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Post-transcriptional regulation of cAMP-dependent protein kinase activity by cAMP in GH3 pituitary tumor cells. Evidence for increased degradation of catalytic subunit in the presence of cAMP.
Richardson JM, Howard P, Massa JS, Maurer RA. Richardson JM, et al. Among authors: maurer ra. J Biol Chem. 1990 Aug 15;265(23):13635-40. J Biol Chem. 1990. PMID: 2166038 Free article.
The increased degradation of the catalytic subunit was sufficient to account for the observed decreases in kinase activity. These results suggest that relatively long term cAMP treatment can alter total cAMP-dependent protein kinase activity through effects to alter the de …
The increased degradation of the catalytic subunit was sufficient to account for the observed decreases in kinase activity. These results su …