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Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification.
Aakre KM, Apple FS, Mills NL, Meex SJR, Collinson PO; International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB). Aakre KM, et al. Among authors: mills nl. Clin Chem. 2024 Mar 2;70(3):497-505. doi: 10.1093/clinchem/hvad185. Clin Chem. 2024. PMID: 38102065 Review.
BACKGROUND: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for long-term risk prediction of cardiovascular disease. Accelerated diagnostic pathways prevent unnecessary hospital admission, but requir …
BACKGROUND: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for lo …
Implementation of a high sensitivity cardiac troponin I assay and risk of myocardial infarction or death at five years: observational analysis of a stepped wedge, cluster randomised controlled trial.
Lee KK, Doudesis D, Ferry AV, Chapman AR, Kimenai DM, Fujisawa T, Bularga A, Lowry MTH, Taggart C, Schulberg S, Wereski R, Tuck C, Strachan FE, Newby DE, Anand A, Shah ASV, Mills NL; High-STEACS Investigators. Lee KK, et al. Among authors: mills nl. BMJ. 2023 Nov 27;383:e075009. doi: 10.1136/bmj-2023-075009. BMJ. 2023. PMID: 38011922 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the impact of implementing a high sensitivity assay for cardiac troponin I on long term outcomes in patients with suspected acute coronary syndrome. ...
OBJECTIVE: To evaluate the impact of implementing a high sensitivity assay for cardiac troponin I on long term outcomes in patients w …
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.
C-MORE/PHOSP-COVID Collaborative Group. C-MORE/PHOSP-COVID Collaborative Group. Lancet Respir Med. 2023 Nov;11(11):1003-1019. doi: 10.1016/S2213-2600(23)00262-X. Epub 2023 Sep 22. Lancet Respir Med. 2023. PMID: 37748493 Free PMC article.
INTERPRETATION: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeu …
INTERPRETATION: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings e …
Single Troponin Measurement to Rule Out Myocardial Infarction: JACC Review Topic of the Week.
Jaffe AS, Body R, Mills NL, Aakre KM, Collinson PO, Saenger A, Hammarsten O, Wereski R, Omland T, Sandoval Y, Ordonez-Llanos J, Apple FS; IFCC Committee on Cardiac Bio-Markers. Jaffe AS, et al. Among authors: mills nl. J Am Coll Cardiol. 2023 Jul 4;82(1):60-69. doi: 10.1016/j.jacc.2023.04.040. J Am Coll Cardiol. 2023. PMID: 37380305 Review.
The term "single-sample rule-out" refers to the ability of very low concentrations of high-sensitivity cardiac troponin (hs-cTn) on presentation to exclude acute myocardial infarction with high clinical sensitivity and negative predictive value. ...
The term "single-sample rule-out" refers to the ability of very low concentrations of high-sensitivity cardiac troponin (hs-cTn) on p …
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study.
Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE, Chalder T, Chalmers JD, Chaudhuri N, Docherty AB, Donaldson G, Edwardson CL, Elneima O, Greening NJ, Hanley NA, Harris VC, Harrison EM, Ho LP, Houchen-Wolloff L, Howard LS, Jolley CJ, Jones MG, Leavy OC, Lewis KE, Lone NI, Marks M, McAuley HJC, McNarry MA, Patel BV, Piper-Hanley K, Poinasamy K, Raman B, Richardson M, Rivera-Ortega P, Rowland-Jones SL, Rowlands AV, Saunders RM, Scott JT, Sereno M, Shah AM, Shikotra A, Singapuri A, Stanel SC, Thorpe M, Wootton DG, Yates T, Gisli Jenkins R, Singh SJ, Man WD, Brightling CE, Wain LV, Porter JC, Thompson AAR, Horsley A, Molyneaux PL, Evans RA, Jones SE, Rutter MK, Blaikley JF; PHOSP-COVID Study Collaborative Group. Jackson C, et al. Lancet Respir Med. 2023 Aug;11(8):673-684. doi: 10.1016/S2213-2600(23)00124-8. Epub 2023 Apr 15. Lancet Respir Med. 2023. PMID: 37072018 Free PMC article.
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.
McAuley HJC, Evans RA, Bolton CE, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Greenhaff PL, Gupta A, Harris VC, Harrison EM, Ho LP, Horsley A, Houchen-Wolloff L, Jolley CJ, Leavy OC, Lone NI, Man WD, Marks M, Parekh D, Poinasamy K, Quint JK, Raman B, Richardson M, Saunders RM, Sereno M, Shikotra A, Singapuri A, Singh SJ, Steiner M, Tan AL, Wain LV, Welch C, Whitney J, Witham MD, Lord J, Greening NJ; PHOSP-COVID Study Collaborative Group. McAuley HJC, et al. EClinicalMedicine. 2023 Mar 11;57:101896. doi: 10.1016/j.eclinm.2023.101896. eCollection 2023 Mar. EClinicalMedicine. 2023. PMID: 36936404 Free PMC article.
BACKGROUND: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. ...
BACKGROUND: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes i …
Performance status: A key factor in predicting mortality in the first wave of COVID-19 in South-East Scotland.
Mutch CP, Ross DA, Bularga A, Nicola Rose Cave R, Chase-Topping ME, Anand A, Mills NL, Koch O, Mackintosh CL, Perry MR; DataLoch COVID-19 Collaborative. Mutch CP, et al. Among authors: mills nl. J R Coll Physicians Edinb. 2022 Sep;52(3):204-212. doi: 10.1177/14782715221120137. Epub 2022 Aug 22. J R Coll Physicians Edinb. 2022. PMID: 36369813 Free PMC article.
BACKGROUND: COVID-19 mortality risk factors have been established in large cohort studies; long-term mortality outcomes are less documented. METHODS: We performed multivariable logistic regression to identify factors associated with in-patient mortality and intensive care …
BACKGROUND: COVID-19 mortality risk factors have been established in large cohort studies; long-term mortality outcomes are less docu …
Efficacy of telemedicine for the management of cardiovascular disease: a systematic review and meta-analysis.
Kuan PX, Chan WK, Fern Ying DK, Rahman MAA, Peariasamy KM, Lai NM, Mills NL, Anand A. Kuan PX, et al. Among authors: mills nl. Lancet Digit Health. 2022 Sep;4(9):e676-e691. doi: 10.1016/S2589-7500(22)00124-8. Lancet Digit Health. 2022. PMID: 36028290 Free PMC article.
Combined remote monitoring and consultation for patients with heart failure was associated with a reduced risk of cardiovascular-related mortality (risk ratio [RR] 0.83 [95% CI 0.70 to 0.99]; p=0.036) and hospitalisation for a cardiovascular cause (0.71 [0.58 to 0.87]; p=0.0002), …
Combined remote monitoring and consultation for patients with heart failure was associated with a reduced risk of cardiovascular-related mor …
Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis.
Farrah TE, Melville V, Czopek A, Fok H, Bruce L, Mills NL, Bailey MA, Webb DJ, Dear JW, Dhaun N. Farrah TE, et al. Among authors: mills nl. Kidney Int. 2022 Nov;102(5):1115-1126. doi: 10.1016/j.kint.2022.07.026. Epub 2022 Aug 20. Kidney Int. 2022. PMID: 35998848 Free article. Clinical Trial.
Therefore, in a series of double-blind, randomized case-control forearm plethysmography and crossover systemic interventional studies, we examined arterial stiffness and endothelial function in patients with AAV in long-term disease remission and in matched healthy volunte …
Therefore, in a series of double-blind, randomized case-control forearm plethysmography and crossover systemic interventional studies, we ex …
Infective Endocarditis Hospitalizations and Outcomes in Patients With End-Stage Kidney Disease: A Nationwide Data-Linkage Study.
Gallacher PJ, McAllister DA, Mills NL, Cruden NL, Shah ASV, Dhaun N. Gallacher PJ, et al. Among authors: mills nl. J Am Heart Assoc. 2021 Oct 5;10(19):e022002. doi: 10.1161/JAHA.121.022002. Epub 2021 Sep 28. J Am Heart Assoc. 2021. PMID: 34581192 Free PMC article.
Background We investigated the clinical features, microbiology, and short- and long-term outcomes of incident infective endocarditis (IE) hospitalizations in patients with end-stage kidney disease (ESKD) requiring dialysis or with a kidney transplant over 25 years in Scotl …
Background We investigated the clinical features, microbiology, and short- and long-term outcomes of incident infective endocarditis …
41 results