Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

31 results

Filters applied: . Clear all
Page 1
A Fundamental Role for Oxidants and Intracellular Calcium Signals in Alzheimer's Pathogenesis-And How a Comprehensive Antioxidant Strategy May Aid Prevention of This Disorder.
McCarty MF, DiNicolantonio JJ, Lerner A. McCarty MF, et al. Int J Mol Sci. 2021 Feb 21;22(4):2140. doi: 10.3390/ijms22042140. Int J Mol Sci. 2021. PMID: 33669995 Free PMC article. Review.
Conceivably, complementing such lifestyle measures with long-term adherence to the sort of nutraceutical regimen outlined here may drive down risk for AD even further....
Conceivably, complementing such lifestyle measures with long-term adherence to the sort of nutraceutical regimen outlined here may dr …
Neuroprotective potential of high-dose biotin.
McCarty MF, DiNicolantonio JJ. McCarty MF, et al. Med Hypotheses. 2017 Nov;109:145-149. doi: 10.1016/j.mehy.2017.10.012. Epub 2017 Oct 16. Med Hypotheses. 2017. PMID: 29150274
In many types of neurons and neural cells, cGMP exerts neurotrophic-mimetic effects - entailing activation of the PI3K-Akt and Ras-ERK pathways - that promote neuron survival and plasticity. Hippocampal long term potentiation requires nitric oxide synthesis, which in turn …
In many types of neurons and neural cells, cGMP exerts neurotrophic-mimetic effects - entailing activation of the PI3K-Akt and Ras-ERK pathw …
Asymmetric Dimethylarginine Is a Well Established Mediating Risk Factor for Cardiovascular Morbidity and Mortality-Should Patients with Elevated Levels Be Supplemented with Citrulline?
McCarty MF. McCarty MF. Healthcare (Basel). 2016 Jul 8;4(3):40. doi: 10.3390/healthcare4030040. Healthcare (Basel). 2016. PMID: 27417628 Free PMC article. Review.
Fortunately, the suppressive impact of ADMA on eNOS activity can be offset by increasing intracellular arginine levels with supplemental citrulline. Although the long-term impact of supplemental citrulline on cardiovascular health in patients with elevated ADMA has not yet …
Fortunately, the suppressive impact of ADMA on eNOS activity can be offset by increasing intracellular arginine levels with supplemental cit …
The moderate essential amino acid restriction entailed by low-protein vegan diets may promote vascular health by stimulating FGF21 secretion.
McCarty MF. McCarty MF. Horm Mol Biol Clin Investig. 2016 Feb 12;30(1):/j/hmbci.2017.30.issue-1/hmbci-2015-0056/hmbci-2015-0056.xml. doi: 10.1515/hmbci-2015-0056. Horm Mol Biol Clin Investig. 2016. PMID: 26872317 Review.
The serum total and LDL cholesterol levels of long-term vegans tend to be very low. The characteristically low ratio of saturated to unsaturated fat in vegan diets, and the absence of cholesterol in such diets, clearly contribute to this effect. ...
The serum total and LDL cholesterol levels of long-term vegans tend to be very low. The characteristically low ratio of saturated to …
Coenzyme Q10 for the treatment of heart failure: a review of the literature.
DiNicolantonio JJ, Bhutani J, McCarty MF, O'Keefe JH. DiNicolantonio JJ, et al. Among authors: mccarty mf. Open Heart. 2015 Oct 19;2(1):e000326. doi: 10.1136/openhrt-2015-000326. eCollection 2015. Open Heart. 2015. PMID: 26512330 Free PMC article. Review.
A total of 420 patients received either CoQ10 (100 mg three times daily) or placebo and were followed for 2 years. Although short-term functional endpoints were not statistically different in the two groups, CoQ10 significantly reduced the primary long-term endpoint …
A total of 420 patients received either CoQ10 (100 mg three times daily) or placebo and were followed for 2 years. Although short-term …
An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly.
McCarty MF, DiNicolantonio JJ. McCarty MF, et al. Age (Dordr). 2015 Oct;37(5):96. doi: 10.1007/s11357-015-9823-8. Epub 2015 Sep 11. Age (Dordr). 2015. PMID: 26362762 Free PMC article. Review.
Increased efficiency of protein translation reflecting increased leucine intake and consequent greater mTORC1 activity may play a role in this effect; however, at present there is little solid evidence that leucine supplementation provides important long-term benefits to t …
Increased efficiency of protein translation reflecting increased leucine intake and consequent greater mTORC1 activity may play a role in th …
The protection conferred by chelation therapy in post-MI diabetics might be replicated by high-dose zinc supplementation.
McCarty MF, DiNicolantonio JJ. McCarty MF, et al. Med Hypotheses. 2015 May;84(5):451-5. doi: 10.1016/j.mehy.2015.01.038. Epub 2015 Jan 31. Med Hypotheses. 2015. PMID: 25682188
Zinc supplementation also modestly improves glycemic control in type 2 diabetics, and might reduce risk for diabetes by protecting pancreatic beta cells from oxidative stress. A long term study assessing the impact of supplementing diabetics with high-dose zinc, assessing …
Zinc supplementation also modestly improves glycemic control in type 2 diabetics, and might reduce risk for diabetes by protecting pancreati …
Potential ghrelin-mediated benefits and risks of hydrogen water.
McCarty MF. McCarty MF. Med Hypotheses. 2015 Apr;84(4):350-5. doi: 10.1016/j.mehy.2015.01.018. Epub 2015 Jan 21. Med Hypotheses. 2015. PMID: 25649854
The stimulatory impact of ghrelin on GH-IGF-I activity, while potentially beneficial in sarcopenia or cachectic disorders, does raise concerns regarding the long-term impact of ghrelin up-regulation on cancer risk. The impact of ingesting HW water on ghrelin production in …
The stimulatory impact of ghrelin on GH-IGF-I activity, while potentially beneficial in sarcopenia or cachectic disorders, does raise concer …
A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas.
DiNicolantonio JJ, McCarty MF, Chatterjee S, Lavie CJ, O'Keefe JH. DiNicolantonio JJ, et al. Among authors: mccarty mf. Nutr Cancer. 2014;66(8):1279-84. doi: 10.1080/01635581.2014.956262. Epub 2014 Oct 30. Nutr Cancer. 2014. PMID: 25356937
Analyses that focus on studies in which the upper category of fish consumption (not fried or salt-preserved) is 2 or more servings weekly, and on studies that evaluate the association of long-term fish oil supplementation with cancer risk yields a number of findings that a …
Analyses that focus on studies in which the upper category of fish consumption (not fried or salt-preserved) is 2 or more servings weekly, a …
AMPK activation--protean potential for boosting healthspan.
McCarty MF. McCarty MF. Age (Dordr). 2014 Apr;36(2):641-63. doi: 10.1007/s11357-013-9595-y. Epub 2013 Nov 19. Age (Dordr). 2014. PMID: 24248330 Free PMC article. Review.
AMPK activation is suspected to mediate some of the health-protective effects of long-term calorie restriction. Several drugs and nutraceuticals which slightly and safely impede the efficiency of mitochondrial ATP generation-most notably metformin and berberine-can be empl …
AMPK activation is suspected to mediate some of the health-protective effects of long-term calorie restriction. Several drugs and nut …
31 results