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Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer's disease in a mouse model of Aβ amyloidosis.
Karahan H, Smith DC, Kim B, Dabin LC, Al-Amin MM, Wijeratne HRS, Pennington T, Viana di Prisco G, McCord B, Lin PB, Li Y, Peng J, Oblak AL, Chu S, Atwood BK, Kim J. Karahan H, et al. Among authors: mccord b. Sci Adv. 2021 Nov 5;7(45):eabe3954. doi: 10.1126/sciadv.abe3954. Epub 2021 Nov 3. Sci Adv. 2021. PMID: 34731000 Free PMC article.
We demonstrate that the deletion of Abi3 locus significantly increases amyloid beta (Abeta) accumulation and decreases microglia clustering around the plaques. Furthermore, long-term potentiation is impaired in 5XFAD;Abi3 knockout ("Abi3(/)") mice. ...
We demonstrate that the deletion of Abi3 locus significantly increases amyloid beta (Abeta) accumulation and decreases microglia clustering …
Long term renal prognosis of Henoch-Schonlein purpura in an unselected childhood population.
Stewart M, Savage JM, Bell B, McCord B. Stewart M, et al. Among authors: mccord b. Eur J Pediatr. 1988 Feb;147(2):113-5. doi: 10.1007/BF00442205. Eur J Pediatr. 1988. PMID: 3366130
The overall prognosis in this unselected population is therefore good with a mortality less than 1% overall and low long term morbidity of 1.1%. This study indicates a more optimistic outcome in this condition than the majority of published estimates based on more selected …
The overall prognosis in this unselected population is therefore good with a mortality less than 1% overall and low long term morbidi …