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Ferret Lung Transplantation Models Differential Lymphoid Aggregate Morphology Between Restrictive and Obstructive Forms of Chronic Lung Allograft Dysfunction.
Lynch TJ, Ahlers BA, Swatek AM, Ievlev V, Pai AC, Brooks L, Tang Y, Evans IA, Meyerholz DK, Engelhardt JF, Parekh KR. Lynch TJ, et al. Among authors: meyerholz dk. Transplantation. 2022 Oct 1;106(10):1974-1989. doi: 10.1097/TP.0000000000004148. Epub 2022 Apr 15. Transplantation. 2022. PMID: 35442232 Free PMC article.
BACKGROUND: Long-term survival after lung transplantation remains limited by chronic lung allograft dysfunction (CLAD). ...
BACKGROUND: Long-term survival after lung transplantation remains limited by chronic lung allograft dysfunction (CLAD). ...
Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia.
Krishnamurthy S, Wohlford-Lenane C, Kandimalla S, Sartre G, Meyerholz DK, Théberge V, Hallée S, Duperré AM, Del'Guidice T, Lepetit-Stoffaes JP, Barbeau X, Guay D, McCray PB Jr. Krishnamurthy S, et al. Among authors: meyerholz dk. Nat Commun. 2019 Oct 28;10(1):4906. doi: 10.1038/s41467-019-12922-y. Nat Commun. 2019. PMID: 31659165 Free PMC article.
Instillation of shuttle peptides combined with SpCas9 or AsCas12a RNP achieves editing of loxP sites in airway epithelia of ROSA(mT/mG) mice. We observe no evidence of short-term toxicity with a widespread distribution restricted to the respiratory tract. ...
Instillation of shuttle peptides combined with SpCas9 or AsCas12a RNP achieves editing of loxP sites in airway epithelia of ROSA(mT/mG) mice …
Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.
Cooney AL, Singh BK, Loza LM, Thornell IM, Hippee CE, Powers LS, Ostedgaard LS, Meyerholz DK, Wohlford-Lenane C, Stoltz DA, B McCray P Jr, Sinn PL. Cooney AL, et al. Among authors: meyerholz dk. Nucleic Acids Res. 2018 Oct 12;46(18):9591-9600. doi: 10.1093/nar/gky773. Nucleic Acids Res. 2018. PMID: 30165523 Free PMC article.
Ferret lung transplant: an orthotopic model of obliterative bronchiolitis.
Sui H, Olivier AK, Klesney-Tait JA, Brooks L, Tyler SR, Sun X, Skopec A, Kline J, Sanchez PG, Meyerholz DK, Zavazava N, Iannettoni M, Engelhardt JF, Parekh KR. Sui H, et al. Among authors: meyerholz dk. Am J Transplant. 2013 Feb;13(2):467-73. doi: 10.1111/j.1600-6143.2012.04337.x. Epub 2012 Dec 3. Am J Transplant. 2013. PMID: 23205765 Free PMC article.
Cycling of IS, to induce repeated episodes of controlled rejection, promoted classic histologic hallmarks of OB including fibrosis-associated occlusion of the bronchiolar airways in all allografts of long-term survivors. In conclusion, we have developed an orthotopic lung …
Cycling of IS, to induce repeated episodes of controlled rejection, promoted classic histologic hallmarks of OB including fibrosis-associate …
Exposure to ethanol during the last trimester of pregnancy alters the maturation and immunity of the fetal lung.
Lazic T, Sow FB, Van Geelen A, Meyerholz DK, Gallup JM, Ackermann MR. Lazic T, et al. Among authors: meyerholz dk. Alcohol. 2011 Nov;45(7):673-80. doi: 10.1016/j.alcohol.2010.11.001. Epub 2010 Dec 15. Alcohol. 2011. PMID: 21163613 Free PMC article.
Preterm animals exposed to ethanol had significantly reduced VEGF-A mRNA (P=.066) and protein levels, HIF-1alpha (P=.055), HIF-2alpha (P=.019), VEGFR-1 (P=.088), and VEGFR-2 (P=.067) mRNA levels but no changes in HIF-3alpha mRNA. No significant changes occurred in full-term …
Preterm animals exposed to ethanol had significantly reduced VEGF-A mRNA (P=.066) and protein levels, HIF-1alpha (P=.055), HIF-2alpha (P=.01 …
Effects of nicotine on pulmonary surfactant proteins A and D in ovine lung epithelia.
Lazic T, Matic M, Gallup JM, Van Geelen A, Meyerholz DK, Grubor B, Imerman PM, de-Macedo MM, Ackermann MR. Lazic T, et al. Among authors: meyerholz dk. Pediatr Pulmonol. 2010 Mar;45(3):255-62. doi: 10.1002/ppul.21153. Pediatr Pulmonol. 2010. PMID: 20131324 Free PMC article.
Pregnant ewes were assigned to four groups; a nicotine-exposed full-term and pre-term group, and control full-term and pre-term group. ...Exposure to nicotine significantly decreased SP-A gene expression (P = 0.01) and SP-A protein level in pre-term …
Pregnant ewes were assigned to four groups; a nicotine-exposed full-term and pre-term group, and control full-term and …
Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.
McGill J, Meyerholz DK, Edsen-Moore M, Young B, Coleman RA, Schlueter AJ, Waldschmidt TJ, Cook RT, Legge KL. McGill J, et al. Among authors: meyerholz dk. J Immunol. 2009 Jun 15;182(12):7803-8. doi: 10.4049/jimmunol.0803881. J Immunol. 2009. PMID: 19494304 Free PMC article.
However, little is known about fetal alcohol exposure (FAE) effects on adult infections. Therefore, to determine the long-term effects of FAE on disease susceptibility and the adult immune system, we infected FAE adult mice with influenza virus. ...Together, our results su …
However, little is known about fetal alcohol exposure (FAE) effects on adult infections. Therefore, to determine the long-term effect …
Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2.
Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. Netland J, et al. Among authors: meyerholz dk. J Virol. 2008 Aug;82(15):7264-75. doi: 10.1128/JVI.00737-08. Epub 2008 May 21. J Virol. 2008. PMID: 18495771 Free PMC article.
While the lungs are the major site of infection, the brain is also infected in some patients. Brain infection may result in long-term neurological sequelae, but little is known about the pathogenesis of SARS-CoV in this organ. ...
While the lungs are the major site of infection, the brain is also infected in some patients. Brain infection may result in long-term …
Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia.
Lazic T, Wyatt TA, Matic M, Meyerholz DK, Grubor B, Gallup JM, Kersting KW, Imerman PM, Almeida-De-Macedo M, Ackermann MR. Lazic T, et al. Among authors: meyerholz dk. Alcohol. 2007 Aug;41(5):347-55. doi: 10.1016/j.alcohol.2007.07.006. Alcohol. 2007. PMID: 17889311 Free PMC article.
In addition to neurodevelopmental effects, alcohol consumption at high levels during pregnancy is associated with immunomodulation and premature birth. Premature birth, in turn, is associated with increased susceptibility to various infectious agents such as respira …
In addition to neurodevelopmental effects, alcohol consumption at high levels during pregnancy is associated with immunomodulation and prema …
Differential expression of ovine innate immune genes by preterm and neonatal lung epithelia infected with respiratory syncytial virus.
Kawashima K, Meyerholz DK, Gallup JM, Grubor B, Lazic T, Lehmkuhl HD, Ackermann MR. Kawashima K, et al. Among authors: meyerholz dk. Viral Immunol. 2006 Summer;19(2):316-23. doi: 10.1089/vim.2006.19.316. Viral Immunol. 2006. PMID: 16817774 Free PMC article.
Control lambs had increased expression of innate immune molecules in full term (term) compared to preterm epithelia with statistical significance in SBD1, SP-D, and TLR4 mRNA. Infected cells (bRSV+ fluorescent cells) had consistently higher mRNA levels of SP-A (pret …
Control lambs had increased expression of innate immune molecules in full term (term) compared to preterm epithelia with stati …
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