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Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study.
Bosma KJ, Martin CM, Burns KEA, Mancebo Cortes J, Suárez Montero JC, Skrobik Y, Thorpe KE, Amaral ACK, Arabi Y, Basmaji J, Beduneau G, Beloncle F, Carteaux G, Charbonney E, Demoule A, Dres M, Fanelli V, Geagea A, Goligher E, Lellouche F, Maraffi T, Mercat A, Rodriguez PO, Shahin J, Sibley S, Spadaro S, Vaporidi K, Wilcox ME, Brochard L; Canadian Critical Care Trials Group and; REVA Network. Bosma KJ, et al. Among authors: mercat a. Trials. 2023 Mar 27;24(1):232. doi: 10.1186/s13063-023-07163-w. Trials. 2023. PMID: 36973743 Free PMC article.
The proportional assistance, called the gain, can be adjusted by the clinician to maintain the patient's respiratory effort or workload within a normal range. Short-term and physiological benefits of this mode compared to pressure support ventilation (PSV) include better p …
The proportional assistance, called the gain, can be adjusted by the clinician to maintain the patient's respiratory effort or workload with …
Response to Ventilator Adjustments for Predicting Acute Respiratory Distress Syndrome Mortality. Driving Pressure versus Oxygenation.
Yehya N, Hodgson CL, Amato MBP, Richard JC, Brochard LJ, Mercat A, Goligher EC. Yehya N, et al. Among authors: mercat a. Ann Am Thorac Soc. 2021 May;18(5):857-864. doi: 10.1513/AnnalsATS.202007-862OC. Ann Am Thorac Soc. 2021. PMID: 33112644 Free PMC article.
Rationale: Clinicians commonly use short-term physiologic markers to assess the benefit of ventilator adjustments. ...
Rationale: Clinicians commonly use short-term physiologic markers to assess the benefit of ventilator adjustments. ...
Acute respiratory distress syndrome.
Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS. Matthay MA, et al. Among authors: mercat a. Nat Rev Dis Primers. 2019 Mar 14;5(1):18. doi: 10.1038/s41572-019-0069-0. Nat Rev Dis Primers. 2019. PMID: 30872586 Free PMC article. Review.
Treatment focuses on lung-protective ventilation; no specific pharmacotherapies have been identified. Long-term outcomes of patients with ARDS are increasingly recognized as important research targets, as many patients survive ARDS only to have ongoing functional and/or ps …
Treatment focuses on lung-protective ventilation; no specific pharmacotherapies have been identified. Long-term outcomes of patients …
Six-Month Outcome of Immunocompromised Patients with Severe Acute Respiratory Distress Syndrome Rescued by Extracorporeal Membrane Oxygenation. An International Multicenter Retrospective Study.
Schmidt M, Schellongowski P, Patroniti N, Taccone FS, Reis Miranda D, Reuter J, Prodanovic H, Pierrot M, Dorget A, Park S, Balik M, Demoule A, Crippa IA, Mercat A, Wohlfarth P, Sonneville R, Combes A; IDEA Study Group collaborators are as follows. Schmidt M, et al. Among authors: mercat a. Am J Respir Crit Care Med. 2018 May 15;197(10):1297-1307. doi: 10.1164/rccm.201708-1761OC. Am J Respir Crit Care Med. 2018. PMID: 29298095 Free PMC article.
Rationale: Because encouraging rates for hospital and long-term survival of immunocompromised patients in ICUs have been described, these patients are more likely to receive invasive therapies, like extracorporeal membrane oxygenation (ECMO).Objectives: To report outcomes …
Rationale: Because encouraging rates for hospital and long-term survival of immunocompromised patients in ICUs have been described, t …
Respiratory support in patients with acute respiratory distress syndrome: an expert opinion.
Chiumello D, Brochard L, Marini JJ, Slutsky AS, Mancebo J, Ranieri VM, Thompson BT, Papazian L, Schultz MJ, Amato M, Gattinoni L, Mercat A, Pesenti A, Talmor D, Vincent JL. Chiumello D, et al. Among authors: mercat a. Crit Care. 2017 Sep 12;21(1):240. doi: 10.1186/s13054-017-1820-0. Crit Care. 2017. PMID: 28899408 Free PMC article. Review.
Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality rates of around 30-45% and considerable long-term morbidity. Respiratory support in these patients must be optimized to ensure adequ …
Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality …
Designing and conducting a cluster-randomized trial of ICU admission for the elderly patients: the ICE-CUB 2 study.
Boumendil A, Woimant M, Quenot JP, Rooryck FX, Makhlouf F, Yordanov Y, Delerme S, Takun K, Ray P, Kouka MC, Poly C, Garrouste-Orgeas M, Thomas C, Simon T, Azerad S, Leblanc G, Pateron D, Guidet B; ICE-CUB 2 study network. Boumendil A, et al. Ann Intensive Care. 2016 Dec;6(1):74. doi: 10.1186/s13613-016-0161-5. Epub 2016 Jul 29. Ann Intensive Care. 2016. PMID: 27473119 Free PMC article.
The ICE-CUB 2 trial will be the first cluster-randomized trial to assess the benefits of ICU admission for selected elderly patients on long-term mortality. Trial registration Clinical trials.gov identifier: NCT01508819....
The ICE-CUB 2 trial will be the first cluster-randomized trial to assess the benefits of ICU admission for selected elderly patients on long …
Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial.
Mimoz O, Lucet JC, Kerforne T, Pascal J, Souweine B, Goudet V, Mercat A, Bouadma L, Lasocki S, Alfandari S, Friggeri A, Wallet F, Allou N, Ruckly S, Balayn D, Lepape A, Timsit JF; CLEAN trial investigators. Mimoz O, et al. Among authors: mercat a. Lancet. 2015 Nov 21;386(10008):2069-2077. doi: 10.1016/S0140-6736(15)00244-5. Epub 2015 Sep 18. Lancet. 2015. PMID: 26388532 Clinical Trial.
Optimisation of skin antisepsis is essential to prevent short-term catheter-related infections. We hypothesised that chlorhexidine-alcohol would be more effective than povidone iodine-alcohol as a skin antiseptic to prevent intravascular-catheter-related infections. ...INT …
Optimisation of skin antisepsis is essential to prevent short-term catheter-related infections. We hypothesised that chlorhexidine-al …
[Comprehensive geriatric assessment in intensive care unit: a pilot study (pre-Seniorea)].
Raveau T, Annweiler C, Chudeau N, Gergaud S, Thiery S, Gautier J, Beauchet O, Mercat A, Lerolle N. Raveau T, et al. Among authors: mercat a. Geriatr Psychol Neuropsychiatr Vieil. 2013 Dec;11(4):389-95. doi: 10.1684/pnv.2013.0441. Geriatr Psychol Neuropsychiatr Vieil. 2013. PMID: 24333817 French.
BACKGROUND: long-term outcomes of elderly patients after an intensive care unit (ICU) stay are not fully elucidated. ...CONCLUSION: the follow-up of elderly inpatient admitted to ICU with repeated CGAs, including long-term evaluations in the place of life, was feasi …
BACKGROUND: long-term outcomes of elderly patients after an intensive care unit (ICU) stay are not fully elucidated. ...CONCLUSION: t …
Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDS.
Luyt CE, Combes A, Becquemin MH, Beigelman-Aubry C, Hatem S, Brun AL, Zraik N, Carrat F, Grenier PA, Richard JM, Mercat A, Brochard L, Brun-Buisson C, Chastre J; REVA Study Group. Luyt CE, et al. Among authors: mercat a. Chest. 2012 Sep;142(3):583-592. doi: 10.1378/chest.11-2196. Chest. 2012. PMID: 22948576
BACKGROUND: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. ...
BACKGROUND: No data on long-term outcomes of survivors of 2009 influenza A(H1N1) (A[H1N1])-associated ARDS are available. ...
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J; Dexmedetomidine for Long-Term Sedation Investigators. Jakob SM, et al. JAMA. 2012 Mar 21;307(11):1151-60. doi: 10.1001/jama.2012.304. JAMA. 2012. PMID: 22436955 Clinical Trial.
CONTEXT: Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. ...
CONTEXT: Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. ...
11 results