Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Iguchi Y, Katsuno M, Niwa J, Takagi S, Ishigaki S, Ikenaka K, Kawai K, Watanabe H, Yamanaka K, Takahashi R, Misawa H, Sasaki S, Tanaka F, Sobue G.
Iguchi Y, et al. Among authors: misawa h.
Brain. 2013 May;136(Pt 5):1371-82. doi: 10.1093/brain/awt029. Epub 2013 Feb 28.
Brain. 2013.
PMID: 23449777
These findings suggest that transactive response DNA-binding protein 43 plays an essential role in the long term maintenance of motor neurons and that loss-of-function of this protein seems to contribute to the pathogenesis of amyotrophic lateral sclerosis....
These findings suggest that transactive response DNA-binding protein 43 plays an essential role in the long term maintenance of motor …