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Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology 2023 Focused Update of the Guidelines for the Use of Antiplatelet Therapy.
Primary Panel:; Bainey KR, Marquis-Gravel G, Belley-Côté E, Turgeon RD, Ackman ML, Babadagli HE, Bewick D, Boivin-Proulx LA, Cantor WJ, Fremes SE, Graham MM, Lordkipanidzé M, Madan M, Mansour S, Mehta SR, Potter BJ, Shavadia J, So DF, Tanguay JF, Welsh RC, Yan AT; Secondary Panel:; Bagai A, Bagur R, Bucci C, Elbarouni B, Geller C, Lavoie A, Lawler P, Liu S, Mancini J, Wong GC. Primary Panel:, et al. Among authors: mehta sr. Can J Cardiol. 2024 Feb;40(2):160-181. doi: 10.1016/j.cjca.2023.10.013. Epub 2023 Oct 29. Can J Cardiol. 2024. PMID: 38104631
Appended, the focused update of the Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology guidelines for the use of APT provides recommendations on the following topics: (1) use of acetylsalicylic acid in primary prevention of atherosclerotic cardiovas …
Appended, the focused update of the Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology guidelines for the use …
Biolimus-eluting vs. other limus-eluting stents in NSTE-ACS: A pooled analysis of GLASSY and TWILIGHT.
Spirito A, Valgimigli M, Cao D, Baber U, Mehta SR, Gibson CM, Steg GP, Sharma SK, Goel R, Huber K, Kunadian V, Escaned J, Franzone A, Yaling H, Collier T, Kaul U, Kornowski R, Krucoff M, Moliterno D, Sartori S, Owen R, Zhang Z, Dangas GD, Kastrati A, Angiolillo DJ, Cohen DJ, Vranckx P, Windecker S, Pocock S, Mehran R. Spirito A, et al. Among authors: mehta sr. Int J Cardiol. 2023 Jul 15;383:24-32. doi: 10.1016/j.ijcard.2023.04.027. Epub 2023 Apr 18. Int J Cardiol. 2023. PMID: 37080466
To account for trial design differences, outcomes were assessed at 3 months (short-term) and between 3 and 12 months (long-term) after PCI and subsequently pooled to estimate the 12-month hazards. RESULTS: Of 7107 and 6053 NSTE-ACS patients included in the short- an …
To account for trial design differences, outcomes were assessed at 3 months (short-term) and between 3 and 12 months (long-term
Effects of routine early treatment with PCSK9 inhibitors in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: a randomised, double-blind, sham-controlled trial.
Mehta SR, Pare G, Lonn EM, Jolly SS, Natarajan MK, Pinilla-Echeverri N, Schwalm JD, Sheth TN, Sibbald M, Tsang M, Valettas N, Velianou JL, Lee SF, Ferdous T, Nauman S, Nguyen H, McCready T, McQueen MJ. Mehta SR, et al. EuroIntervention. 2022 Dec 2;18(11):e888-e896. doi: 10.4244/EIJ-D-22-00735. EuroIntervention. 2022. PMID: 36349701 Free PMC article. Clinical Trial.
A large trial is needed to determine if this simplified approach followed by long-term therapy improves cardiovascular outcomes in patients with acute STEMI. ...
A large trial is needed to determine if this simplified approach followed by long-term therapy improves cardiovascular outcomes in pa …
The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.
ACTIV-3/TICO Study Group; Rogers AJ, Wentworth D, Phillips A, Shaw-Saliba K, Dewar RL, Aggarwal NR, Babiker AG, Chang W, Dharan NJ, Davey VJ, Higgs ES, Gerry N, Ginde AA, Hayanga JWA, Highbarger H, Highbarger JL, Jain MK, Kan V, Kim K, Lallemand P, Leshnower BG, Lutaakome JK, Matthews G, Mourad A, Mylonakis E, Natarajan V, Padilla ML, Pandit LM, Paredes R, Pett S, Ramachandruni S, Rehman MT, Sherman BT, Files DC, Brown SM, Matthay MA, Thompson BT, Neaton JD, Lane HC, Lundgren JD. ACTIV-3/TICO Study Group, et al. Ann Intern Med. 2022 Oct;175(10):1401-1410. doi: 10.7326/M22-0924. Epub 2022 Aug 30. Ann Intern Med. 2022. PMID: 36037469 Free PMC article.
OBJECTIVE: To evaluate whether levels of plasma antigen can predict short-term clinical outcomes and identify clinical and viral factors associated with plasma antigen levels in hospitalized patients with SARS-CoV-2. ...
OBJECTIVE: To evaluate whether levels of plasma antigen can predict short-term clinical outcomes and identify clinical and viral fact …
Complete revascularization in stable multivessel coronary artery disease: A real world analysis from the British Columbia Cardiac Registry.
Iqbal MB, Moore PT, Nadra IJ, Robinson SD, Fretz E, Ding L, Fung A, Aymong E, Chan AW, Hodge S, Webb J, Sheth T, Jolly SS, Mehta SR, Sathananthan J, Wood DA, Della Siega A; British Columbia Cardiac Registry Investigators. Iqbal MB, et al. Among authors: mehta sr. Catheter Cardiovasc Interv. 2022 Feb;99(3):627-638. doi: 10.1002/ccd.29564. Epub 2021 Mar 4. Catheter Cardiovasc Interv. 2022. PMID: 33660326
CONCLUSIONS: In this study of stable patients with MVD, CR was an independent predictor of long-term survival. This benefit was specifically seen in higher risk patient groups and indicates that CR may benefit selected stable patients with MVD....
CONCLUSIONS: In this study of stable patients with MVD, CR was an independent predictor of long-term survival. This benefit was speci …
Telomere length is associated with HIV infection, methamphetamine use, inflammation, and comorbid disease risk.
Mehta SR, Iudicello JE, Lin J, Ellis RJ, Morgan E, Okwuegbuna O, Cookson D, Karris M, Saloner R, Heaton R, Grant I, Letendre S; TMARC Group. Mehta SR, et al. Drug Alcohol Depend. 2021 Apr 1;221:108639. doi: 10.1016/j.drugalcdep.2021.108639. Epub 2021 Feb 16. Drug Alcohol Depend. 2021. PMID: 33621803 Free PMC article.
While not establishing causality, this study supports using the T/S ratio as a biomarker for estimating the impact of HIV and comorbidities on long-term health....
While not establishing causality, this study supports using the T/S ratio as a biomarker for estimating the impact of HIV and comorbidities …
Timing of Staged Nonculprit Artery Revascularization in Patients With ST-Segment Elevation Myocardial Infarction: COMPLETE Trial.
Wood DA, Cairns JA, Wang J, Mehran R, Storey RF, Nguyen H, Meeks B, Kunadian V, Tanguay JF, Kim HH, Cheema A, Dehghani P, Natarajan MK, Jolly SS, Amerena J, Keltai M, James S, Hlinomaz O, Niemela K, AlHabib K, Lewis BS, Nguyen M, Sarma J, Dzavik V, Della Siega A, Mehta SR; COMPLETE Investigators. Wood DA, et al. Among authors: mehta sr. J Am Coll Cardiol. 2019 Dec 3;74(22):2713-2723. doi: 10.1016/j.jacc.2019.09.051. J Am Coll Cardiol. 2019. PMID: 31779786 Free article. Clinical Trial.
The benefit of complete revascularization on hard clinical outcomes emerged mainly over the long term....
The benefit of complete revascularization on hard clinical outcomes emerged mainly over the long term....
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial.
Bhatt DL, Steg PG, Mehta SR, Leiter LA, Simon T, Fox K, Held C, Andersson M, Himmelmann A, Ridderstråle W, Chen J, Song Y, Diaz R, Goto S, James SK, Ray KK, Parkhomenko AN, Kosiborod MN, McGuire DK, Harrington RA; THEMIS Steering Committee and Investigators. Bhatt DL, et al. Among authors: mehta sr. Lancet. 2019 Sep 28;394(10204):1169-1180. doi: 10.1016/S0140-6736(19)31887-2. Epub 2019 Sep 1. Lancet. 2019. PMID: 31484629 Free article. Clinical Trial.
In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes …
In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of …
Clinical Outcomes Following Implantation of Thin-Strut, Bioabsorbable Polymer-Coated, Everolimus-Eluting SYNERGY Stents.
Kereiakes DJ, Windecker S, Jobe RL, Mehta SR, Sarembock IJ, Feldman RL, Stein B, Dubois C, Grady T, Saito S, Kimura T, Underwood P, Allocco DJ, Meredith IT. Kereiakes DJ, et al. Among authors: mehta sr. Circ Cardiovasc Interv. 2019 Sep;12(9):e008152. doi: 10.1161/CIRCINTERVENTIONS.119.008152. Epub 2019 Aug 27. Circ Cardiovasc Interv. 2019. PMID: 31451014 Clinical Trial.
In the multicenter, randomized EVOLVE II trial (The EVOLVE II Clinical Trial to Assess the SYNERGY Stent System for the Treatment of Atherosclerotic Lesion[s]), SYNERGY was noninferior to the durable polymer PROMUS Element Plus everolimus-eluting stent for the primary end point o …
In the multicenter, randomized EVOLVE II trial (The EVOLVE II Clinical Trial to Assess the SYNERGY Stent System for the Treatment of Atheros …
Analyses of Mitochondrial DNA and Immune Phenotyping Suggest Accelerated T-Cell Turnover in Treated HIV.
Massanella M, Karris MY, Pérez-Santiago J, Yek C, Vitomirov A, Mehta SR. Massanella M, et al. Among authors: mehta sr. J Acquir Immune Defic Syndr. 2018 Nov 1;79(3):399-406. doi: 10.1097/QAI.0000000000001824. J Acquir Immune Defic Syndr. 2018. PMID: 30312276 Free PMC article.
Because mitochondrial toxicity is a consequence of antiretroviral therapies (ARTs), we hypothesized HIV and long-term ART would correlate with immunosenescence and mitochondrial DNA (mtDNA) pathology. ...
Because mitochondrial toxicity is a consequence of antiretroviral therapies (ARTs), we hypothesized HIV and long-term ART would corre …
35 results