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Intermittent screening and treatment for malaria complementary to routine immunisation in the first year of life in Papua, Indonesia: a cluster randomised superiority trial.
Poespoprodjo JR, Hafiidhaturrahmah, Sariyanti N, Indrawanti R, McLean ARD, Simpson JA, Kenangalem E, Burdam FH, Noviyanti R, Trianty L, Fadhilah C, Soenarto Y, Price RN. Poespoprodjo JR, et al. Among authors: mclean ard. BMC Med. 2022 Jun 8;20(1):190. doi: 10.1186/s12916-022-02394-1. BMC Med. 2022. PMID: 35672703 Free PMC article. Clinical Trial.
A total of 21 clusters of village health posts (VHP) were randomised 1:1 to either IST for infants coinciding with 4 routine immunisation visits or PCDi. Healthy term infants born to consenting mothers enrolled into a maternal malaria cluster randomised trial were included …
A total of 21 clusters of village health posts (VHP) were randomised 1:1 to either IST for infants coinciding with 4 routine immunisation vi …
The impact of antiretroviral therapy on population-level virulence evolution of HIV-1.
Roberts HE, Goulder PJ, McLean AR. Roberts HE, et al. Among authors: mclean ar. J R Soc Interface. 2015 Dec 6;12(113):20150888. doi: 10.1098/rsif.2015.0888. J R Soc Interface. 2015. PMID: 26609066 Free PMC article.
Transient decreases in virulence following the peak of an epidemic are not necessarily indicative of eventual evolution to avirulence. In the short term, we would expect widespread ART to cause limited downward pressure on virulence. In the long term, the direction …
Transient decreases in virulence following the peak of an epidemic are not necessarily indicative of eventual evolution to avirulence. In th …
Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids.
San Millan A, Peña-Miller R, Toll-Riera M, Halbert ZV, McLean AR, Cooper BS, MacLean RC. San Millan A, et al. Among authors: mclean ar. Nat Commun. 2014 Oct 10;5:5208. doi: 10.1038/ncomms6208. Nat Commun. 2014. PMID: 25302567 Free PMC article.
Plasmids are important drivers of bacterial evolution, but it is challenging to understand how plasmids persist over the long term because plasmid carriage is costly. Classical models predict that horizontal transfer is necessary for plasmid persistence, but recent work sh …
Plasmids are important drivers of bacterial evolution, but it is challenging to understand how plasmids persist over the long term be …
Low rate of delayed deterioration requiring surgical treatment in patients transferred to a tertiary care center for mild traumatic brain injury.
Carlson AP, Ramirez P, Kennedy G, McLean AR, Murray-Krezan C, Stippler M. Carlson AP, et al. Among authors: mclean ar. Neurosurg Focus. 2010 Nov;29(5):E3. doi: 10.3171/2010.8.FOCUS10182. Neurosurg Focus. 2010. PMID: 21039137 Free PMC article.
Information including demographic data, lesion type, need for neurosurgical intervention, and short-term outcome was recorded. RESULTS: During the 4-year study period, 292 patients (age range newborn to 92 years) were transferred for evaluation of mTBI. ...
Information including demographic data, lesion type, need for neurosurgical intervention, and short-term outcome was recorded. RESULT …
Mathematical modelling of effectiveness.
McLean AR. McLean AR. Dev Biol Stand. 1998;95:225-33. Dev Biol Stand. 1998. PMID: 9855436
Effectiveness certainly includes efficacy, but also encompasses secondary effects of vaccination, long-term efficacy of a vaccine (beyond that measured in conventional efficacy trials), the impact of vaccinating against one strain upon cross-reacting infections, costs of v …
Effectiveness certainly includes efficacy, but also encompasses secondary effects of vaccination, long-term efficacy of a vaccine (be …
The regulation of malaria parasitaemia: parameter estimates for a population model.
Gravenor MB, McLean AR, Kwiatkowski D. Gravenor MB, et al. Among authors: mclean ar. Parasitology. 1995 Feb;110 ( Pt 2):115-22. doi: 10.1017/s0031182000063861. Parasitology. 1995. PMID: 7885729
Our results show that competition cannot account for the total regulation of P. falciparum, but when combined with immune mechanisms it may play a more important role than is generally supposed. Further analysis of the model indicates that in the long term, parasite replic …
Our results show that competition cannot account for the total regulation of P. falciparum, but when combined with immune mechanisms it may …
Modelling T cell memory.
McLean AR. McLean AR. J Theor Biol. 1994 Sep 7;170(1):63-74. doi: 10.1006/jtbi.1994.1168. J Theor Biol. 1994. PMID: 7967635
A threshold is derived for the number of cells that must be transferred in order to transfer long-term immune memory from one animal to another. The existence of such a threshold implies that when small numbers of cells are transferred, or the transferred cells are in the …
A threshold is derived for the number of cells that must be transferred in order to transfer long-term immune memory from one animal …
Quasispecies dynamics and the emergence of drug resistance during zidovudine therapy of HIV infection.
Frost SD, McLean AR. Frost SD, et al. Among authors: mclean ar. AIDS. 1994 Mar;8(3):323-32. doi: 10.1097/00002030-199403000-00005. AIDS. 1994. PMID: 7913327
When the populations of infected and uninfected cells approach their treatment equilibrium levels, mutation again becomes important in the slow generation of highly resistant strains. CONCLUSIONS: The short-term reduction in viral replication at the initiation of therapy g …
When the populations of infected and uninfected cells approach their treatment equilibrium levels, mutation again becomes important in the s …