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Silibinin Suppresses the Hyperlipidemic Effects of the ALK-Tyrosine Kinase Inhibitor Lorlatinib in Hepatic Cells.
Verdura S, Encinar JA, Fernández-Arroyo S, Joven J, Cuyàs E, Bosch-Barrera J, Menendez JA. Verdura S, et al. Among authors: menendez ja. Int J Mol Sci. 2022 Sep 1;23(17):9986. doi: 10.3390/ijms23179986. Int J Mol Sci. 2022. PMID: 36077379 Free PMC article.
A semi-targeted ultrahigh pressure liquid chromatography accurate mass quadrupole time-of-flight mass spectrometry with electrospray ionization (UHPLC-ESI-QTOF-MS/MS)-based lipidomic approach revealed that short-term treatment of hepatic cells with lorlatinib promotes the …
A semi-targeted ultrahigh pressure liquid chromatography accurate mass quadrupole time-of-flight mass spectrometry with electrospray ionizat …
Priority-based transformations of stimulus representation in visual working memory.
Wan Q, Menendez JA, Postle BR. Wan Q, et al. Among authors: menendez ja. PLoS Comput Biol. 2022 Jun 2;18(6):e1009062. doi: 10.1371/journal.pcbi.1009062. eCollection 2022 Jun. PLoS Comput Biol. 2022. PMID: 35653404 Free PMC article.
To acquire independent evidence for such a priority-based representational transformation, and to explore underlying mechanisms, we trained recurrent neural networks (RNNs) with a long short-term memory (LSTM) architecture to perform a 2-back WM task. Visualization of LSTM …
To acquire independent evidence for such a priority-based representational transformation, and to explore underlying mechanisms, we trained …
Mitostemness.
Cuyàs E, Verdura S, Folguera-Blasco N, Bastidas-Velez C, Martin ÁG, Alarcón T, Menendez JA. Cuyàs E, et al. Among authors: menendez ja. Cell Cycle. 2018;17(8):918-926. doi: 10.1080/15384101.2018.1467679. Epub 2018 Jul 2. Cell Cycle. 2018. PMID: 29886796 Free PMC article. Review.
Mitochondria are increasingly recognized key drivers in the origin and development of CSC functional traits. We here propose the new term "mitostemness" to designate the mitochondria-dependent signaling functions that, evolutionary rooted in the bacterial origin of mitocho …
Mitochondria are increasingly recognized key drivers in the origin and development of CSC functional traits. We here propose the new term …
Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users.
Luciano-Mateo F, Hernández-Aguilera A, Cabre N, Camps J, Fernández-Arroyo S, Lopez-Miranda J, Menendez JA, Joven J. Luciano-Mateo F, et al. Among authors: menendez ja. Nutrients. 2017 Feb 10;9(2):121. doi: 10.3390/nu9020121. Nutrients. 2017. PMID: 28208582 Free PMC article. Review.
Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide clinical strategies to improve healthspan. New aspects of metformin activity provide a link to many of the overlapping factors, especially t …
Understanding the complexity of the relationship between dietary provision and metabolic consequences in the long term might provide …
Metabostemness: a new cancer hallmark.
Menendez JA, Alarcón T. Menendez JA, et al. Front Oncol. 2014 Sep 29;4:262. doi: 10.3389/fonc.2014.00262. eCollection 2014. Front Oncol. 2014. PMID: 25325014 Free PMC article. Review.
The acquisition of and departure from stemness in cancer tissues might not only be hardwired by genetic controllers, but also by the pivotal regulatory role of the cellular metabotype, which may act as a "starter dough" for cancer stemness traits. We have coined the term m …
The acquisition of and departure from stemness in cancer tissues might not only be hardwired by genetic controllers, but also by the pivotal …
Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites.
Menendez JA, Alarcón T, Joven J. Menendez JA, et al. Cell Cycle. 2014;13(5):699-709. doi: 10.4161/cc.28079. Epub 2014 Feb 3. Cell Cycle. 2014. PMID: 24526120 Free PMC article.
Oncometabolites are defined as small-molecule components (or enantiomers) of normal metabolism whose accumulation causes signaling dysregulation to establish a milieu that initiates carcinogenesis. In a similar manner, we propose the term "gerometabolites" to refer to smal …
Oncometabolites are defined as small-molecule components (or enantiomers) of normal metabolism whose accumulation causes signaling dysregula …
Ubiquitous transgenic overexpression of C-C chemokine ligand 2: a model to assess the combined effect of high energy intake and continuous low-grade inflammation.
Rodríguez-Gallego E, Riera-Borrull M, Hernández-Aguilera A, Mariné-Casadó R, Rull A, Beltrán-Debón R, Luciano-Mateo F, Menendez JA, Vazquez-Martin A, Sirvent JJ, Martín-Paredero V, Corbí AL, Sierra-Filardi E, Aragonès G, García-Heredia A, Camps J, Alonso-Villaverde C, Joven J. Rodríguez-Gallego E, et al. Among authors: menendez ja. Mediators Inflamm. 2013;2013:953841. doi: 10.1155/2013/953841. Epub 2013 Dec 15. Mediators Inflamm. 2013. PMID: 24453432 Free PMC article.
Here, we present preliminary data on a mouse model created by using targeted gene knock-in technology to integrate an additional copy of the CCl2 gene in the Gt(ROSA)26Sor locus of the mouse genome via homologous recombination in embryonic stem cells. Short-term dietary ma …
Here, we present preliminary data on a mouse model created by using targeted gene knock-in technology to integrate an additional copy of the …
Mammosphere formation in breast carcinoma cell lines depends upon expression of E-cadherin.
Manuel Iglesias J, Beloqui I, Garcia-Garcia F, Leis O, Vazquez-Martin A, Eguiara A, Cufi S, Pavon A, Menendez JA, Dopazo J, Martin AG. Manuel Iglesias J, et al. Among authors: menendez ja. PLoS One. 2013 Oct 4;8(10):e77281. doi: 10.1371/journal.pone.0077281. eCollection 2013. PLoS One. 2013. PMID: 24124614 Free PMC article.
Only MCF7, T47D, BT474, MDA-MB-436 and JIMT1 were successfully propagated as long-term mammosphere cultures, measured as the increase in the number of viable cells upon serial non-adherent passages. ...HCC1937 and HCC1569 cells formed typical mammospheres, although they co …
Only MCF7, T47D, BT474, MDA-MB-436 and JIMT1 were successfully propagated as long-term mammosphere cultures, measured as the increase …
Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus.
Vazquez-Martin A, Oliveras-Ferraros C, Cufí S, Menendez JA. Vazquez-Martin A, et al. Among authors: menendez ja. Cell Cycle. 2011 Apr 15;10(8):1295-302. doi: 10.4161/cc.10.8.15342. Epub 2011 Apr 15. Cell Cycle. 2011. PMID: 21474997
PLK1 and PP-AMPKalpha(Thr172) were found to display a major spatio-temporal overlap early at centrosomes, from prophase until anaphase, and late at the midbody, during telophase and cytokinesis. Moreover, short-term treatment with the thiophene derivative GW843682X, a sele …
PLK1 and PP-AMPKalpha(Thr172) were found to display a major spatio-temporal overlap early at centrosomes, from prophase until anaphase, and …
Evolution of the predictive markers amphiregulin and epiregulin mRNAs during long-term cetuximab treatment of KRAS wild-type tumor cells.
Oliveras-Ferraros C, Massaguer Vall-Llovera A, Carrion Salip D, Vazquez-Martin A, Cufí S, Queralt B, Martin-Castillo B, Brunet J, de Llorens R, Menendez JA. Oliveras-Ferraros C, et al. Among authors: menendez ja. Invest New Drugs. 2012 Apr;30(2):846-52. doi: 10.1007/s10637-010-9612-2. Epub 2010 Dec 16. Invest New Drugs. 2012. PMID: 21161326
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