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Cognitive Trajectory Phenotypes in Human Immunodeficiency Virus-Infected Patients.
Dastgheyb RM, Sacktor N, Franklin D, Letendre S, Marcotte T, Heaton R, Grant I, McArthur JC, Rubin LH, Haughey NJ. Dastgheyb RM, et al. Among authors: mcarthur jc. J Acquir Immune Defic Syndr. 2019 Sep 1;82(1):61-70. doi: 10.1097/QAI.0000000000002093. J Acquir Immune Defic Syndr. 2019. PMID: 31107302 Free PMC article.
HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment.
Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. Saylor D, et al. Among authors: mcarthur jc. Nat Rev Neurol. 2016 Apr;12(4):234-48. doi: 10.1038/nrneurol.2016.27. Epub 2016 Mar 11. Nat Rev Neurol. 2016. PMID: 26965674 Free PMC article. Review.
Most importantly, the development and deployment of combination antiretroviral therapy (CART) has resulted in a dramatic decline in the rate of deaths from AIDS, so that people living with HIV today have nearly normal life expectancies if treated with CART. The term HIV-as …
Most importantly, the development and deployment of combination antiretroviral therapy (CART) has resulted in a dramatic decline in the rate …
Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients.
Ma Q, Vaida F, Wong J, Sanders CA, Kao YT, Croteau D, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, Morgello S, Simpson DM, Heaton RK, Grant I, Letendre SL; CHARTER Group. Ma Q, et al. Among authors: mcarthur jc. J Neurovirol. 2016 Apr;22(2):170-8. doi: 10.1007/s13365-015-0382-7. Epub 2015 Sep 25. J Neurovirol. 2016. PMID: 26407716 Free PMC article.
One contributing mechanism for this is antiretroviral neurotoxicity. Efavirenz (EFV) is associated with short-term central nervous system (CNS) toxicity, but less is known about its long-term effects. Our objective was to compare NC functioning with long-term …
One contributing mechanism for this is antiretroviral neurotoxicity. Efavirenz (EFV) is associated with short-term central nervous sy …
Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz.
Tovar-y-Romo LB, Bumpus NN, Pomerantz D, Avery LB, Sacktor N, McArthur JC, Haughey NJ. Tovar-y-Romo LB, et al. Among authors: mcarthur jc. J Pharmacol Exp Ther. 2012 Dec;343(3):696-703. doi: 10.1124/jpet.112.195701. Epub 2012 Sep 13. J Pharmacol Exp Ther. 2012. PMID: 22984227 Free PMC article.
However, it has also been proposed that the toxic effects of long-term cART may contribute to HAND. A better understanding of the neurotoxic potential of cART is critically needed in light of the use of CNS-penetrating cARTs to contend with the virus reservoir in the brain …
However, it has also been proposed that the toxic effects of long-term cART may contribute to HAND. A better understanding of the neu …
HIV-associated neurological disorders: a guide to pharmacotherapy.
Tan IL, McArthur JC. Tan IL, et al. Among authors: mcarthur jc. CNS Drugs. 2012 Feb 1;26(2):123-34. doi: 10.2165/11597770-000000000-00000. CNS Drugs. 2012. PMID: 22201342 Review.
In the era of highly active antiretroviral therapy (HAART), HIV-1-associated neurocognitive disorder (HAND) continues to be a common and significant morbidity among individuals infected with HIV. The term HAND encompasses a spectrum of progressively severe CNS involvement, …
In the era of highly active antiretroviral therapy (HAART), HIV-1-associated neurocognitive disorder (HAND) continues to be a common and sig …
Treatment of relapsing-remitting multiple sclerosis with high-dose cyclophosphamide induction followed by glatiramer acetate maintenance.
Harrison DM, Gladstone DE, Hammond E, Cheng J, Jones RJ, Brodsky RA, Kerr D, McArthur JC, Kaplin A. Harrison DM, et al. Among authors: mcarthur jc. Mult Scler. 2012 Feb;18(2):202-9. doi: 10.1177/1352458511419701. Epub 2011 Aug 24. Mult Scler. 2012. PMID: 21865410 Free PMC article.
BACKGROUND: Previous studies have described stabilization of aggressive multiple sclerosis (MS) with one-time induction therapy with high-dose cyclophosphamide (HiCy). The long-term benefit of this stabilization followed by conventional therapy has not been explored. ...A …
BACKGROUND: Previous studies have described stabilization of aggressive multiple sclerosis (MS) with one-time induction therapy with high-do …
Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy.
Ellis RJ, Marquie-Beck J, Delaney P, Alexander T, Clifford DB, McArthur JC, Simpson DM, Ake C, Collier AC, Gelman BB, McCutchan JA, Morgello S, Grant I; CHARTER Group. Ellis RJ, et al. Among authors: mcarthur jc. Ann Neurol. 2008 Nov;64(5):566-72. doi: 10.1002/ana.21484. Ann Neurol. 2008. PMID: 19067367 Free PMC article.
Confirmation of peripheral nerve toxicity with PIs could substantially limit their long-term use in highly active ARV therapy. METHODS: We evaluated current and past exposure to PIs as a risk factor for DSPN in 1,159 HIV-infected individuals enrolled in a large, prospectiv …
Confirmation of peripheral nerve toxicity with PIs could substantially limit their long-term use in highly active ARV therapy. METHOD …
Updated research nosology for HIV-associated neurocognitive disorders.
Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE. Antinori A, et al. Among authors: mcarthur jc. Neurology. 2007 Oct 30;69(18):1789-99. doi: 10.1212/01.WNL.0000287431.88658.8b. Epub 2007 Oct 3. Neurology. 2007. PMID: 17914061 Free PMC article.
It reviews our collective experience with HIV-associated neurocognitive disorders (HAND), particularly since the advent of highly active antiretroviral treatment, and their definitional criteria; discusses the impact of comorbidities; and suggests inclusion of the term asy …
It reviews our collective experience with HIV-associated neurocognitive disorders (HAND), particularly since the advent of highly active ant …
AIDS dementia complex in China.
Wu YC, Zhao YB, Tang MG, Zhang-Nunes SX, McArthur JC. Wu YC, et al. Among authors: mcarthur jc. J Clin Neurosci. 2007 Jan;14(1):8-11. doi: 10.1016/j.jocn.2005.07.012. Epub 2006 Oct 27. J Clin Neurosci. 2007. PMID: 17070055
We prospectively studied six patients with confirmed ADC out of a total of 36 AIDS patients treated from 1999 to 2003. All patients had short-term memory loss and poor concentration, with preserved alertness. ...
We prospectively studied six patients with confirmed ADC out of a total of 36 AIDS patients treated from 1999 to 2003. All patients had shor …
12 results