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Endothelial abnormalities in adolescents with type 1 diabetes: a biomarker for vascular sequelae?
DiMeglio LA, Tosh A, Saha C, Estes M, Mund J, Mead LE, Lien I, Ingram DA, Haneline LS. DiMeglio LA, et al. Among authors: mead le. J Pediatr. 2010 Oct;157(4):540-6. doi: 10.1016/j.jpeds.2010.04.050. Epub 2010 Jun 12. J Pediatr. 2010. PMID: 20542287 Free PMC article.
Endothelium-dependent vasodilation was impaired in subjects with diabetes, which correlated with reductions in circulating CD34+CD133+CD31+ cells. CONCLUSIONS: Long-term sequelae of type 1 diabetes include vasculopathies. Endothelial progenitor cells promote vascular healt …
Endothelium-dependent vasodilation was impaired in subjects with diabetes, which correlated with reductions in circulating CD34+CD133+CD31+ …
Endothelial colony-forming cells and mesenchymal stem cells from ECMO circuits of term infants.
Hoesli SJ, Mead LE, Prater D, Javed MJ, Ingram DA, Denne SC. Hoesli SJ, et al. Among authors: mead le. J Perinatol. 2010 Nov;30(11):724-30. doi: 10.1038/jp.2010.35. Epub 2010 Mar 25. J Perinatol. 2010. PMID: 20336079
CONCLUSION: To our knowledge, this is the first report of ECFCs and MSCs isolated from peripheral blood of critically ill term newborns. Both cells types may be mobilized in response to critical illness or to the ECMO circuit. ...
CONCLUSION: To our knowledge, this is the first report of ECFCs and MSCs isolated from peripheral blood of critically ill term newbor …
Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood.
Javed MJ, Mead LE, Prater D, Bessler WK, Foster D, Case J, Goebel WS, Yoder MC, Haneline LS, Ingram DA. Javed MJ, et al. Among authors: mead le. Pediatr Res. 2008 Jul;64(1):68-73. doi: 10.1203/PDR.0b013e31817445e9. Pediatr Res. 2008. PMID: 18360305
Previous studies show that hematopoietic progenitor cells are increased in premature UCB compared with term controls. Based on this paradigm, we hypothesized that premature UCB would be an enriched source of ECFCs. ...GA of 33-36 wk UCB yielded predominantly ECFC colonies …
Previous studies show that hematopoietic progenitor cells are increased in premature UCB compared with term controls. Based on this p …
In vitro hyperglycemia or a diabetic intrauterine environment reduces neonatal endothelial colony-forming cell numbers and function.
Ingram DA, Lien IZ, Mead LE, Estes M, Prater DN, Derr-Yellin E, DiMeglio LA, Haneline LS. Ingram DA, et al. Among authors: mead le. Diabetes. 2008 Mar;57(3):724-31. doi: 10.2337/db07-1507. Epub 2007 Dec 17. Diabetes. 2008. PMID: 18086900
OBJECTIVE: Emerging data demonstrate that maternal diabetes has long-term health consequences for offspring, including the development of hypertension. ...CONCLUSIONS; Collectively, these data demonstrate that hyperglycemia or exposure to a diabetic intrauterine environmen …
OBJECTIVE: Emerging data demonstrate that maternal diabetes has long-term health consequences for offspring, including the developmen …
Cord blood stem and progenitor cells.
Broxmeyer HE, Srour E, Orschell C, Ingram DA, Cooper S, Plett PA, Mead LE, Yoder MC. Broxmeyer HE, et al. Among authors: mead le. Methods Enzymol. 2006;419:439-73. doi: 10.1016/S0076-6879(06)19018-7. Methods Enzymol. 2006. PMID: 17141066 Review.
Specifically, methods are presented for enumerating human cord blood myeloid progenitor cells, including granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and multipotential (CFU-GEMM or CFU-Mix) progenitors, and their replating potential; hematopoietic stem cells, as assessed …
Specifically, methods are presented for enumerating human cord blood myeloid progenitor cells, including granulocyte-macrophage (CFU-GM), er …