Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

7 results

Filters applied: . Clear all
Page 1
Cloning of non-human primates: the road "less traveled by".
Sparman ML, Tachibana M, Mitalipov SM. Sparman ML, et al. Among authors: mitalipov sm. Int J Dev Biol. 2010;54(11-12):1671-8. doi: 10.1387/ijdb.103196ms. Int J Dev Biol. 2010. PMID: 21404187 Free PMC article. Review.
Early studies on cloning of non-human primates by nuclear transfer utilized embryonic blastomeres from preimplantation embryos which resulted in the reproducible birth of live offspring. Soon after, the focus shifted to employing somatic cells as a source of donor nuclei ( …
Early studies on cloning of non-human primates by nuclear transfer utilized embryonic blastomeres from preimplantation embryos which resulte …
[Pluripotent stem cells: maintenance of genetic and epigenetic stability and prospects of cell technologies].
Gordeeva OF, Mitalipov ShM. Gordeeva OF, et al. Ontogenez. 2008 Nov-Dec;39(6):405-19. Ontogenez. 2008. PMID: 19137706 Review. Russian.
Ten years of intense studies on the stability of different human and monkey embryonic stem cells demonstrated that, irrespective of their origin, long-term in vitro cultures lead to the accumulation of chromosomal and gene mutations as well as epigenetic changes that can c …
Ten years of intense studies on the stability of different human and monkey embryonic stem cells demonstrated that, irrespective of their or …
Gene targeting in adult rhesus macaque fibroblasts.
Meehan DT, Zink MA, Mahlen M, Nelson M, Sanger WG, Mitalipov SM, Wolf DP, Ouellette MM, Norgren RB Jr. Meehan DT, et al. Among authors: mitalipov sm. BMC Biotechnol. 2008 Mar 26;8:31. doi: 10.1186/1472-6750-8-31. BMC Biotechnol. 2008. PMID: 18366794 Free PMC article.
RESULTS: A primary culture of adult male fibroblasts was transfected with hTERT to overcome senescence and allow long term in vitro manipulations. Successful gene targeting of the HPRT locus in rhesus macaques was achieved by electroporating S-phase synchronized cells with …
RESULTS: A primary culture of adult male fibroblasts was transfected with hTERT to overcome senescence and allow long term in vitro m …
Genomic imprinting in primate embryos and embryonic stem cells.
Mitalipov SM. Mitalipov SM. Reprod Fertil Dev. 2006;18(8):817-21. doi: 10.1071/rd06112. Reprod Fertil Dev. 2006. PMID: 17147929 Review.
Embryonic stem (ES) cells hold promise for cell and tissue replacement approaches to treating human diseases. However, long-term in vitro culture and manipulations of ES cells may adversely affect their epigenetic integrity including imprinting. ...
Embryonic stem (ES) cells hold promise for cell and tissue replacement approaches to treating human diseases. However, long-term in v …
Monozygotic twinning in rhesus monkeys by manipulation of in vitro-derived embryos.
Mitalipov SM, Yeoman RR, Kuo HC, Wolf DP. Mitalipov SM, et al. Biol Reprod. 2002 May;66(5):1449-55. doi: 10.1095/biolreprod66.5.1449. Biol Reprod. 2002. PMID: 11967209
Embryo transfers of identical sets led to a 33% clinical pregnancy rate, with two twin pregnancies initiated. Neither pregnancy resulted in term birth of monozygotic twins, but our results are sufficiently encouraging to justify a large-scale twinning trial in the r …
Embryo transfers of identical sets led to a 33% clinical pregnancy rate, with two twin pregnancies initiated. Neither pregnancy resulted in …
Rhesus monkey embryos produced by nuclear transfer from embryonic blastomeres or somatic cells.
Mitalipov SM, Yeoman RR, Nusser KD, Wolf DP. Mitalipov SM, et al. Biol Reprod. 2002 May;66(5):1367-73. doi: 10.1095/biolreprod66.5.1367. Biol Reprod. 2002. PMID: 11967199
Production of genetically identical nonhuman primates would reduce the number of animals required for biomedical research and dramatically impact studies pertaining to immune system function, such as development of the human-immunodeficiency-virus vaccine. Our long-term go …
Production of genetically identical nonhuman primates would reduce the number of animals required for biomedical research and dramatically i …
Mammalian cloning: possibilities and threats.
Mitalipov SM, Wolf DP. Mitalipov SM, et al. Ann Med. 2000 Oct;32(7):462-8. doi: 10.3109/07853890009002021. Ann Med. 2000. PMID: 11087166
Factors that contribute to the successful reprogramming of the transferred nucleus and the normal term development of the newly reconstructed embryo include the cell cycle stage of both the donor nucleus and recipient cytoplast, the timing of fusion and cytoplast activatio …
Factors that contribute to the successful reprogramming of the transferred nucleus and the normal term development of the newly recon …