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Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
Golebiewska A, Hau AC, Oudin A, Stieber D, Yabo YA, Baus V, Barthelemy V, Klein E, Bougnaud S, Keunen O, Wantz M, Michelucci A, Neirinckx V, Muller A, Kaoma T, Nazarov PV, Azuaje F, De Falco A, Flies B, Richart L, Poovathingal S, Arns T, Grzyb K, Mock A, Herold-Mende C, Steino A, Brown D, May P, Miletic H, Malta TM, Noushmehr H, Kwon YJ, Jahn W, Klink B, Tanner G, Stead LF, Mittelbronn M, Skupin A, Hertel F, Bjerkvig R, Niclou SP. Golebiewska A, et al. Among authors: mittelbronn m. Acta Neuropathol. 2020 Dec;140(6):919-949. doi: 10.1007/s00401-020-02226-7. Epub 2020 Oct 3. Acta Neuropathol. 2020. PMID: 33009951 Free PMC article.
We report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, including gliomas with mutations in IDH1, and paired longitudinal PDOX from primary and recurrent tumors of the same patient. We show that g …
We report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, …
Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis.
Antonietti P, Linder B, Hehlgans S, Mildenberger IC, Burger MC, Fulda S, Steinbach JP, Gessler F, Rödel F, Mittelbronn M, Kögel D. Antonietti P, et al. Among authors: mittelbronn m. Mol Cancer Ther. 2017 Jan;16(1):156-168. doi: 10.1158/1535-7163.MCT-16-0262. Epub 2016 Oct 24. Mol Cancer Ther. 2017. PMID: 27777286
Furthermore, it reduced the plating efficiency of U251 cells in three-dimensional clonogenic assays and limited clonogenic survival after short-term treatment with AT-101. Collectively, our data suggest that the HSF1/HSP70/BAG3 pathway plays a pivotal role for overexpressi …
Furthermore, it reduced the plating efficiency of U251 cells in three-dimensional clonogenic assays and limited clonogenic survival after sh …
The angiogenic switch leads to a metabolic shift in human glioblastoma.
Talasila KM, Røsland GV, Hagland HR, Eskilsson E, Flønes IH, Fritah S, Azuaje F, Atai N, Harter PN, Mittelbronn M, Andersen M, Joseph JV, Hossain JA, Vallar L, Noorden CJ, Niclou SP, Thorsen F, Tronstad KJ, Tzoulis C, Bjerkvig R, Miletic H. Talasila KM, et al. Among authors: mittelbronn m. Neuro Oncol. 2017 Mar 1;19(3):383-393. doi: 10.1093/neuonc/now175. Neuro Oncol. 2017. PMID: 27591677 Free PMC article.
In vitro hypoxia experiments additionally revealed metabolic adaptation of invasive tumor cells, which increased lactate production under long-term hypoxia. CONCLUSIONS: The use of glycolysis versus mitochondrial respiration for energy production within human GBM tumors is …
In vitro hypoxia experiments additionally revealed metabolic adaptation of invasive tumor cells, which increased lactate production under lo …
Risk of long-term anticoagulation under sustained severe arterial hypertension: A translational study comparing warfarin and the new oral anticoagulant apixaban.
Pfeilschifter W, Steinstraesser T, Paulus P, Zeiner PS, Bohmann F, Theisen A, Lindhoff-Last E, Penski C, Wagner M, Mittelbronn M, Foerch C. Pfeilschifter W, et al. Among authors: mittelbronn m. J Cereb Blood Flow Metab. 2017 Mar;37(3):855-865. doi: 10.1177/0271678X16642443. Epub 2016 Jul 20. J Cereb Blood Flow Metab. 2017. PMID: 27189904 Free PMC article.
New oral anticoagulants for the prevention of stroke and systemic embolism in patients with atrial fibrillation have recently been introduced. In this translational study, we explored the risk of long-term anticoagulation on intracerebral hemorrhage under sustained severe …
New oral anticoagulants for the prevention of stroke and systemic embolism in patients with atrial fibrillation have recently been introduce …
ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma.
Zhang C, Burger MC, Jennewein L, Genßler S, Schönfeld K, Zeiner P, Hattingen E, Harter PN, Mittelbronn M, Tonn T, Steinbach JP, Wels WS. Zhang C, et al. Among authors: mittelbronn m. J Natl Cancer Inst. 2015 Dec 6;108(5). doi: 10.1093/jnci/djv375. Print 2016 May. J Natl Cancer Inst. 2015. PMID: 26640245
In immunocompetent mice, local therapy with NK-92/5.28.z cells resulted in cures of transplanted syngeneic GBM in four of five mice carrying subcutaneous tumors and five of eight mice carrying intracranial tumors, induction of endogenous antitumor immunity, and long-term p …
In immunocompetent mice, local therapy with NK-92/5.28.z cells resulted in cures of transplanted syngeneic GBM in four of five mice carrying …
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma.
Reuss DE, Sahm F, Schrimpf D, Wiestler B, Capper D, Koelsche C, Schweizer L, Korshunov A, Jones DT, Hovestadt V, Mittelbronn M, Schittenhelm J, Herold-Mende C, Unterberg A, Platten M, Weller M, Wick W, Pfister SM, von Deimling A. Reuss DE, et al. Among authors: mittelbronn m. Acta Neuropathol. 2015 Jan;129(1):133-46. doi: 10.1007/s00401-014-1370-3. Epub 2014 Nov 27. Acta Neuropathol. 2015. PMID: 25427834 Free article.
In a subset of 100 diffuse gliomas from the NOA-04 trial with long-term follow-up data available, the "integrated" diagnosis had a significantly greater prognostic power for overall and progression-free survival compared to WHO 2007. ...
In a subset of 100 diffuse gliomas from the NOA-04 trial with long-term follow-up data available, the "integrated" diagnosis had a si …
FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke.
Brunkhorst R, Kanaan N, Koch A, Ferreirós N, Mirceska A, Zeiner P, Mittelbronn M, Derouiche A, Steinmetz H, Foerch C, Pfeilschifter J, Pfeilschifter W. Brunkhorst R, et al. Among authors: mittelbronn m. PLoS One. 2013 Jul 31;8(7):e70124. doi: 10.1371/journal.pone.0070124. Print 2013. PLoS One. 2013. PMID: 23936150 Free PMC article.
We examined whether a relatively late initiation of a FTY720 treatment has a positive effect on long-term neurological outcome with a focus on reactive astrogliosis, synapses and neurotrophic factors. ...CONCLUSION: Besides its known neuroprotective effects in the acute ph …
We examined whether a relatively late initiation of a FTY720 treatment has a positive effect on long-term neurological outcome with a …
Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent manner.
Scholz A, Lang V, Henschler R, Czabanka M, Vajkoczy P, Chavakis E, Drynski J, Harter PN, Mittelbronn M, Dumont DJ, Plate KH, Reiss Y. Scholz A, et al. Among authors: mittelbronn m. Blood. 2011 Nov 3;118(18):5050-9. doi: 10.1182/blood-2011-03-343293. Epub 2011 Aug 25. Blood. 2011. PMID: 21868579 Free article.
To identify the underlying mechanism, we made use of a transgenic mouse model with inducible endothelial cell-specific expression of Ang-2. In this model, in the absence of inflammatory stimuli, long-term expression of Ang-2 led to a time-dependent accumulation of myeloid …
To identify the underlying mechanism, we made use of a transgenic mouse model with inducible endothelial cell-specific expression of Ang-2. …
Myogenesis in human denervated muscle biopsies.
Doppler K, Mittelbronn M, Bornemann A. Doppler K, et al. Among authors: mittelbronn m. Muscle Nerve. 2008 Jan;37(1):79-83. doi: 10.1002/mus.20902. Muscle Nerve. 2008. PMID: 17912750
Electron microscopic studies of long-term denervated rat muscles have identified very small, immature myofibers that are believed to arise from detached satellite cells that have fused to form new fibers within the interstitial space. ...
Electron microscopic studies of long-term denervated rat muscles have identified very small, immature myofibers that are believed to …
Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth.
Schittenhelm J, Mittelbronn M, Wolff M, Truebenbach J, Will BE, Meyermann R, Beschorner R. Schittenhelm J, et al. Among authors: mittelbronn m. Neuropathology. 2007 Aug;27(4):383-9. doi: 10.1111/j.1440-1789.2007.00780.x. Neuropathology. 2007. PMID: 17899694
After subtotal resection of a histopathologically confirmed DNT we observed unexpected tumor progression in long-term follow-up. Therefore, a second surgery was performed when the patient was 14 years of age. ...
After subtotal resection of a histopathologically confirmed DNT we observed unexpected tumor progression in long-term follow-up. Ther …
13 results