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Public engagement with genomics.
Middleton A, Adams A, Aidid H, Atutornu J, Boraschi D, Borra J, Bircan T, Burch C, Costa A, Dickinson A, Enticknap A, Galloway C, Gale F, Garlick E, Haydon E, Henriques S, Mitchell M, Milne R, Monaghan J, Morley KI, Muella Santos M, Olivares Boldu L, Olumogba F, Orviss K, Parry V, Patch C, Robarts L, Shingles S, Smidt C, Tomlin B, Parkinson S. Middleton A, et al. Among authors: milne r. Wellcome Open Res. 2023 Sep 18;8:310. doi: 10.12688/wellcomeopenres.19473.2. eCollection 2023. Wellcome Open Res. 2023. PMID: 37928209 Free PMC article. Review.
Most public audiences do not feel actively connected to science, are oftenunsure of the relevance to their lives and rarely talk to their family and friends about; we term this dis-connection a 'disengaged public audience'. We use a narrative review to explore: (i) UK atti …
Most public audiences do not feel actively connected to science, are oftenunsure of the relevance to their lives and rarely talk to their fa …
The establishment of plants following long-distance dispersal.
Wu ZY, Milne RI, Liu J, Nathan R, Corlett RT, Li DZ. Wu ZY, et al. Among authors: milne ri. Trends Ecol Evol. 2023 Mar;38(3):289-300. doi: 10.1016/j.tree.2022.11.003. Epub 2022 Nov 28. Trends Ecol Evol. 2023. PMID: 36456382 Review.
By addressing current knowledge gaps, we aim to further our understanding of how LDD affects plant distributions, and the long-term consequences of LDD events....
By addressing current knowledge gaps, we aim to further our understanding of how LDD affects plant distributions, and the long-term c …
Low-frequency pre-treatment HIV drug resistance: effects on 2-year outcome of first-line efavirenz-based antiretroviral therapy.
Milne RS, Beck IA, Levine M, So I, Andersen N, Deng W, Panpradist N, Kingoo J, Kiptinness C, Yatich N, Kiarie JN, Sakr SR, Chung MH, Frenkel LM. Milne RS, et al. AIDS. 2022 Nov 15;36(14):1949-1958. doi: 10.1097/QAD.0000000000003361. Epub 2022 Aug 18. AIDS. 2022. PMID: 36305180 Free PMC article.
OBJECTIVES: Assess the impact of pre-treatment high-frequency and low-frequency drug-resistant HIV variants on long-term outcomes of first-line efavirenz-based antiretroviral therapy (ART). ...
OBJECTIVES: Assess the impact of pre-treatment high-frequency and low-frequency drug-resistant HIV variants on long-term outcomes of …
A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women.
Wang X, Chen H, Middha Kapoor P, Su YR, Bolla MK, Dennis J, Dunning AM, Lush M, Wang Q, Michailidou K, Pharoah PDP, Hopper JL, Southey MC, Koutros S, Beane Freeman LE, Stone J, Rennert G, Shibli R, Murphy RA, Aronson K, Guénel P, Truong T, Teras LR, Hodge JM, Canzian F, Kaaks R, Brenner H, Arndt V, Hoppe R, Lo WY, Behrens S, Mannermaa A, Kosma VM, Jung A, Becher H, Giles GG, Haiman CA, Maskarinec G, Scott C, Winham S, Simard J, Goldberg MS, Zheng W, Long J, Troester MA, Love MI, Peng C, Tamimi R, Eliassen H, García-Closas M, Figueroa J, Ahearn T, Yang R, Evans DG, Howell A, Hall P, Czene K, Wolk A, Sandler DP, Taylor JA, Swerdlow AJ, Orr N, Lacey JV, Wang S, Olsson H, Easton DF, Milne RL, Hsu L, Kraft P, Chang-Claude J, Lindström S. Wang X, et al. Among authors: milne rl. Cancer Res Commun. 2022 Apr;2(4):211-219. doi: 10.1158/2767-9764.CRC-21-0119. Epub 2022 Apr 8. Cancer Res Commun. 2022. PMID: 36303815 Free PMC article.
The strongest interaction observed was between the predicted expression of the C13orf45 gene and age at first full-term pregnancy (P(GXE)=4.4410(-6)). CONCLUSION: In this transcriptome-informed genome-wide gene-environment interaction study of breast cancer, we found no st …
The strongest interaction observed was between the predicted expression of the C13orf45 gene and age at first full-term pregnancy (P( …
Assessment of minority frequency pretreatment HIV drug-resistant variants in pregnant women and associations with virologic non-suppression at term.
Boyce CL, Beck IA, Styrchak SM, Hardy SR, Wallner JJ, Milne RS, Morrison RL, Shapiro DE, João EC, Mirochnick MH, Frenkel LM. Boyce CL, et al. Among authors: milne rs. PLoS One. 2022 Sep 27;17(9):e0275254. doi: 10.1371/journal.pone.0275254. eCollection 2022. PLoS One. 2022. PMID: 36166463 Free PMC article. Clinical Trial.
Among cases with viral rebound (n = 3/22), none had PDR detected. Virologic non-suppression at term was associated with higher plasma HIV RNA at study entry (p<0.0001), a shorter duration of ART prior to delivery (p<0.0001), and randomization to efavirenz- (versus ra …
Among cases with viral rebound (n = 3/22), none had PDR detected. Virologic non-suppression at term was associated with higher plasma …
Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?
Yu C, Hodge AM, Wong EM, Joo JE, Makalic E, Schmidt DF, Buchanan DD, Severi G, Hopper JL, English DR, Giles GG, Milne RL, Southey MC, Dugué PA. Yu C, et al. Among authors: milne rl. Epigenetics. 2022 Dec;17(12):1838-1847. doi: 10.1080/15592294.2022.2088038. Epub 2022 Jun 20. Epigenetics. 2022. PMID: 35726372 Free PMC article.
There was weak evidence that the association of smoking with GrimAge was attenuated in participants genetically predisposed to smoking (interaction term: -0.022, standard error [SE] = 0.012, P = 0.058) and that the association of alcohol consumption with PhenoAge was atten …
There was weak evidence that the association of smoking with GrimAge was attenuated in participants genetically predisposed to smoking (inte …
Hospital Cost Savings for Sequential COPD Patients Receiving Domiciliary Nasal High Flow Therapy.
Milne RJ, Hockey HU, Garrett J. Milne RJ, et al. Int J Chron Obstruct Pulmon Dis. 2022 Jun 3;17:1311-1322. doi: 10.2147/COPD.S350267. eCollection 2022. Int J Chron Obstruct Pulmon Dis. 2022. PMID: 35686212 Free PMC article. Clinical Trial.
PURPOSE: To estimate the 5-year budget impact to Aotearoa New Zealand (NZ) hospitals of domiciliary nasal high flow (NHF) therapy to patients with chronic obstructive pulmonary disease (COPD) who require long term oxygen therapy. METHODS: Hospital admission counts along wi …
PURPOSE: To estimate the 5-year budget impact to Aotearoa New Zealand (NZ) hospitals of domiciliary nasal high flow (NHF) therapy to patient …
Oral Contraceptive Use in BRCA1 and BRCA2 Mutation Carriers: Absolute Cancer Risks and Benefits.
Schrijver LH, Mooij TM, Pijpe A, Sonke GS, Mourits MJE, Andrieu N, Antoniou AC, Easton DF, Engel C, Goldgar D, John EM, Kast K, Milne RL, Olsson H, Phillips KA, Terry MB, Hopper JL, van Leeuwen FE, Rookus MA. Schrijver LH, et al. Among authors: milne rl. J Natl Cancer Inst. 2022 Apr 11;114(4):540-552. doi: 10.1093/jnci/djac004. J Natl Cancer Inst. 2022. PMID: 35048954 Free PMC article.
RESULTS: COCP use initially increased breast cancer risk and decreased ovarian and endometrial cancer risk long term. For 10 000 BRCA1 mutation carriers, 10 years of COCP use from age 20 to 30 years resulted in 66 additional COCP-associated cancer cases by the age of 35 ye …
RESULTS: COCP use initially increased breast cancer risk and decreased ovarian and endometrial cancer risk long term. For 10 000 BRCA …
Assessing and disclosing test results for 'mild cognitive impairment': the perspective of old age psychiatrists in Scotland.
Saunders S, Ritchie CW, Russ TC, Muniz-Terrera G, Milne R. Saunders S, et al. Among authors: milne r. BMC Geriatr. 2022 Jan 12;22(1):50. doi: 10.1186/s12877-021-02693-x. BMC Geriatr. 2022. PMID: 35022025 Free PMC article.
RESULTS: Initial results show that most clinicians interviewed (Total N = 19) considered MCI to have significant limitations as a diagnostic term. Nevertheless, most clinicians reported using the term MCI (n = 15/19). ...Some clinicians consider the condition as a s …
RESULTS: Initial results show that most clinicians interviewed (Total N = 19) considered MCI to have significant limitations as a diagnostic …
Prospective Evaluation over 15 Years of Six Breast Cancer Risk Models.
Li SX, Milne RL, Nguyen-Dumont T, English DR, Giles GG, Southey MC, Antoniou AC, Lee A, Winship I, Hopper JL, Terry MB, MacInnis RJ. Li SX, et al. Among authors: milne rl. Cancers (Basel). 2021 Oct 16;13(20):5194. doi: 10.3390/cancers13205194. Cancers (Basel). 2021. PMID: 34680343 Free PMC article.
Prospective validation of risk models is needed to assess their clinical utility, particularly over the longer term. We evaluated the performance of six commonly used breast cancer risk models (IBIS, BOADICEA, BRCAPRO, BRCAPRO-BCRAT, BCRAT, and iCARE-lit). 15-year risk sco …
Prospective validation of risk models is needed to assess their clinical utility, particularly over the longer term. We evaluated the …
59 results