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Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1.
Okawa F, Hama Y, Zhang S, Morishita H, Yamamoto H, Levine TP, Mizushima N. Okawa F, et al. Among authors: mizushima n. J Cell Sci. 2021 Apr 15;134(8):jcs255877. doi: 10.1242/jcs.255877. Epub 2021 Apr 28. J Cell Sci. 2021. PMID: 33771928
Phylogenetic analysis reveals that the TMEM41, VMP1, DedA and PF06695 families form a superfamily with a common origin, which we term the DedA superfamily. Coevolution-based structural prediction suggests that the DedA domain contains two reentrant loops facing each other …
Phylogenetic analysis reveals that the TMEM41, VMP1, DedA and PF06695 families form a superfamily with a common origin, which we term …
Should I bend or should I grow: the mechanisms of droplet-mediated autophagosome formation.
Schultz SW, Agudo-Canalejo J, Chino H, Migliano SM, Saito C, Koyama-Honda I, Stenmark H, Brech A, Mizushima N, Knorr RL, May AI. Schultz SW, et al. Among authors: mizushima n. Autophagy. 2021 Apr;17(4):1046-1048. doi: 10.1080/15548627.2021.1887548. Epub 2021 Feb 25. Autophagy. 2021. PMID: 33629888 Free PMC article.
We found that the competition between droplet surface tension and the increasing tendency of growing membrane sheets to bend determines whether a droplet is completely engulfed or isolated in a piecemeal fashion, a process we term fluidophagy. Intriguingly, we found that a …
We found that the competition between droplet surface tension and the increasing tendency of growing membrane sheets to bend determines whet …
LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells.
Jiang P, Mizushima N. Jiang P, et al. Among authors: mizushima n. Methods. 2015 Mar;75:13-8. doi: 10.1016/j.ymeth.2014.11.021. Epub 2014 Dec 5. Methods. 2015. PMID: 25484342
However, autophagy involves dynamic and complicated processes that make it difficult to analyze. The term "autophagic flux" is used to denote overall autophagic degradation (i.e., delivery of autophagic cargo to the lysosome) rather than autophagosome formation. ...
However, autophagy involves dynamic and complicated processes that make it difficult to analyze. The term "autophagic flux" is used t …
Inhibition of autophagy in the heart induces age-related cardiomyopathy.
Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I, Oka T, Tamai T, Oyabu J, Murakawa T, Nishida K, Shimizu T, Hori M, Komuro I, Takuji Shirasawa TS, Mizushima N, Otsu K. Taneike M, et al. Among authors: mizushima n. Autophagy. 2010 Jul;6(5):600-6. doi: 10.4161/auto.6.5.11947. Epub 2010 Jul 1. Autophagy. 2010. PMID: 20431347
We have previously reported that cardiac-specific Atg5 (autophagy-related gene 5)-deficient mice, in which the gene was floxed out early in embryogenesis, were born normally, and showed normal cardiac function and structure up to 10 weeks old. In the present study, to determine t …
We have previously reported that cardiac-specific Atg5 (autophagy-related gene 5)-deficient mice, in which the gene was floxed out early in …
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Degterev A, et al. Among authors: mizushima n. Nat Chem Biol. 2005 Jul;1(2):112-9. doi: 10.1038/nchembio711. Epub 2005 May 29. Nat Chem Biol. 2005. PMID: 16408008
Although stimulation of the Fas/TNFR receptor family triggers a canonical 'extrinsic' apoptosis pathway, we demonstrated that in the absence of intracellular apoptotic signaling it is capable of activating a common nonapoptotic death pathway, which we term necroptosis. We …
Although stimulation of the Fas/TNFR receptor family triggers a canonical 'extrinsic' apoptosis pathway, we demonstrated that in the absence …
Deafness following mumps: the possible pathogenesis and incidence of deafness.
Mizushima N, Murakami Y. Mizushima N, et al. Auris Nasus Larynx. 1986;13 Suppl 1:S55-7. doi: 10.1016/s0385-8146(86)80035-9. Auris Nasus Larynx. 1986. PMID: 3767776
An analysis of the present series of mumps deafness also suggests that the primary route of invasion of the virus is hematogenous, and thus the term "viral endolymphatic labyrinthitis" is proposed as the possible pathogenesis of the deafness, since both tympanogenic and me …
An analysis of the present series of mumps deafness also suggests that the primary route of invasion of the virus is hematogenous, and thus …