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Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up.
Mathers JC, Elliott F, Macrae F, Mecklin JP, Möslein G, McRonald FE, Bertario L, Evans DG, Gerdes AM, Ho JWC, Lindblom A, Morrison PJ, Rashbass J, Ramesar RS, Seppälä TT, Thomas HJW, Sheth HJ, Pylvänäinen K, Reed L, Borthwick GM, Bishop DT, Burn J; CAPP2 Investigators. Mathers JC, et al. Among authors: mecklin jp. Cancer Prev Res (Phila). 2022 Sep 1;15(9):623-634. doi: 10.1158/1940-6207.CAPR-22-0044. Cancer Prev Res (Phila). 2022. PMID: 35878732 Free PMC article. Clinical Trial.
ABSTRACT: The CAPP2 trial investigated the long-term effects of aspirin and resistant starch on cancer incidence in patients with Lynch syndrome (LS). Participants with LS were randomized double-blind to 30 g resistant starch (RS) daily or placebo for up to 4 years. We pre …
ABSTRACT: The CAPP2 trial investigated the long-term effects of aspirin and resistant starch on cancer incidence in patients with Lyn …
The Different Immune Profiles of Normal Colonic Mucosa in Cancer-Free Lynch Syndrome Carriers and Lynch Syndrome Colorectal Cancer Patients.
Bohaumilitzky L, Kluck K, Hüneburg R, Gallon R, Nattermann J, Kirchner M, Kristiansen G, Hommerding O, Pfuderer PL, Wagner L, Echterdiek F, Kösegi S, Müller N, Fischer K, Nelius N, Hartog B, Borthwick G, Busch E, Haag GM, Bläker H, Möslein G, von Knebel Doeberitz M, Seppälä TT, Ahtiainen M, Mecklin JP, Bishop DT, Burn J, Stenzinger A, Budczies J, Kloor M, Ahadova A. Bohaumilitzky L, et al. Among authors: mecklin jp. Gastroenterology. 2022 Mar;162(3):907-919.e10. doi: 10.1053/j.gastro.2021.11.029. Epub 2021 Dec 2. Gastroenterology. 2022. PMID: 34863788
Gene expression profiling and cluster analysis revealed distinct immune profiles in LS carrier mucosa with and without cancer manifestation. Long-term follow-up of LS carriers within the CAPP2 trial found a correlation between mucosal T-cell infiltrate and time to subseque …
Gene expression profiling and cluster analysis revealed distinct immune profiles in LS carrier mucosa with and without cancer manifestation. …
Body Weight, Physical Activity, and Risk of Cancer in Lynch Syndrome.
Sievänen T, Törmäkangas T, Laakkonen EK, Mecklin JP, Pylvänäinen K, Seppälä TT, Peltomäki P, Sipilä S, Sillanpää E. Sievänen T, et al. Among authors: mecklin jp. Cancers (Basel). 2021 Apr 13;13(8):1849. doi: 10.3390/cancers13081849. Cancers (Basel). 2021. PMID: 33924417 Free PMC article.
Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term changes in body weight and PA using extended Cox regression models. The longitudinal weight change was associated with an increased ris …
Overall cancer risk and colorectal cancer (CRC) risk was analyzed separately for men and women with respect to longitudinal and near-term …
Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial.
Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin JP, Möslein G, McRonald FE, Bertario L, Evans DG, Gerdes AM, Ho JWC, Lindblom A, Morrison PJ, Rashbass J, Ramesar R, Seppälä T, Thomas HJW, Pylvänäinen K, Borthwick GM, Mathers JC, Bishop DT; CAPP2 Investigators. Burn J, et al. Among authors: mecklin jp. Lancet. 2020 Jun 13;395(10240):1855-1863. doi: 10.1016/S0140-6736(20)30366-4. Lancet. 2020. PMID: 32534647 Free PMC article. Clinical Trial.
BACKGROUND: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55.7 months [SD 31.4]) for participants with Ly …
BACKGROUND: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endo …
Quality of Life and Patient Satisfaction at 7-Year Follow-up of Antibiotic Therapy vs Appendectomy for Uncomplicated Acute Appendicitis: A Secondary Analysis of a Randomized Clinical Trial.
Sippola S, Haijanen J, Viinikainen L, Grönroos J, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Hurme S, Mecklin JP, Sand J, Jartti A, Salminen P. Sippola S, et al. Among authors: mecklin jp. JAMA Surg. 2020 Apr 1;155(4):283-289. doi: 10.1001/jamasurg.2019.6028. JAMA Surg. 2020. PMID: 32074268 Free PMC article. Clinical Trial.
IMPORTANCE: Long-term results support antibiotics for uncomplicated acute appendicitis as an alternative to appendectomy. To our knowledge, treatment-related long-term patient satisfaction and quality of life (QOL) are not known. ...
IMPORTANCE: Long-term results support antibiotics for uncomplicated acute appendicitis as an alternative to appendectomy. To our know …
Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial.
Salminen P, Tuominen R, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T, Hurme S, Mecklin JP, Sand J, Virtanen J, Jartti A, Grönroos JM. Salminen P, et al. Among authors: mecklin jp. JAMA. 2018 Sep 25;320(12):1259-1265. doi: 10.1001/jama.2018.13201. JAMA. 2018. PMID: 30264120 Free PMC article. Clinical Trial.
IMPORTANCE: Short-term results support antibiotics as an alternative to surgery for treating uncomplicated acute appendicitis, but long-term outcomes are not known. ...CONCLUSIONS AND RELEVANCE: Among patients who were initially treated with antibiotics for uncompli …
IMPORTANCE: Short-term results support antibiotics as an alternative to surgery for treating uncomplicated acute appendicitis, but lo …
Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome.
Renkonen-Sinisalo L, Seppälä TT, Järvinen HJ, Mecklin JP. Renkonen-Sinisalo L, et al. Among authors: mecklin jp. Dis Colon Rectum. 2017 Aug;60(8):792-799. doi: 10.1097/DCR.0000000000000802. Dis Colon Rectum. 2017. PMID: 28682964
OBJECTIVE: This study aimed to examine whether extended surgery decreases the risk of subsequent colorectal cancer and improves long-term survival. DESIGN: This was a retrospective study. SETTING: Data were collected from a nationwide registry. ...
OBJECTIVE: This study aimed to examine whether extended surgery decreases the risk of subsequent colorectal cancer and improves long-term …
Evaluation of a fast-track protocol for patients undergoing colorectal surgery.
Ehrlich A, Wagner B, Kairaluoma M, Mecklin JP, Kautiainen H, Kellokumpu I. Ehrlich A, et al. Among authors: mecklin jp. Scand J Surg. 2014 Sep;103(3):182-188. doi: 10.1177/1457496913516295. Epub 2014 Apr 2. Scand J Surg. 2014. PMID: 24694778
BACKGROUND AND AIMS: Fast-track protocols have been used to optimize the perioperative care and to enhance postoperative recovery. This study examined short-term clinical outcomes and determinants affecting the length of postoperative hospital stay. ...
BACKGROUND AND AIMS: Fast-track protocols have been used to optimize the perioperative care and to enhance postoperative recovery. This stud …
Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study.
Aktan-Collan K, Kääriäinen H, Järvinen H, Peltomäki P, Pylvänäinen K, Mecklin JP, Haukkala A. Aktan-Collan K, et al. Among authors: mecklin jp. Fam Cancer. 2013 Dec;12(4):639-46. doi: 10.1007/s10689-013-9628-9. Fam Cancer. 2013. PMID: 23512527
We evaluated long-term psychosocial consequences of predictive genetic testing, and surveillance behaviour in Lynch syndrome (LS). ...
We evaluated long-term psychosocial consequences of predictive genetic testing, and surveillance behaviour in Lynch syndrome (LS). .. …
Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial.
Mathers JC, Movahedi M, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans G, Maher ER, Bertario L, Bisgaard ML, Dunlop M, Ho JW, Hodgson S, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen H, Gerdes AM, Barker G, Crawford G, Elliott F, Pylvanainen K, Wijnen J, Fodde R, Lynch H, Bishop DT, Burn J; CAPP2 Investigators. Mathers JC, et al. Among authors: mecklin jp. Lancet Oncol. 2012 Dec;13(12):1242-9. doi: 10.1016/S1470-2045(12)70475-8. Epub 2012 Nov 7. Lancet Oncol. 2012. PMID: 23140761 Free article. Clinical Trial.
18 results