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Metal-ion-mediated allosteric triggering of yeast pyruvate kinase. 2. A multidimensional thermodynamic linked-function analysis.
Mesecar AD, Nowak T. Mesecar AD, et al. Biochemistry. 1997 Jun 3;36(22):6803-13. doi: 10.1021/bi962870s. Biochemistry. 1997. PMID: 9184163
These values indicate that positive, heterotropic interactions exist between each of these ligand pairs. The three ligand coupling free energy term, deltaG(Mn-PEP-FDP), indicates that simultaneous binding of Mn2+, PEP, and FDP is considerably favored over the sum of their …
These values indicate that positive, heterotropic interactions exist between each of these ligand pairs. The three ligand coupling free ener …