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Decompression illness: a comprehensive overview.
Mitchell SJ. Mitchell SJ. Diving Hyperb Med. 2024 Mar 31;54(1Suppl):1-53. doi: 10.28920/dhm54.1.suppl.1-53. Diving Hyperb Med. 2024. PMID: 38537300
Decompression illness is a collective term for two maladies (decompression sickness [DCS] and arterial gas embolism [AGE]) that may arise during or after surfacing from compressed gas diving. ...
Decompression illness is a collective term for two maladies (decompression sickness [DCS] and arterial gas embolism [AGE]) that may a …
Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21.
Agius T, Emsley R, Lyon A, MacArthur MR, Kiesworo K, Faivre A, Stavart L, Lambelet M, Legouis D, de Seigneux S, Golshayan D, Lazeyras F, Yeh H, Markmann JF, Uygun K, Ocampo A, Mitchell SJ, Allagnat F, Déglise S, Longchamp A. Agius T, et al. Among authors: mitchell sj. Nat Commun. 2024 Feb 5;15(1):1073. doi: 10.1038/s41467-024-44866-3. Nat Commun. 2024. PMID: 38316771 Free PMC article.
Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks (carbohydrate loading) prior to surgery, part of a multimodal perioperative care pathway designed to enhance surgical recovery. ...
Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks (carbohydrate loading) prior to surgery, …
Short-term Pre-operative Methionine Restriction Induces Browning of Perivascular Adipose Tissue and Improves Vein Graft Remodeling in Mice.
Kip P, Sluiter TJ, MacArthur MR, Tao M, Jung J, Mitchell SJ, Kooijman S, Kruit N, Gorham J, Seidman JG, Quax PHA, Aikawa M, Ozaki CK, Mitchell JR, de Vries MR. Kip P, et al. Among authors: mitchell sj. bioRxiv [Preprint]. 2023 Nov 4:2023.11.02.565269. doi: 10.1101/2023.11.02.565269. bioRxiv. 2023. PMID: 37961405 Free PMC article. Preprint.
Short-term preoperative methionine restriction (MetR) shows promise as a translatable strategy to modulate the body's response to surgical injury. ...This study shows for the first time that the detrimental effects of dysfunctional PVAT on vascular remodeling can be revers …
Short-term preoperative methionine restriction (MetR) shows promise as a translatable strategy to modulate the body's response to sur …
Long-term fasting: Multi-system adaptations in humans (GENESIS) study-A single-arm interventional trial.
Grundler F, Viallon M, Mesnage R, Ruscica M, von Schacky C, Madeo F, Hofer SJ, Mitchell SJ, Croisille P, Wilhelmi de Toledo F. Grundler F, et al. Among authors: mitchell sj. Front Nutr. 2022 Nov 17;9:951000. doi: 10.3389/fnut.2022.951000. eCollection 2022. Front Nutr. 2022. PMID: 36466423 Free PMC article.
Therefore, this study will apply state-of-the-art techniques to investigate the effects of long-term fasting (LF) and food reintroduction in humans by a multi-systemic approach focusing on changes in body composition, organ and tissue volume, lipid transport and storage, s …
Therefore, this study will apply state-of-the-art techniques to investigate the effects of long-term fasting (LF) and food reintroduc …
Short-Term Ketogenic Diet Induces a Molecular Response That Is Distinct From Dietary Protein Restriction.
Kalafut KC, Mitchell SJ, MacArthur MR, Mitchell JR. Kalafut KC, et al. Among authors: mitchell sj. Front Nutr. 2022 Mar 30;9:839341. doi: 10.3389/fnut.2022.839341. eCollection 2022. Front Nutr. 2022. PMID: 35433789 Free PMC article.
There is increasing interest in utilizing short-term dietary interventions in the contexts of cancer, surgical stress and metabolic disease. These short-term diets may be more feasible than extended interventions and may be designed to complement existing therapies. …
There is increasing interest in utilizing short-term dietary interventions in the contexts of cancer, surgical stress and metabolic d …
Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation.
Hine C, Treviño-Villarreal JH, Mejia P, Longchamp A, Brace LE, Harputlugil E, Mitchell SJ, Yang J, Guan Y, Maciejewski JP, Jha BK, Mitchell JR. Hine C, et al. Among authors: mitchell sj. Nutrients. 2022 Apr 6;14(7):1529. doi: 10.3390/nu14071529. Nutrients. 2022. PMID: 35406143 Free PMC article.
The exogenous addition of H(2)S inhibited Ten eleven translocation 2 (TET2) activity in vitro, thus providing a potential mechanism of action. Short-term CR or fasting therefore offers BM radioprotection and promotes regrowth in part via altered sulfur amino acid metabolis …
The exogenous addition of H(2)S inhibited Ten eleven translocation 2 (TET2) activity in vitro, thus providing a potential mechanism of actio …
A retrospective audit of postoperative days alive and out of hospital, including before and after implementation of the WHO surgical safety checklist.
Moore MR, Mitchell SJ, Weller JM, Cumin D, Cheeseman JF, Devcich DA, Hannam JA, Merry AF; CheckWHO group. Moore MR, et al. Among authors: mitchell sj. Anaesthesia. 2022 Feb;77(2):185-195. doi: 10.1111/anae.15554. Epub 2021 Aug 1. Anaesthesia. 2022. PMID: 34333761 Free article.
The cohort changes in these outcomes were indistinguishable from longer-term trends in mortality and days alive and out of hospital observed during 9 years, as determined by Bayesian changepoint analysis. ...
The cohort changes in these outcomes were indistinguishable from longer-term trends in mortality and days alive and out of hospital o …
Periprocedural Hydrogen Sulfide Therapy Improves Vascular Remodeling and Attenuates Vein Graft Disease.
Kip P, Tao M, Trocha KM, MacArthur MR, Peters HAB, Mitchell SJ, Mann CG, Sluiter TJ, Jung J, Patterson S, Quax PHA, de Vries MR, Mitchell JR, Keith Ozaki C. Kip P, et al. Among authors: mitchell sj. J Am Heart Assoc. 2020 Nov 17;9(22):e016391. doi: 10.1161/JAHA.120.016391. Epub 2020 Nov 4. J Am Heart Assoc. 2020. PMID: 33146045 Free PMC article.
One promising approach to improve outcomes is endogenous upregulation of the gaseous transmitter-molecule hydrogen sulfide, via short-term dietary restriction. However, strict patient compliance stands as a potential translational barrier in the vascular surgery patient po …
One promising approach to improve outcomes is endogenous upregulation of the gaseous transmitter-molecule hydrogen sulfide, via short-ter
Disulfiram Treatment Normalizes Body Weight in Obese Mice.
Bernier M, Mitchell SJ, Wahl D, Diaz A, Singh A, Seo W, Wang M, Ali A, Kaiser T, Price NL, Aon MA, Kim EY, Petr MA, Cai H, Warren A, Di Germanio C, Di Francesco A, Fishbein K, Guiterrez V, Harney D, Koay YC, Mach J, Enamorado IN, Pulpitel T, Wang Y, Zhang J, Zhang L, Spencer RG, Becker KG, Egan JM, Lakatta EG, O'Sullivan J, Larance M, LeCouteur DG, Cogger VC, Gao B, Fernandez-Hernando C, Cuervo AM, de Cabo R. Bernier M, et al. Among authors: mitchell sj. Cell Metab. 2020 Aug 4;32(2):203-214.e4. doi: 10.1016/j.cmet.2020.04.019. Epub 2020 May 14. Cell Metab. 2020. PMID: 32413333 Free PMC article.
Reductions in feeding efficiency and increases in energy expenditure were associated with body weight regulation in response to long-term disulfiram treatment. Loss of fat tissue and an increase in liver fenestrations were also observed in rats on disulfiram. ...
Reductions in feeding efficiency and increases in energy expenditure were associated with body weight regulation in response to long-term
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