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Predominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials.
Core JQ, Pistilli M, Hua P, Daniel E, Grunwald JE, Toth CA, Jaffe GJ, Martin DF, Maguire MG, Ying GS; Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group. Core JQ, et al. Ophthalmol Retina. 2022 Sep;6(9):771-785. doi: 10.1016/j.oret.2022.03.024. Epub 2022 Apr 9. Ophthalmol Retina. 2022. PMID: 35405352 Free PMC article. Clinical Trial.
Predominantly persistent intraretinal fluid through year 1 was associated with worse long-term VA, but the relationship disappeared after adjustment for baseline predictors of VA. Predominantly persistent intraretinal fluid through year 2 was independently associated with …
Predominantly persistent intraretinal fluid through year 1 was associated with worse long-term VA, but the relationship disappeared a …
Subjective and objective outcomes in randomized clinical trials: definitions differed in methods publications and were often absent from trial reports.
Moustgaard H, Bello S, Miller FG, Hróbjartsson A. Moustgaard H, et al. Among authors: miller fg. J Clin Epidemiol. 2014 Dec;67(12):1327-34. doi: 10.1016/j.jclinepi.2014.06.020. Epub 2014 Sep 26. J Clin Epidemiol. 2014. PMID: 25263546 Review.
Three distinct definitions were provided for subjective outcome: (1) dependent on assessor judgment, (2) patient-reported outcome, or (3) private phenomena (ie, phenomena only assessable by the patient). Of the 200 clinical trial reports, 12 used the term "subjective" and/ …
Three distinct definitions were provided for subjective outcome: (1) dependent on assessor judgment, (2) patient-reported outcome, or (3) pr …
Macular morphology and visual acuity in the comparison of age-related macular degeneration treatments trials.
Jaffe GJ, Martin DF, Toth CA, Daniel E, Maguire MG, Ying GS, Grunwald JE, Huang J; Comparison of Age-related Macular Degeneration Treatments Trials Research Group. Jaffe GJ, et al. Ophthalmology. 2013 Sep;120(9):1860-70. doi: 10.1016/j.ophtha.2013.01.073. Epub 2013 May 1. Ophthalmology. 2013. PMID: 23642377 Free PMC article. Clinical Trial.
Monthly ranibizumab dosing yielded more eyes with no fluid and an abnormally thin retina, although the long-term significance is unknown. These results have important treatment implications in eyes undergoing anti-VEGF therapy for neovascular AMD. ...
Monthly ranibizumab dosing yielded more eyes with no fluid and an abnormally thin retina, although the long-term significance is unkn …
Evaluating the therapeutic misconception.
Miller FG, Joffe S. Miller FG, et al. Kennedy Inst Ethics J. 2006 Dec;16(4):353-66. doi: 10.1353/ken.2006.0025. Kennedy Inst Ethics J. 2006. PMID: 17847601
The "therapeutic misconception", described by Paul Appelbaum and colleagues more than 20 years ago, refers to the tendency of participants in clinical trials to confuse the design and conduct of research with personalized medical care. Although the "therapeutic misconception" has …
The "therapeutic misconception", described by Paul Appelbaum and colleagues more than 20 years ago, refers to the tendency of participants i …
Placebo-controlled trials in psychiatric research: an ethical perspective.
Miller FG. Miller FG. Biol Psychiatry. 2000 Apr 15;47(8):707-16. doi: 10.1016/s0006-3223(00)00833-7. Biol Psychiatry. 2000. PMID: 10773177
Four standards governing the ethical use of placebos in psychiatric clinical trials are explicated: 1) placebo-controlled trials should have scientific and clinical merit; 2) risks should be minimized and justified by the anticipated benefits of generating clinically relevant sci …
Four standards governing the ethical use of placebos in psychiatric clinical trials are explicated: 1) placebo-controlled trials should have …