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Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives.
Yang C, Merlin D. Yang C, et al. Among authors: merlin d. Int J Nanomedicine. 2019 Nov 13;14:8875-8889. doi: 10.2147/IJN.S210315. eCollection 2019. Int J Nanomedicine. 2019. PMID: 32009785 Free PMC article. Review.
Some of these medications were effective in alleviating the early-stage inflammatory symptoms, but their long-term efficacies were compromised by the accumulation of toxicities. ...
Some of these medications were effective in alleviating the early-stage inflammatory symptoms, but their long-term efficacies were co …
Dietary Emulsifier-Induced Low-Grade Inflammation Promotes Colon Carcinogenesis.
Viennois E, Merlin D, Gewirtz AT, Chassaing B. Viennois E, et al. Among authors: merlin d. Cancer Res. 2017 Jan 1;77(1):27-40. doi: 10.1158/0008-5472.CAN-16-1359. Epub 2016 Nov 7. Cancer Res. 2017. PMID: 27821485 Free PMC article.
The increased risks conferred by inflammatory bowel disease (IBD) to the development of colorectal cancer gave rise to the term "colitis-associated cancer" and the concept that inflammation promotes colon tumorigenesis. ...
The increased risks conferred by inflammatory bowel disease (IBD) to the development of colorectal cancer gave rise to the term "coli …
Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression.
Mwangi SM, Peng S, Nezami BG, Thorn N, Farris AB 3rd, Jain S, Laroui H, Merlin D, Anania F, Srinivasan S. Mwangi SM, et al. Among authors: merlin d. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15;310(2):G103-16. doi: 10.1152/ajpgi.00196.2015. Epub 2015 Nov 12. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 26564715 Free PMC article.
They also had significantly reduced peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and CD36 gene expression and protein levels, and lower expression of mRNA coding for enzymes involved in de novo lipogenesis. GDNF-loaded nanoparticles were protective against short- …
They also had significantly reduced peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and CD36 gene expression and protein level …
Biomarkers of Inflammatory Bowel Disease: From Classical Laboratory Tools to Personalized Medicine.
Viennois E, Zhao Y, Merlin D. Viennois E, et al. Among authors: merlin d. Inflamm Bowel Dis. 2015 Oct;21(10):2467-74. doi: 10.1097/MIB.0000000000000444. Inflamm Bowel Dis. 2015. PMID: 25985250 Free PMC article. Review.
The current method of diagnostic remains a critical challenge for physicians in part due to their invasiveness and also for their limitations in term of diagnosis, prognosis, disease activity and severity assessment, and therapeutic outcomes. ...
The current method of diagnostic remains a critical challenge for physicians in part due to their invasiveness and also for their limitation …
Leptin transcriptionally enhances peptide transporter (hPepT1) expression and activity via the cAMP-response element-binding protein and Cdx2 transcription factors.
Nduati V, Yan Y, Dalmasso G, Driss A, Sitaraman S, Merlin D. Nduati V, et al. Among authors: merlin d. J Biol Chem. 2007 Jan 12;282(2):1359-73. doi: 10.1074/jbc.M604267200. Epub 2006 Sep 8. J Biol Chem. 2007. PMID: 16963449 Free article.
To begin elucidating inflammatory hPepT1 signaling, we herein investigated the long term leptin treatments, on PepT1 expression and activity in Caco2-BBE cells, and began to reveal the involved signaling pathways. ...
To begin elucidating inflammatory hPepT1 signaling, we herein investigated the long term leptin treatments, on PepT1 expression and a …
Interferon-gamma modulates cAMP-induced mucin exocytosis without affecting mucin gene expression in a human colonic goblet cell line.
Jarry A, Merlin D, Velcich A, Hopfer U, Augenlicht LH, Laboisse CL. Jarry A, et al. Among authors: merlin d. Eur J Pharmacol. 1994 Mar 15;267(1):95-103. doi: 10.1016/0922-4106(94)90229-1. Eur J Pharmacol. 1994. PMID: 7515824
The aim of the present study was (1) to investigate the regulatory effects of interferon-gamma on baseline and stimulated mucin secretion elicited by an increase in intracellular cAMP, either a short-term increase (induced by vasoactive intestinal peptide or by forskolin) …
The aim of the present study was (1) to investigate the regulatory effects of interferon-gamma on baseline and stimulated mucin secretion el …