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Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT.
Senjo H, Harada S, Kubota SI, Tanaka Y, Tateno T, Zhang Z, Okada S, Chen X, Kikuchi R, Miyashita N, Onozawa M, Goto H, Endo T, Hasegawa Y, Ohigashi H, Ara T, Hasegawa Y, Murakami M, Teshima T, Hashimoto D. Senjo H, et al. Among authors: miyashita n. Blood. 2023 Aug 3;142(5):477-492. doi: 10.1182/blood.2023019875. Blood. 2023. PMID: 37216687
Calcineurin inhibitor-based graft-versus-host disease (GVHD) prophylaxis is standard in allogeneic hematopoietic stem cell transplantation (HCT) but fails to induce long-term tolerance without chronic GVHD (cGVHD) in a considerable number of patients. ...
Calcineurin inhibitor-based graft-versus-host disease (GVHD) prophylaxis is standard in allogeneic hematopoietic stem cell transplantation ( …
[Bing-Neel syndrome successfully treated with tirabrutinib].
Yokoyama K, Ohigashi H, Miyajima T, Miyashita N, Okada S, Hasegawa Y, Sugita J, Onozawa M, Hashimoto D, Teshima T. Yokoyama K, et al. Among authors: miyashita n. Rinsho Ketsueki. 2022;63(8):870-875. doi: 10.11406/rinketsu.63.870. Rinsho Ketsueki. 2022. PMID: 36058857 Japanese.
Oral administration of tirabrutinib, which was recently approved for WM, began in August 2020. He has achieved long-term remission and steroid withdrawal, with no notable side effects. ...
Oral administration of tirabrutinib, which was recently approved for WM, began in August 2020. He has achieved long-term remission an …
An MFN2-related Charcot-Marie-Tooth Disease Patient with Optic Nerve Atrophy, Neurogenic Bladder Dysfunction, and Diaphragmatic Weakness.
Kimura Y, Nishikawa A, Hashiguchi A, Etoh M, Yoshimura A, Asai K, Miyashita N, Takashima H, Sumi H, Naka T. Kimura Y, et al. Among authors: miyashita n. Intern Med. 2022 Jun 1;61(11):1743-1747. doi: 10.2169/internalmedicine.6487-20. Epub 2021 Nov 20. Intern Med. 2022. PMID: 34803088 Free PMC article.
Our case expands the clinico-genetic features of MFN2-related CMT and highlights the need to evaluate infrequent manifestations during long-term care of CMT patients....
Our case expands the clinico-genetic features of MFN2-related CMT and highlights the need to evaluate infrequent manifestations during long- …
Short-term treatment with imetelstat sensitizes hematopoietic malignant cells to a genotoxic agent via suppression of the telomerase-mediated DNA repair process.
Hidaka D, Onozawa M, Miyashita N, Yokoyama S, Nakagawa M, Hashimoto D, Teshima T. Hidaka D, et al. Among authors: miyashita n. Leuk Lymphoma. 2020 Nov;61(11):2722-2732. doi: 10.1080/10428194.2020.1779256. Epub 2020 Jun 22. Leuk Lymphoma. 2020. PMID: 32571117
Imetelstat enhanced growth inhibitory effect of cytotoxic agents in short-term culture without shortening of telomeres, indicating that this effect was attributed by telomere length independent mechanism. Our results suggest that the combination of short-term treatm …
Imetelstat enhanced growth inhibitory effect of cytotoxic agents in short-term culture without shortening of telomeres, indicating th …
Chronic vitamin C deficiency does not accelerate oxidative stress in ageing brains of guinea pigs.
Tveden-Nyborg P, Hasselholt S, Miyashita N, Moos T, Poulsen HE, Lykkesfeldt J. Tveden-Nyborg P, et al. Among authors: miyashita n. Basic Clin Pharmacol Toxicol. 2012 Jun;110(6):524-9. doi: 10.1111/j.1742-7843.2011.00852.x. Epub 2012 Jan 20. Basic Clin Pharmacol Toxicol. 2012. PMID: 22212866 Free article.
The present study compared oxidative stress of ageing to that of a long-term non-scorbutic vitamin C deficiency in guinea pigs. Adults (3-9 months old) were compared to old (36-42 months old) animals during a 6-month dietary intervention by assessing vitamin C transport an …
The present study compared oxidative stress of ageing to that of a long-term non-scorbutic vitamin C deficiency in guinea pigs. Adult …
[Appropriate antibiotic use for the respiratory tract infections].
Miyashita N. Miyashita N. Yakugaku Zasshi. 2011;131(10):1415-21. doi: 10.1248/yakushi.131.1415. Yakugaku Zasshi. 2011. PMID: 21963967 Free article. Japanese.
The basic policy and main purposes of the JRS guidelines include; 1) prevention of bacterial resistance and 2) effective and long-term use of medical resources. The JRS guidelines have recommended the exclusion of potential and broad spectrum antibiotics from the list of f …
The basic policy and main purposes of the JRS guidelines include; 1) prevention of bacterial resistance and 2) effective and long-term …
The JRS guidelines for the management of community-acquired pneumonia in adults: an update and new recommendations.
Miyashita N, Matsushima T, Oka M, Japanese Respiratory Society. Miyashita N, et al. Intern Med. 2006;45(7):419-28. doi: 10.2169/internalmedicine.45.1691. Epub 2006 May 1. Intern Med. 2006. PMID: 16679695 Free article.
The basic policy and main purposes of the JRS guidelines include; 1) prevention of bacterial resistance and 2) effective and long-term use of medical resources. The JRS guidelines have recommended the exclusion of potential and broad spectrum antibiotics, fluoroquinolones …
The basic policy and main purposes of the JRS guidelines include; 1) prevention of bacterial resistance and 2) effective and long-term …
Outbreak of Chlamydophila pneumoniae infection in long-term care facilities and an affiliated hospital.
Miyashita N, Ouchi K, Shoji H, Obase Y, Fukuda M, Yoshida K, Niki Y, Oka M. Miyashita N, et al. J Med Microbiol. 2005 Dec;54(Pt 12):1243-1247. doi: 10.1099/jmm.0.46191-0. J Med Microbiol. 2005. PMID: 16278441
This paper reports an outbreak of Chlamydophila pneumoniae infection in long-term care facilities and an affiliated hospital. The outbreak involved rapid spread of infection, and was inconsistent with several outbreaks experienced among younger populations. ...Our findings …
This paper reports an outbreak of Chlamydophila pneumoniae infection in long-term care facilities and an affiliated hospital. The out …
Seroepidemiology of Chlamydia pneumoniae in Japan between 1991 and 2000.
Miyashita N, Fukano H, Yoshida K, Niki Y, Matsushima T. Miyashita N, et al. J Clin Pathol. 2002 Feb;55(2):115-7. doi: 10.1136/jcp.55.2.115. J Clin Pathol. 2002. PMID: 11865005 Free PMC article.
CONCLUSIONS: Chlamydia pneumoniae infection is highly endemic in Japan, as it is in Western countries, and there is a year to year variability. Long term studies in Japan are needed to clarify the epidemic occurrence of C pneumoniae infection....
CONCLUSIONS: Chlamydia pneumoniae infection is highly endemic in Japan, as it is in Western countries, and there is a year to year variabili …
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