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Diversity and disease pathogenesis in Mycobacterium tuberculosis.
Warner DF, Koch A, Mizrahi V. Warner DF, et al. Among authors: mizrahi v. Trends Microbiol. 2015 Jan;23(1):14-21. doi: 10.1016/j.tim.2014.10.005. Epub 2014 Nov 10. Trends Microbiol. 2015. PMID: 25468790 Review.
The increasing availability of whole-genome sequence (WGS) data for Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB), suggests that circulating genotypes have been molded by three dominant evolutionary forces: long-term persistence within the human p …
The increasing availability of whole-genome sequence (WGS) data for Mycobacterium tuberculosis, the bacterium that causes tuberculosis (TB), …
Resuscitation-promoting factors as lytic enzymes for bacterial growth and signaling.
Kana BD, Mizrahi V. Kana BD, et al. Among authors: mizrahi v. FEMS Immunol Med Microbiol. 2010 Feb;58(1):39-50. doi: 10.1111/j.1574-695X.2009.00606.x. Epub 2009 Sep 4. FEMS Immunol Med Microbiol. 2010. PMID: 19799629 Free article. Review.
Clearly, a deeper understanding of the role of Rpfs and associated peptidoglycan remodeling enzymes in bacterial growth and culturability is necessary to establish the significance of dormancy and resuscitation in diseases such as tuberculosis, which are associated with long-t …
Clearly, a deeper understanding of the role of Rpfs and associated peptidoglycan remodeling enzymes in bacterial growth and culturability is …
The carbon starvation-inducible genes Rv2557 and Rv2558 of Mycobacterium tuberculosis are not required for long-term survival under carbon starvation and for virulence in SCID mice.
Gordhan BG, Smith DA, Kana BD, Bancroft G, Mizrahi V. Gordhan BG, et al. Among authors: mizrahi v. Tuberculosis (Edinb). 2006 Nov;86(6):430-7. doi: 10.1016/j.tube.2005.11.001. Epub 2005 Dec 22. Tuberculosis (Edinb). 2006. PMID: 16376615
Although highly induced by carbon starvation, loss of Rv2557 and/or Rv2558 affected neither the long-term survival of M. tuberculosis under carbon-starved conditions in vitro, nor its virulence in SCID mice....
Although highly induced by carbon starvation, loss of Rv2557 and/or Rv2558 affected neither the long-term survival of M. tuberculosis …
Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro.
Downing KJ, Mischenko VV, Shleeva MO, Young DI, Young M, Kaprelyants AS, Apt AS, Mizrahi V. Downing KJ, et al. Among authors: mizrahi v. Infect Immun. 2005 May;73(5):3038-43. doi: 10.1128/IAI.73.5.3038-3043.2005. Infect Immun. 2005. PMID: 15845511 Free PMC article.
The deletion of individual rpf-like genes had no discernible effect on the growth or long-term survival of M. tuberculosis in liquid culture, and the ability to resuscitate spontaneously from a nonculturable state in a most probable number assay was also unaffected for the …
The deletion of individual rpf-like genes had no discernible effect on the growth or long-term survival of M. tuberculosis in liquid …
The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice.
Dahl JL, Kraus CN, Boshoff HI, Doan B, Foley K, Avarbock D, Kaplan G, Mizrahi V, Rubin H, Barry CE 3rd. Dahl JL, et al. Among authors: mizrahi v. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10026-31. doi: 10.1073/pnas.1631248100. Epub 2003 Aug 1. Proc Natl Acad Sci U S A. 2003. PMID: 12897239 Free PMC article.
Long-term survival of nonreplicating Mycobacterium tuberculosis (Mtb) is ensured by the coordinated shutdown of active metabolism through a broad transcriptional program called the stringent response. In Mtb, this response is initiated by the enzymatic action of RelMtb and …
Long-term survival of nonreplicating Mycobacterium tuberculosis (Mtb) is ensured by the coordinated shutdown of active metabolism thr …
The stringent response of Mycobacterium tuberculosis is required for long-term survival.
Primm TP, Andersen SJ, Mizrahi V, Avarbock D, Rubin H, Barry CE 3rd. Primm TP, et al. Among authors: mizrahi v. J Bacteriol. 2000 Sep;182(17):4889-98. doi: 10.1128/JB.182.17.4889-4898.2000. J Bacteriol. 2000. PMID: 10940033 Free PMC article.
The stringent response utilizes hyperphosphorylated guanine [(p)ppGpp] as a signaling molecule to control bacterial gene expression involved in long-term survival under starvation conditions. In gram-negative bacteria, (p)ppGpp is produced by the activity of the related Re …
The stringent response utilizes hyperphosphorylated guanine [(p)ppGpp] as a signaling molecule to control bacterial gene expression involved …