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32 results

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Page 1
Long-term measles antibody profiles following different vaccine schedules in China, a longitudinal study.
Wang Q, Wang W, Winter AK, Zhan Z, Ajelli M, Trentini F, Wang L, Li F, Yang J, Xiang X, Liao Q, Zhou J, Guo J, Yan X, Liu N, Metcalf CJE, Grenfell BT, Yu H. Wang Q, et al. Among authors: metcalf cje. Nat Commun. 2023 Mar 29;14(1):1746. doi: 10.1038/s41467-023-37407-x. Nat Commun. 2023. PMID: 36990986 Free PMC article.
Characterizing the long-term kinetics of maternally derived and vaccine-induced measles immunity is critical for informing measles immunization strategies moving forward. ...
Characterizing the long-term kinetics of maternally derived and vaccine-induced measles immunity is critical for informing measles im …
Opportunities and challenges in modeling emerging infectious diseases.
Metcalf CJE, Lessler J. Metcalf CJE, et al. Science. 2017 Jul 14;357(6347):149-152. doi: 10.1126/science.aam8335. Science. 2017. PMID: 28706037 Free PMC article. Review.
The term "pathogen emergence" encompasses everything from previously unidentified viruses entering the human population to established pathogens invading new populations and the evolution of drug resistance. ...
The term "pathogen emergence" encompasses everything from previously unidentified viruses entering the human population to establishe …
Long-term benefits of nonpharmaceutical interventions for endemic infections are shaped by respiratory pathogen dynamics.
Baker RE, Saad-Roy CM, Park SW, Farrar J, Metcalf CJE, Grenfell BT. Baker RE, et al. Among authors: metcalf cje. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2208895119. doi: 10.1073/pnas.2208895119. Epub 2022 Nov 29. Proc Natl Acad Sci U S A. 2022. PMID: 36445971 Free PMC article.
A key public health question is whether NPIs could continue to be implemented long term to reduce the ongoing burden from endemic pathogens. Here, we use epidemiological models to explore the impact of long-term NPIs on the dynamics of endemic infections. ...Our res …
A key public health question is whether NPIs could continue to be implemented long term to reduce the ongoing burden from endemic pat …
Tensor decomposition for infectious disease incidence data.
Korevaar H, Metcalf CJ, Grenfell BT. Korevaar H, et al. Among authors: metcalf cj. Methods Ecol Evol. 2020 Dec;11(12):1690-1700. doi: 10.1111/2041-210X.13480. Epub 2020 Sep 22. Methods Ecol Evol. 2020. PMID: 33381294 Free PMC article.
Seasonality in infectious disease transmission can result from climatic forces such as temperature and humidity; variation in contact rates as a result of migration or school calendar; or temporary surges in birth rates. Seasonal drivers of acute immunizing infections can …
Seasonality in infectious disease transmission can result from climatic forces such as temperature and humidity; variation in contact rates …
Challenges in modeling the emergence of novel pathogens.
Glennon EE, Bruijning M, Lessler J, Miller IF, Rice BL, Thompson RN, Wells K, Metcalf CJE. Glennon EE, et al. Among authors: metcalf cje. Epidemics. 2021 Dec;37:100516. doi: 10.1016/j.epidem.2021.100516. Epub 2021 Oct 25. Epidemics. 2021. PMID: 34775298 Free article.
Here, we describe core directions for expansion of the existing tools and knowledge base, including: using mathematical models to identify critical directions and paths for strengthening data collection to detect and respond to outbreaks of novel pathogens; expanding basic theory …
Here, we describe core directions for expansion of the existing tools and knowledge base, including: using mathematical models to identify c …
Medium-term scenarios of COVID-19 as a function of immune uncertainties and chronic disease.
Saad-Roy CM, Morris SE, Baker RE, Farrar J, Graham AL, Levin SA, Wagner CE, Metcalf CJE, Grenfell BT. Saad-Roy CM, et al. Among authors: metcalf cje. J R Soc Interface. 2023 Aug;20(205):20230247. doi: 10.1098/rsif.2023.0247. Epub 2023 Aug 30. J R Soc Interface. 2023. PMID: 37643641
As the SARS-CoV-2 trajectory continues, the longer-term immuno-epidemiology of COVID-19, the dynamics of Long COVID, and the impact of escape variants are important outstanding questions. ...If immunity (to infection or Long COVID) accumulates rapidly with the valency of e …
As the SARS-CoV-2 trajectory continues, the longer-term immuno-epidemiology of COVID-19, the dynamics of Long COVID, and the impact o …
Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes.
Saad-Roy CM, Morris SE, Metcalf CJE, Mina MJ, Baker RE, Farrar J, Holmes EC, Pybus OG, Graham AL, Levin SA, Grenfell BT, Wagner CE. Saad-Roy CM, et al. Among authors: metcalf cje. Science. 2021 Apr 23;372(6540):363-370. doi: 10.1126/science.abg8663. Epub 2021 Mar 9. Science. 2021. PMID: 33688062 Free PMC article.
Building on an existing immuno-epidemiological model, we find that in the short term, focusing on one dose generally decreases infections, but that longer-term outcomes depend on this relative immune robustness. ...
Building on an existing immuno-epidemiological model, we find that in the short term, focusing on one dose generally decreases infect …
Epidemiological and evolutionary considerations of SARS-CoV-2 vaccine dosing regimes.
Saad-Roy CM, Morris SE, Metcalf CJE, Mina MJ, Baker RE, Farrar J, Holmes EC, Pybus OG, Graham AL, Levin SA, Grenfell BT, Wagner CE. Saad-Roy CM, et al. Among authors: metcalf cje. medRxiv [Preprint]. 2021 Feb 3:2021.02.01.21250944. doi: 10.1101/2021.02.01.21250944. medRxiv. 2021. PMID: 33564785 Free PMC article. Updated. Preprint.
Building on an existing immuno-epidemiological model, we find that in the short-term, focusing on one dose generally decreases infections, but longer-term outcomes depend on this relative immune robustness. ...
Building on an existing immuno-epidemiological model, we find that in the short-term, focusing on one dose generally decreases infect …
Comparing and linking machine learning and semi-mechanistic models for the predictability of endemic measles dynamics.
Lau MSY, Becker A, Madden W, Waller LA, Metcalf CJE, Grenfell BT. Lau MSY, et al. Among authors: metcalf cje. PLoS Comput Biol. 2022 Sep 8;18(9):e1010251. doi: 10.1371/journal.pcbi.1010251. eCollection 2022 Sep. PLoS Comput Biol. 2022. PMID: 36074763 Free PMC article.
First, our results indicate that the proposed LASSO model can efficiently use data from multiple major cities and achieve similar short-to-medium term forecasting performance to semi-mechanistic models for E&W epidemics. ...LASSO may also outperform TSIR for predicting …
First, our results indicate that the proposed LASSO model can efficiently use data from multiple major cities and achieve similar short-to-m …
Long term intrinsic cycling in human life course antibody responses to influenza A(H3N2): an observational and modeling study.
Yang B, García-Carreras B, Lessler J, Read JM, Zhu H, Metcalf CJE, Hay JA, Kwok KO, Shen R, Jiang CQ, Guan Y, Riley S, Cummings DA. Yang B, et al. Among authors: metcalf cje. Elife. 2022 Dec 2;11:e81457. doi: 10.7554/eLife.81457. Elife. 2022. PMID: 36458815 Free PMC article.
To investigate possible biological mechanisms, we simulated individual antibody profiles encompassing known feedbacks and interactions due to generally recognized immunological mechanisms. RESULTS: We demonstrated a long-term periodicity (about 24 years) in individual anti …
To investigate possible biological mechanisms, we simulated individual antibody profiles encompassing known feedbacks and interactions due t …
32 results