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Reducing Hospitalizations and Multidrug-Resistant Organisms via Regional Decolonization in Hospitals and Nursing Homes.
Gussin GM, McKinnell JA, Singh RD, Miller LG, Kleinman K, Saavedra R, Tjoa T, Gohil SK, Catuna TD, Heim LT, Chang J, Estevez M, He J, O'Donnell K, Zahn M, Lee E, Berman C, Nguyen J, Agrawal S, Ashbaugh I, Nedelcu C, Robinson PA, Tam S, Park S, Evans KD, Shimabukuro JA, Lee BY, Fonda E, Jernigan JA, Slayton RB, Stone ND, Janssen L, Weinstein RA, Hayden MK, Lin MY, Peterson EM, Bittencourt CE, Huang SS; CDC Safety and Healthcare Epidemiology Prevention Research Development (SHEPheRD) Program. Gussin GM, et al. Among authors: miller lg. JAMA. 2024 May 14;331(18):1544-1557. doi: 10.1001/jama.2024.2759. JAMA. 2024. PMID: 38557703
EXPOSURES: Chlorhexidine bathing and nasal iodophor antisepsis for residents in long-term care and hospitalized patients in contact precautions (CP). ...CONCLUSIONS AND RELEVANCE: A regional collaborative involving universal decolonization in long-term care faciliti …
EXPOSURES: Chlorhexidine bathing and nasal iodophor antisepsis for residents in long-term care and hospitalized patients in contact p …
Decolonization in Nursing Homes to Prevent Infection and Hospitalization.
Miller LG, McKinnell JA, Singh RD, Gussin GM, Kleinman K, Saavedra R, Mendez J, Catuna TD, Felix J, Chang J, Heim L, Franco R, Tjoa T, Stone ND, Steinberg K, Beecham N, Montgomery J, Walters D, Park S, Tam S, Gohil SK, Robinson PA, Estevez M, Lewis B, Shimabukuro JA, Tchakalian G, Miner A, Torres C, Evans KD, Bittencourt CE, He J, Lee E, Nedelcu C, Lu J, Agrawal S, Sturdevant SG, Peterson E, Huang SS. Miller LG, et al. N Engl J Med. 2023 Nov 9;389(19):1766-1777. doi: 10.1056/NEJMoa2215254. Epub 2023 Oct 10. N Engl J Med. 2023. PMID: 37815935 Clinical Trial.
Single-step genome engineering in the bee gut symbiont Snodgrassella alvi.
Lariviere PJ, Ashraf AHMZ, Leonard SP, Miller LG, Moran NA, Barrick JE. Lariviere PJ, et al. Among authors: miller lg. bioRxiv [Preprint]. 2023 Sep 20:2023.09.19.558440. doi: 10.1101/2023.09.19.558440. bioRxiv. 2023. PMID: 37786689 Free PMC article. Preprint.
To solve this problem, we developed a one-step procedure that uses electroporation and homologous recombination, which we term SnODIFY (Snodgrassella-specific One-step gene Deletion or Insertion to alter FunctionalitY). ...
To solve this problem, we developed a one-step procedure that uses electroporation and homologous recombination, which we term SnODIF …
Safety and tolerability of tedizolid as oral treatment for bone and joint infections.
Miller LG, Flores EA, Launer B, Lee P, Kalkat P, Derrah K, Agrawal S, Schwartz M, Steele G, Kim T, Kuvhenguhwa MS. Miller LG, et al. Microbiol Spectr. 2023 Sep 26;11(5):e0128223. doi: 10.1128/spectrum.01282-23. Online ahead of print. Microbiol Spectr. 2023. PMID: 37750695 Free PMC article.
However, there are limited safe oral options for many Gram-positive pathogens. In animal studies and short-term human use, tedizolid lacks the hematologic and neurologic toxicity of the other available oxazolidinone, linezolid. ...
However, there are limited safe oral options for many Gram-positive pathogens. In animal studies and short-term human use, tedizolid …
Clinical Impact of Ceftriaxone Resistance in Escherichia coli Bloodstream Infections: A Multicenter Prospective Cohort Study.
Tamma PD, Komarow L, Ge L, Garcia-Diaz J, Herc ES, Doi Y, Arias CA, Albin O, Saade E, Miller LG, Jacob JT, Satlin MJ, Krsak M, Huskins WC, Dhar S, Shelburne SA, Hill C, Baum KR, Bhojani M, Greenwood-Quaintance KE, Schmidt-Malan SM, Patel R, Evans SR, Chambers HF, Fowler VG Jr, van Duin D; Antibacterial Resistance Leadership Group. Tamma PD, et al. Among authors: miller lg. Open Forum Infect Dis. 2022 Oct 27;9(11):ofac572. doi: 10.1093/ofid/ofac572. eCollection 2022 Nov. Open Forum Infect Dis. 2022. PMID: 36381622 Free PMC article.
Secondary outcomes included unadjusted and adjusted differences in the proportion of 30-day mortality between CRO-R and CRO-S BSIs (-5.3% [95% CI, -10.3% to -.4%] and -1.8 [95% CI, -6.7% to 3.2%], respectively), postculture median length of stay (8 days [IQR, 5-13 days] vs 6 days …
Secondary outcomes included unadjusted and adjusted differences in the proportion of 30-day mortality between CRO-R and CRO-S BSIs (-5.3% [9 …
Modeling Interventions to Reduce the Spread of Multidrug-Resistant Organisms Between Health Care Facilities in a Region.
Bartsch SM, Wong KF, Mueller LE, Gussin GM, McKinnell JA, Tjoa T, Wedlock PT, He J, Chang J, Gohil SK, Miller LG, Huang SS, Lee BY. Bartsch SM, et al. Among authors: miller lg. JAMA Netw Open. 2021 Aug 2;4(8):e2119212. doi: 10.1001/jamanetworkopen.2021.19212. JAMA Netw Open. 2021. PMID: 34347060 Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: An agent-based model of health care facilities was developed in 2016 to simulate the spread of methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Enterobacteriaceae (CRE) for 10 years starting in 2010 and to simulate the …
DESIGN, SETTING, AND PARTICIPANTS: An agent-based model of health care facilities was developed in 2016 to simulate the spread of methicilli …
High Prevalence of Multidrug-Resistant Organism Colonization in 28 Nursing Homes: An "Iceberg Effect".
McKinnell JA, Miller LG, Singh RD, Gussin G, Kleinman K, Mendez J, Laurner B, Catuna TD, Heim L, Saavedra R, Felix J, Torres C, Chang J, Estevez M, Mendez J, Tchakalian G, Bloomfield L, Ceja S, Franco R, Miner A, Hurtado A, Hean R, Varasteh A, Robinson PA, Park S, Tam S, Tjoa T, He J, Agrawal S, Yamaguchi S, Custodio H, Nguyen J, Bittencourt CE, Evans KD, Mor V, McConeghy K, Weinstein RA, Hayden MK, Stone ND, Steinberg K, Beecham N, Montgomery J, DeAnn W, Peterson EM, Huang SS. McKinnell JA, et al. Among authors: miller lg. J Am Med Dir Assoc. 2020 Dec;21(12):1937-1943.e2. doi: 10.1016/j.jamda.2020.04.007. Epub 2020 Jun 16. J Am Med Dir Assoc. 2020. PMID: 32553489 Free PMC article.
The SHIELD Orange County Project: Multidrug-resistant Organism Prevalence in 21 Nursing Homes and Long-term Acute Care Facilities in Southern California.
McKinnell JA, Singh RD, Miller LG, Kleinman K, Gussin G, He J, Saavedra R, Dutciuc TD, Estevez M, Chang J, Heim L, Yamaguchi S, Custodio H, Gohil SK, Park S, Tam S, Robinson PA, Tjoa T, Nguyen J, Evans KD, Bittencourt CE, Lee BY, Mueller LE, Bartsch SM, Jernigan JA, Slayton RB, Stone ND, Zahn M, Mor V, McConeghy K, Baier RR, Janssen L, O'Donnell K, Weinstein RA, Hayden MK, Coady MH, Bhattarai M, Peterson EM, Huang SS. McKinnell JA, et al. Among authors: miller lg. Clin Infect Dis. 2019 Oct 15;69(9):1566-1573. doi: 10.1093/cid/ciz119. Clin Infect Dis. 2019. PMID: 30753383 Free PMC article.
BACKGROUND: Multidrug-resistant organisms (MDROs) spread between hospitals, nursing homes (NHs), and long-term acute care facilities (LTACs) via patient transfers. The Shared Healthcare Intervention to Eliminate Life-threatening Dissemination of MDROs in Orange County is a …
BACKGROUND: Multidrug-resistant organisms (MDROs) spread between hospitals, nursing homes (NHs), and long-term acute care facilities …
Acetylenotrophy: a hidden but ubiquitous microbial metabolism?
Akob DM, Sutton JM, Fierst JL, Haase KB, Baesman S, Luther GW 3rd, Miller LG, Oremland RS. Akob DM, et al. Among authors: miller lg. FEMS Microbiol Ecol. 2018 Aug 1;94(8):fiy103. doi: 10.1093/femsec/fiy103. FEMS Microbiol Ecol. 2018. PMID: 29933435 Free PMC article. Review.
Here, we review what is known about acetylene degrading organisms and introduce the term 'acetylenotrophs' to refer to the microorganisms that carry out this metabolic pathway. ...
Here, we review what is known about acetylene degrading organisms and introduce the term 'acetylenotrophs' to refer to the microorgan …
24 results