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IAPP Marks Mono-hormonal Stem-cell Derived β Cells that Maintain Stable Insulin Production in vitro and in vivo.
Davis JC, Ryaboshapkina M, Kenty JH, Eser PÖ, Menon S, Tyrberg B, Melton DA. Davis JC, et al. Among authors: melton da. bioRxiv [Preprint]. 2024 Apr 11:2024.04.10.587726. doi: 10.1101/2024.04.10.587726. bioRxiv. 2024. PMID: 38645166 Free PMC article. Preprint.
IAPP(+) cells had more mature beta cell gene expression and higher cellular insulin content than IAPP(-) cells in vitro. IAPP(+) INS(+) cells were more stable in long-term culture than IAPP(-) INS(+) cells and retained insulin expression after transplantation into mice. .. …
IAPP(+) cells had more mature beta cell gene expression and higher cellular insulin content than IAPP(-) cells in vitro. IAPP(+) INS(+) cell …
A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion.
Yang K, O'Cearbhaill ED, Liu SS, Zhou A, Chitnis GD, Hamilos AE, Xu J, Verma MKS, Giraldo JA, Kudo Y, Lee EA, Lee Y, Pop R, Langer R, Melton DA, Greiner DL, Karp JM. Yang K, et al. Among authors: melton da. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2101258118. doi: 10.1073/pnas.2101258118. Proc Natl Acad Sci U S A. 2021. PMID: 34504013 Free PMC article.
Finally, to address potential translational barriers, we outlined future steps necessary to optimize the ceMED design for long-term efficacy and clinical utility....
Finally, to address potential translational barriers, we outlined future steps necessary to optimize the ceMED design for long-term e …
Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice.
Walker RG, Barrandon O, Poggioli T, Dagdeviren S, Carroll SH, Mills MJ, Mendello KR, Gomez Y, Loffredo FS, Pancoast JR, Macias-Trevino C, Marts C, LeClair KB, Noh HL, Kim T, Banks AS, Kim JK, Cohen DE, Wagers AJ, Melton DA, Lee RT. Walker RG, et al. Among authors: melton da. Sci Rep. 2020 Mar 12;10(1):4561. doi: 10.1038/s41598-020-61443-y. Sci Rep. 2020. PMID: 32165710 Free PMC article.
To determine the metabolic effects of these two ligands, we administered rGDF11 or rGDF8 protein to young or aged mice fed a standard chow diet, short-term high-fat diet (HFD), or long-term HFD. Under nearly all of these diet conditions, administration of exogenous …
To determine the metabolic effects of these two ligands, we administered rGDF11 or rGDF8 protein to young or aged mice fed a standard chow d …
Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.
Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC. Alagpulinsa DA, et al. Among authors: melton da. Am J Transplant. 2019 Jul;19(7):1930-1940. doi: 10.1111/ajt.15308. Epub 2019 Mar 25. Am J Transplant. 2019. PMID: 30748094 Free article.
Additionally, SC-beta cells co-encapsulated with CXCL12 evaded the pericapsular fibrotic response, resulting in long-term functional competence and glycemic correction (>150 days) without systemic immunosuppression in immunocompetent C57BL/6 mice. ...
Additionally, SC-beta cells co-encapsulated with CXCL12 evaded the pericapsular fibrotic response, resulting in long-term functional …
Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Vegas AJ, et al. Among authors: melton da. Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446e. Nat Med. 2016. PMID: 27050590 No abstract available.
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice.
Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Vegas AJ, et al. Among authors: melton da. Nat Med. 2016 Mar;22(3):306-11. doi: 10.1038/nm.4030. Epub 2016 Jan 25. Nat Med. 2016. PMID: 26808346 Free PMC article.
However, clinical implementation has been challenging because of host immune responses to the implant materials. Here we report the first long-term glycemic correction of a diabetic, immunocompetent animal model using human SC-beta cells. ...
However, clinical implementation has been challenging because of host immune responses to the implant materials. Here we report the first lo …
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication.
Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA. Annes JP, et al. Among authors: melton da. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3915-20. doi: 10.1073/pnas.1201149109. Epub 2012 Feb 15. Proc Natl Acad Sci U S A. 2012. PMID: 22345561 Free PMC article.
Furthermore, the replication effect of ADK-Is is cell type-selective: treatment of islet cell cultures with ADK-Is increases replication of beta cells but not that of alpha cells, PP cells, or fibroblasts. Short-term in vivo treatment with an ADK-I also increases beta-cell …
Furthermore, the replication effect of ADK-Is is cell type-selective: treatment of islet cell cultures with ADK-Is increases replication of …