNA level. ...
Here, we examined whether the level of ER mRNA remains depressed in the continued long-term presence of estradiol, and questioned if …
Pituitary and hypothalamic glucose-6-phosphate dehydrogenase: effects of estradiol and age in C57BL/6J mice.
Gordon MN, Mobbs CV, Finch CE. Gordon MN, et al. Among authors: mobbs cv. Endocrinology. 1988 Feb;122(2):726-33. doi: 10.1210/endo-122-2-726. Endocrinology. 1988. PMID: 3338416
This increase in activity is ovary dependent, because it can be prevented by long term (12-month) ovariectomy. The increased activity is not linked to pituitary tumorigenesis and does not result from trapped blood cells, as evaluated by studies with 51Cr-labeled erythrocyt …
This increase in activity is ovary dependent, because it can be prevented by long term (12-month) ovariectomy. The increased activity …
Estradiol-induced adult anovulatory syndrome in female C57BL/6J mice: age-like neuroendocrine, but not ovarian, impairments.
Mobbs CV, Flurkey K, Gee DM, Yamamoto K, Sinha YN, Finch CE. Mobbs CV, et al. Biol Reprod. 1984 Apr;30(3):556-63. doi: 10.1095/biolreprod30.3.556. Biol Reprod. 1984. PMID: 6539132
Long-term effects of elevated plasma estradiol (E2) on ovarian and neuroendocrine functions were examined in 4-month-old cycling female C57BL/6J mice injected s.c. with 0.2 or 0.05 mg estradiol valerate (EV), or oil. ...
Long-term effects of elevated plasma estradiol (E2) on ovarian and neuroendocrine functions were examined in 4-month-old cycling fema …
Ovarian and steroidal influences on neuroendocrine aging processes in female rodents.
Finch CE, Felicio LS, Mobbs CV, Nelson JF. Finch CE, et al. Among authors: mobbs cv. Endocr Rev. 1984 Fall;5(4):467-97. doi: 10.1210/edrv-5-4-467. Endocr Rev. 1984. PMID: 6389107 Review.
In view of the long lasting effects of E2 and other steroids on lower mammals, the potential for long term effects of ovarian steroids on the human brain and pituitary warrants continued evaluation....
In view of the long lasting effects of E2 and other steroids on lower mammals, the potential for long term effects of ovarian steroid …