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An open-label extension of a phase 2 dose-finding study of once-weekly somatrogon vs. once-daily Genotropin in children with short stature due to growth hormone deficiency: results following 5 years of treatment.
Zadik Z, Zelinska N, Iotova V, Skorodok Y, Malievsky O, Mauras N, Valluri SR, Pastrak A, Rosenfeld R. Zadik Z, et al. Among authors: mauras n. J Pediatr Endocrinol Metab. 2023 Feb 3;36(3):261-269. doi: 10.1515/jpem-2022-0359. Print 2023 Mar 28. J Pediatr Endocrinol Metab. 2023. PMID: 36732285 Free article. Clinical Trial.
A 12-month, phase 2 study of once-weekly somatrogon vs. once-daily GH (Genotropin()) was initiated, after which participants could enroll into an open-label extension (OLE) evaluating the safety and efficacy of long-term somatrogon treatment. METHODS: There were five study …
A 12-month, phase 2 study of once-weekly somatrogon vs. once-daily GH (Genotropin()) was initiated, after which participants could enroll in …
Gonadotropin-releasing hormone analog therapies for children with central precocious puberty in the United States.
Popovic J, Geffner ME, Rogol AD, Silverman LA, Kaplowitz PB, Mauras N, Zeitler P, Eugster EA, Klein KO. Popovic J, et al. Among authors: mauras n. Front Pediatr. 2022 Oct 4;10:968485. doi: 10.3389/fped.2022.968485. eCollection 2022. Front Pediatr. 2022. PMID: 36268040 Free PMC article. Review.
One- and 3-month intramuscular (IM) leuprolide acetate (LA) have long-term safety and efficacy data and allow for flexible dosing. Six-month IM triptorelin pamoate offers a longer duration of treatment, but without long-term efficacy and outcome data. Six-month subc …
One- and 3-month intramuscular (IM) leuprolide acetate (LA) have long-term safety and efficacy data and allow for flexible dosing. Si …
A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes.
Reiss AL, Jo B, Arbelaez AM, Tsalikian E, Buckingham B, Weinzimer SA, Fox LA, Cato A, White NH, Tansey M, Aye T, Tamborlane W, Englert K, Lum J, Mazaika P, Foland-Ross L, Marzelli M, Mauras N; Diabetes Research in Children Network (DirecNet) Consortium. Reiss AL, et al. Among authors: mauras n. Nat Commun. 2022 Aug 30;13(1):4940. doi: 10.1038/s41467-022-32289-x. Nat Commun. 2022. PMID: 36042217 Free PMC article. Clinical Trial.
These results suggest that alterations to the developing brain in T1D might be preventable or reversible with rigorous glucose control. Long term research in this area is needed....
These results suggest that alterations to the developing brain in T1D might be preventable or reversible with rigorous glucose control. Long …
Can Short Bouts of Exercise ("Exercise Snacks") Improve Body Composition in Adolescents with Type 1 Diabetes? A Feasibility Study.
Hasan R, Perez-Santiago D, Churilla JR, Montes B, Hossain J, Mauras N, Darmaun D. Hasan R, et al. Among authors: mauras n. Horm Res Paediatr. 2019;92(4):245-253. doi: 10.1159/000505328. Epub 2020 Jan 31. Horm Res Paediatr. 2019. PMID: 32007996 Clinical Trial.
Although metabolic control was unchanged as a result of the intervention regardless of group, this was a short-term intervention, hence assessment of metabolic impact will require long-term study....
Although metabolic control was unchanged as a result of the intervention regardless of group, this was a short-term intervention, hen …
Impact of Early Diabetic Ketoacidosis on the Developing Brain.
Aye T, Mazaika PK, Mauras N, Marzelli MJ, Shen H, Hershey T, Cato A, Weinzimer SA, White NH, Tsalikian E, Jo B, Reiss AL; Diabetes Research in Children Network (DirecNet) Study Group. Aye T, et al. Among authors: mauras n. Diabetes Care. 2019 Mar;42(3):443-449. doi: 10.2337/dc18-1405. Epub 2018 Dec 20. Diabetes Care. 2019. PMID: 30573652 Free PMC article.
Further studies are needed to assess whether earlier diagnosis of type 1 diabetes and prevention of DKA may reduce the long-term effect of ketoacidosis on the developing brain....
Further studies are needed to assess whether earlier diagnosis of type 1 diabetes and prevention of DKA may reduce the long-term effe …
Glutamine and type 1 diabetes mellitus: is there a role in glycemic control?
Darmaun D, Torres-Santiago L, Mauras N. Darmaun D, et al. Among authors: mauras n. Curr Opin Clin Nutr Metab Care. 2019 Jan;22(1):91-95. doi: 10.1097/MCO.0000000000000530. Curr Opin Clin Nutr Metab Care. 2019. PMID: 30461450 Review.
SUMMARY: Further studies are warranted to determine whether the lowering effect of glutamine on blood glucose is sustained over time. If so, long-term randomized trials would be warranted to determine whether there is a role for glutamine as an adjunct dietary supplement t …
SUMMARY: Further studies are warranted to determine whether the lowering effect of glutamine on blood glucose is sustained over time. If so, …
Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome.
Mauras N, Torres-Santiago L, Santen R, Mericq V, Ross J, Colon-Otero G, Damaso L, Hossain J, Wang Q, Mesaros C, Blair IA. Mauras N, et al. Clin Endocrinol (Oxf). 2019 Jan;90(1):155-161. doi: 10.1111/cen.13869. Epub 2018 Oct 25. Clin Endocrinol (Oxf). 2019. PMID: 30281805 Clinical Trial.
OBJECTIVE: The established link between oestrogen and breast cancer occurs via both oestrogen receptor (ER)-mediated and non ER-mediated mechanisms. The term genotoxic estrogens describes mutagenic metabolites, including oestrogen catechols and quinones, which have been li …
OBJECTIVE: The established link between oestrogen and breast cancer occurs via both oestrogen receptor (ER)-mediated and non ER-mediated mec …
Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls.
Mauras N, Santen RJ, Colón-Otero G, Hossain J, Wang Q, Mesaros C, Blair IA. Mauras N, et al. J Clin Endocrinol Metab. 2015 Jun;100(6):2322-8. doi: 10.1210/jc.2015-1495. Epub 2015 Apr 9. J Clin Endocrinol Metab. 2015. PMID: 25856214 Free PMC article.
These data suggest that obesity is associated with an increased extraglandular estrogen production and metabolism before the onset of puberty in girls. Long-term epidemiological studies are needed to assess any potential increase in breast cancer risk....
These data suggest that obesity is associated with an increased extraglandular estrogen production and metabolism before the onset of pubert …
The development and utility of a novel scale that quantifies the glycemic progression toward type 1 diabetes over 6 months.
Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP; Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups. Sosenko JM, et al. Diabetes Care. 2015 May;38(5):940-2. doi: 10.2337/dc14-2787. Epub 2015 Mar 10. Diabetes Care. 2015. PMID: 25758770 Free PMC article.

PS6M values were higher in those with two or more autoantibodies, 30-0 min C-peptide values <2.00 ng/mL, or DPT-1 Risk Scores >7.00 (P < 0.001 for all). CONCLUSIONS: The PS6M is an indicator of short-term glycemic progression to T1D that could be a useful tool for

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PS6M values were higher in those with two or more autoantibodies, 30-0 min C-peptide values <2.00 ng/mL, or DPT-1 Risk Scores >7.00 (P …
36 results