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Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models.
Guimaraes LC, Costa PAC, Scalzo Júnior SRA, Ferreira HAS, Braga ACS, de Oliveira LC, Figueiredo MM, Shepherd S, Hamilton A, Queiroz-Junior CM, da Silva WN, da Silva NJA, Rodrigues Alves MT, Santos AK, de Faria KKS, Marim FM, Fukumasu H, Birbrair A, Teixeira-Carvalho A, de Aguiar RS, Mitchell MJ, Teixeira MM, Vasconcelos Costa V, Frezard F, Guimaraes PPG. Guimaraes LC, et al. Among authors: mitchell mj. Nat Commun. 2024 Jan 18;15(1):590. doi: 10.1038/s41467-024-44830-1. Nat Commun. 2024. PMID: 38238326 Free PMC article.
A safe and effective vaccine with long-term protection against SARS-CoV-2 variants of concern (VOCs) is a global health priority. ...
A safe and effective vaccine with long-term protection against SARS-CoV-2 variants of concern (VOCs) is a global health priority. ...
In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism.
Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, Weissman D, Mitchell MJ. Billingsley MM, et al. Among authors: mitchell mj. Small. 2024 Mar;20(11):e2304378. doi: 10.1002/smll.202304378. Epub 2023 Dec 10. Small. 2024. PMID: 38072809
However, these therapies rely on ex vivo viral transduction to induce permanent CAR expression in T cells, which contributes to high production costs and long-term side effects. Thus, this work aims to develop an in vivo CAR T cell engineering platform to streamline produc …
However, these therapies rely on ex vivo viral transduction to induce permanent CAR expression in T cells, which contributes to high product …
Oral formulation of Wnt inhibitor complex reduces inflammation and fibrosis in intraperitoneal implants in vivo.
de Castro Santos AL, da Silva NJA, Viana CTR, Dos Santos LCC, da Silva GHC, Scalzo Júnior SRA, Costa PAC, da Silva WN, de Jesus ICG, Birbrair A, de Magalhães MTQ, Frézard F, Guatimosim S, Haley RM, Mitchell MJ, Andrade SP, Campos PP, Guimaraes PPG. de Castro Santos AL, et al. Among authors: mitchell mj. Drug Deliv Transl Res. 2023 May;13(5):1420-1435. doi: 10.1007/s13346-023-01303-0. Epub 2023 Feb 7. Drug Deliv Transl Res. 2023. PMID: 36749480
The use of implantable biomaterials to replace physiological and anatomical functions has been widely investigated in the clinic. However, the selection of biomaterials is crucial for long-term function, and the implantation of certain biomaterials can cause inflammatory a …
The use of implantable biomaterials to replace physiological and anatomical functions has been widely investigated in the clinic. However, t …
Platelet-Mimicking Nanosponges for Functional Reversal of Antiplatelet Agents.
Xu J, Yan N, Wang C, Gao C, Han X, Yang C, Xu J, Wang K, Mitchell MJ, Zhang Y, Nie G. Xu J, et al. Among authors: mitchell mj. Circ Res. 2023 Feb 3;132(3):339-354. doi: 10.1161/CIRCRESAHA.122.321034. Epub 2023 Jan 10. Circ Res. 2023. PMID: 36625267 Free PMC article.
BACKGROUND: During long-term antiplatelet agents (APAs) administration, patients with thrombotic diseases take a fairly high risk of life-threatening bleeding, especially when in need of urgent surgery. ...
BACKGROUND: During long-term antiplatelet agents (APAs) administration, patients with thrombotic diseases take a fairly high risk of …
A mixed-methods analysis examining child and family needs following early brain injury.
Miley AE, Fisher AP, Moscato EL, Culp A, Mitchell MJ, Hindert KC, Makoroff KL, Rhine TD, Wade SL. Miley AE, et al. Among authors: mitchell mj. Disabil Rehabil. 2022 Jul;44(14):3566-3576. doi: 10.1080/09638288.2020.1870757. Epub 2021 Jan 18. Disabil Rehabil. 2022. PMID: 33459078
Caregivers noted unmet needs post-injury, such as child behavior management and caregiver stress and coping.Conclusion: Early TBI can have a long-term impact on the child, caregivers, and family system. Addressing the needs of the whole family system in intervention and re …
Caregivers noted unmet needs post-injury, such as child behavior management and caregiver stress and coping.Conclusion: Early TBI can have a …
Consequence of altered nitrogen cycles in the coupled human and ecological system under changing climate: The need for long-term and site-based research.
Shibata H, Branquinho C, McDowell WH, Mitchell MJ, Monteith DT, Tang J, Arvola L, Cruz C, Cusack DF, Halada L, Kopáček J, Máguas C, Sajidu S, Schubert H, Tokuchi N, Záhora J. Shibata H, et al. Among authors: mitchell mj. Ambio. 2015 Apr;44(3):178-93. doi: 10.1007/s13280-014-0545-4. Epub 2014 Jul 19. Ambio. 2015. PMID: 25037589 Free PMC article. Review.
Current understanding of the biogeochemical processes that govern the N cycle in coupled human-ecological systems around the globe is drawn largely from the long-term ecological monitoring and experimental studies. Here, we review spatial and temporal patterns and trends i …
Current understanding of the biogeochemical processes that govern the N cycle in coupled human-ecological systems around the globe is drawn …
Mercury proxies and mercury dynamics in a forested watershed of the US Northeast.
Vidon P, Carleton W, Mitchell MJ. Vidon P, et al. Among authors: mitchell mj. Environ Monit Assess. 2014 Nov;186(11):7475-88. doi: 10.1007/s10661-014-3941-0. Epub 2014 Jul 14. Environ Monit Assess. 2014. PMID: 25017991
From a management perspective, land cover modifications (lake, reservoir, and wetland) are likely to play more important roles at regulating Hg, MeHg, and DOC exports at the watershed scale than long-term changes in the climate of this region....
From a management perspective, land cover modifications (lake, reservoir, and wetland) are likely to play more important roles at regulating …
Watershed sulfur biogeochemistry: shift from atmospheric deposition dominance to climatic regulation.
Mitchell MJ, Likens GE. Mitchell MJ, et al. Environ Sci Technol. 2011 Jun 15;45(12):5267-71. doi: 10.1021/es200844n. Epub 2011 May 19. Environ Sci Technol. 2011. PMID: 21595471
These changes in S biogeochemistry have important implications with respect to the mobilization of toxic (Al(n+), H+) and nutrient (Ca2+, Mg2+, K+) cations and the acidification of watersheds. We used the continuous long-term record for watersheds 1, 3, 5, and 6 (37-44 yea …
These changes in S biogeochemistry have important implications with respect to the mobilization of toxic (Al(n+), H+) and nutrient (Ca2+, Mg …
The epidemiology of calcaneal fractures.
Mitchell MJ, McKinley JC, Robinson CM. Mitchell MJ, et al. Foot (Edinb). 2009 Dec;19(4):197-200. doi: 10.1016/j.foot.2009.05.001. Foot (Edinb). 2009. PMID: 20307476
BACKGROUND: Calcaneal fractures are rare, but debilitating injuries, which occur frequently in younger individuals. The economic impact of the residual long-term disability that may occur after these injuries is therefore disproportionate to their incidence. ...
BACKGROUND: Calcaneal fractures are rare, but debilitating injuries, which occur frequently in younger individuals. The economic impact of t …
Influences of a calcium gradient on soil inorganic nitrogen in the Adirondack Mountains, New York.
Page BD, Mitchell MJ. Page BD, et al. Among authors: mitchell mj. Ecol Appl. 2008 Oct;18(7):1604-14. doi: 10.1890/07-0150.1. Ecol Appl. 2008. PMID: 18839757
Studies of the long-term impacts of acidic deposition in Europe and North America have prompted growing interest in understanding the dynamics linking the nitrogen (N) and calcium (Ca) cycles in forested watersheds. ...
Studies of the long-term impacts of acidic deposition in Europe and North America have prompted growing interest in understanding the …
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