Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

1 result

Filters applied: . Clear all
Page 1
Mutation-specific downregulation of CFTR2 variants by gating potentiators.
Avramescu RG, Kai Y, Xu H, Bidaud-Meynard A, Schnúr A, Frenkiel S, Matouk E, Veit G, Lukacs GL. Avramescu RG, et al. Among authors: matouk e. Hum Mol Genet. 2017 Dec 15;26(24):4873-4885. doi: 10.1093/hmg/ddx367. Hum Mol Genet. 2017. PMID: 29040544 Free PMC article.
Several mutants exhibit functional defects, correctable by gating potentiators. Long-term exposure (24 h) to the only available potentiator drug, VX-770, leads to the biochemical and functional downregulation of F508del-CFTR both in immortalized and primary human airway ce …
Several mutants exhibit functional defects, correctable by gating potentiators. Long-term exposure (24 h) to the only available poten …