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Topical Application of Naltrexone to the Ocular Surface of Healthy Volunteers: A Tolerability Study.
Liang D, Sassani JW, McLaughlin PJ, Zagon IS. Liang D, et al. Among authors: mclaughlin pj. J Ocul Pharmacol Ther. 2016 Mar;32(2):127-32. doi: 10.1089/jop.2015.0070. Epub 2016 Jan 7. J Ocul Pharmacol Ther. 2016. PMID: 26741052 Clinical Trial.
PURPOSE: A short-term, randomized double-masked study was conducted to test the tolerability of topical application of naltrexone to the corneal surface. ...
PURPOSE: A short-term, randomized double-masked study was conducted to test the tolerability of topical application of naltrexone to …
Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure.
Packer M, Colucci W, Fisher L, Massie BM, Teerlink JR, Young J, Padley RJ, Thakkar R, Delgado-Herrera L, Salon J, Garratt C, Huang B, Sarapohja T; REVIVE Heart Failure Study Group. Packer M, et al. JACC Heart Fail. 2013 Apr;1(2):103-11. doi: 10.1016/j.jchf.2012.12.004. Epub 2013 Apr 1. JACC Heart Fail. 2013. PMID: 24621834 Free article. Clinical Trial.
(Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure; NCT00048425)....
(Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure; NCT00048425)....
Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor pathway to inhibit cell proliferation: mechanistic evidence from a tissue culture model.
Donahue RN, McLaughlin PJ, Zagon IS. Donahue RN, et al. Among authors: mclaughlin pj. Exp Biol Med (Maywood). 2011 Sep;236(9):1036-50. doi: 10.1258/ebm.2011.011121. Epub 2011 Aug 1. Exp Biol Med (Maywood). 2011. PMID: 21807817
Sequential administration of short-term NTX and OGF had a greater inhibitory effect on cell proliferation than either agent alone. Given the parallels between short-term NTX in vitro and LDN in vivo, we now demonstrate at the molecular level that the OGF-OGFr axis i …
Sequential administration of short-term NTX and OGF had a greater inhibitory effect on cell proliferation than either agent alone. Gi …
Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin.
Donahue RN, McLaughlin PJ, Zagon IS. Donahue RN, et al. Among authors: mclaughlin pj. Exp Biol Med (Maywood). 2011 Jul;236(7):883-95. doi: 10.1258/ebm.2011.011096. Epub 2011 Jun 17. Exp Biol Med (Maywood). 2011. PMID: 21685240
LDN treatment upregulated the expression of the opioid growth factor (OGF, chemical term ([Met(5)]-enkephalin) and its receptor, OGFr. Previous tissue culture studies have reported that OGF is the only opioid peptide with antiproliferative activity on ovarian cancer cells, …
LDN treatment upregulated the expression of the opioid growth factor (OGF, chemical term ([Met(5)]-enkephalin) and its receptor, OGFr …
Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF) for an extended period: Therapeutic implications for multiple sclerosis.
Rahn KA, McLaughlin PJ, Zagon IS. Rahn KA, et al. Among authors: mclaughlin pj. Brain Res. 2011 Mar 24;1381:243-53. doi: 10.1016/j.brainres.2011.01.036. Epub 2011 Jan 20. Brain Res. 2011. PMID: 21256121
Endogenous opioids inhibit the onset and progression of experimental autoimmune encephalomyelitis (EAE) with 30days of treatment. This study examined the long term effects of the opioid growth factor (OGF, [Met(5)]-enkephalin) and a low dose of the opioid antagonist naltre …
Endogenous opioids inhibit the onset and progression of experimental autoimmune encephalomyelitis (EAE) with 30days of treatment. This study …
Growth inhibition of thyroid follicular cell-derived cancers by the opioid growth factor (OGF) - opioid growth factor receptor (OGFr) axis.
McLaughlin PJ, Zagon IS, Park SS, Conway A, Donahue RN, Goldenberg D. McLaughlin PJ, et al. BMC Cancer. 2009 Oct 18;9:369. doi: 10.1186/1471-2407-9-369. BMC Cancer. 2009. PMID: 19835629 Free PMC article.
Follicular carcinoma (FTC) is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Opioid Growth Factor (OGF; chemical term - [Met5]-enkephalin) and its receptor, OGFr, form an inhibi …
Follicular carcinoma (FTC) is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one o …
Exposure to the opioid antagonist naltrexone throughout gestation alters postnatal heart development.
McLaughlin PJ. McLaughlin PJ. Biol Neonate. 2002;82(3):207-16. doi: 10.1159/000063611. Biol Neonate. 2002. PMID: 12373072
Pregnant Sprague-Dawley rats received daily injections of 50 mg/kg naltrexone (NTX) or saline throughout gestation; offspring were cross-fostered at birth to mothers not receiving NTX. In general, NTX-treated offspring weighed more than controls throughout preweaning life, …
Pregnant Sprague-Dawley rats received daily injections of 50 mg/kg naltrexone (NTX) or saline throughout gestation; offspring were cross-fos …
Transplacental transfer of the opioid growth factor, [Met(5)]-enkephalin, in rats.
Zagon IS, Wylie JD, Hurst WJ, McLaughlin PJ. Zagon IS, et al. Among authors: mclaughlin pj. Brain Res Bull. 2001 Jun;55(3):341-6. doi: 10.1016/s0361-9230(01)00518-4. Brain Res Bull. 2001. PMID: 11489341
Given that [Met5]-enkephalin tonically inhibits DNA synthesis in the fetus, these results raise the question of whether an elevated level of this peptide (either maternally or from the fetus) may be detrimental to cellular ontogeny in the fetus, and perhaps have long-term …
Given that [Met5]-enkephalin tonically inhibits DNA synthesis in the fetus, these results raise the question of whether an elevated level of …
Epithelial adhesion complexes and organ culture of the human cornea.
Zagon IS, Sassani JW, Ruth TB, McLaughlin PJ. Zagon IS, et al. Among authors: mclaughlin pj. Brain Res. 2001 May 11;900(2):205-13. doi: 10.1016/s0006-8993(01)02296-x. Brain Res. 2001. PMID: 11334799
These results indicate that the structural integrity of human corneal epithelium in organ culture is compromised after 14 days in vitro using an immersion system of tissue culture. Thus, long-term use of cultures to define homeostasis and wound healing of the ocular surfac …
These results indicate that the structural integrity of human corneal epithelium in organ culture is compromised after 14 days in vitro usin …
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