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Danish Diabetes Birth Registry 2: a study protocol of a national prospective cohort study to monitor outcomes of pregnancies of women with pre-existing diabetes.
Knorr S, Aalders J, Overgaard M, Støvring H, Mathiesen ER, Damm P, Clausen TD, Bjerre-Christensen U, Andersen LLT, Vinter C, Kofoed-Enevoldsen A, Lauenborg J, Kampmann U, Fuglsang J, Ovesen PG, Christensen TT, Sørensen A, Ringholm L, Jensen DM. Knorr S, et al. Among authors: mathiesen er. BMJ Open. 2024 Apr 25;14(4):e082237. doi: 10.1136/bmjopen-2023-082237. BMJ Open. 2024. PMID: 38670616 Free article.
The rate of adverse outcomes in pregnancies affected by diabetes in Denmark is currently unknown, and there is a limited understanding of mechanisms contributing to this elevated risk. To address these gaps, the Danish Diabetes Birth Registry 2 (DDBR2) was established. The …
The rate of adverse outcomes in pregnancies affected by diabetes in Denmark is currently unknown, and there is a limited understanding of me …
Is the Biphasic Effect of Diabetes and Obesity on Fetal Growth a Risk Factor for Childhood Obesity?
van Poppel MNM, Damm P, Mathiesen ER, Ringholm L, Zhang C, Desoye G. van Poppel MNM, et al. Among authors: mathiesen er. Diabetes Care. 2023 Jun 1;46(6):1124-1131. doi: 10.2337/dc22-2409. Diabetes Care. 2023. PMID: 37220261 Review.
Similar to postnatal catch-up growth, this may confer a higher risk of obesity in later life. Potential long-term health consequences of early fetal growth reduction followed by in utero catch-up growth need to be explored....
Similar to postnatal catch-up growth, this may confer a higher risk of obesity in later life. Potential long-term health consequences …
Secular trend for increasing birthweight in offspring of pregnant women with type 1 diabetes: is improved placentation the reason?
Desoye G, Ringholm L, Damm P, Mathiesen ER, van Poppel MNM. Desoye G, et al. Among authors: mathiesen er. Diabetologia. 2023 Jan;66(1):33-43. doi: 10.1007/s00125-022-05820-4. Epub 2022 Oct 26. Diabetologia. 2023. PMID: 36287249 Free PMC article. Review.
While, previously, fetal undergrowth was not uncommon in these women, with improved maternal glycaemic control we now see an increased prevalence of fetal overgrowth. Besides short-term implications, offspring of women with type 1 diabetes are more likely to become obese a …
While, previously, fetal undergrowth was not uncommon in these women, with improved maternal glycaemic control we now see an increased preva …
Potentially modifiable risk factors of preterm delivery in women with type 1 and type 2 diabetes.
Søholm JC, Vestgaard M, Ásbjörnsdóttir B, Do NC, Pedersen BW, Storgaard L, Nielsen BB, Ringholm L, Damm P, Mathiesen ER. Søholm JC, et al. Among authors: mathiesen er. Diabetologia. 2021 Sep;64(9):1939-1948. doi: 10.1007/s00125-021-05482-8. Epub 2021 Jun 19. Diabetologia. 2021. PMID: 34146144

Women delivering preterm were characterised by a higher prevalence of pre-existing kidney involvement (microalbuminuria or diabetic nephropathy) (16% vs 3%, p = 0.002), preeclampsia (26% vs 5%, p < 0.001), higher positive ultrasound estimated fetal weight deviation at 27 gesta

Women delivering preterm were characterised by a higher prevalence of pre-existing kidney involvement (microalbuminuria or diabetic nephropa …
Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial.
Nordklint AK, Almdal TP, Vestergaard P, Lundby-Christensen L, Boesgaard TW, Breum L, Gade-Rasmussen B, Sneppen SB, Gluud C, Hemmingsen B, Perrild H, Madsbad S, Mathiesen ER, Tarnow L, Thorsteinsson B, Vestergaard H, Lund SS, Eiken P. Nordklint AK, et al. Among authors: mathiesen er. Osteoporos Int. 2021 Sep;32(9):1837-1848. doi: 10.1007/s00198-021-05870-1. Epub 2021 Feb 16. Osteoporos Int. 2021. PMID: 33594488 Clinical Trial.
INTRODUCTION: Glucose-lowering medications affect body composition. We assessed the long-term effects of metformin compared with placebo on whole body bone and body composition measures in patients with type 2 diabetes mellitus. ...
INTRODUCTION: Glucose-lowering medications affect body composition. We assessed the long-term effects of metformin compared with plac …
Gestational diabetes mellitus.
McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. McIntyre HD, et al. Among authors: mathiesen er. Nat Rev Dis Primers. 2019 Jul 11;5(1):47. doi: 10.1038/s41572-019-0098-8. Nat Rev Dis Primers. 2019. PMID: 31296866 Review.
Hyperglycaemia that develops during pregnancy and resolves after birth has been recognized for over 50 years, but uniform worldwide consensus is lacking about threshold hyperglycaemic levels that merit a diagnosis of 'gestational diabetes mellitus' (GDM) and thus treatment …
Hyperglycaemia that develops during pregnancy and resolves after birth has been recognized for over 50 years, but uniform worldwide c …
The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial.
Nordklint AK, Almdal TP, Vestergaard P, Lundby-Christensen L, Boesgaard TW, Breum L, Gade-Rasmussen B, Sneppen SB, Gluud C, Hemmingsen B, Jensen T, Krarup T, Madsbad S, Mathiesen ER, Perrild H, Tarnow L, Thorsteinsson B, Vestergaard H, Lund SS, Eiken P. Nordklint AK, et al. Among authors: mathiesen er. Osteoporos Int. 2018 Nov;29(11):2517-2526. doi: 10.1007/s00198-018-4637-z. Epub 2018 Jul 19. Osteoporos Int. 2018. PMID: 30027438 Clinical Trial.
Some antihyperglycemic medications have been found to affect bone metabolism. We assessed the long-term effects of metformin compared with placebo on bone mineral density (BMD) and trabecular bone score (TBS) in patients with type 2 diabetes. ...Some antihyperglycemic medi …
Some antihyperglycemic medications have been found to affect bone metabolism. We assessed the long-term effects of metformin compared …
Diabetes, myometrium, and mitochondria in pregnant women at term.
Gam CMBF, Mortensen OH, Larsen LH, Poulsen SS, Qvortrup K, Mathiesen ER, Damm P, Quistorff B. Gam CMBF, et al. Among authors: mathiesen er. Acta Diabetol. 2018 Oct;55(10):999-1010. doi: 10.1007/s00592-018-1171-6. Epub 2018 Jun 21. Acta Diabetol. 2018. PMID: 29931421
AIMS: Poor myometrial contractility has been demonstrated in women at term with diabetes and decreased muscular mitochondrial content and/or function has been extensively implicated in the progression of type 2 diabetes. ...CONCLUSION: No indication of decreased mitochondr …
AIMS: Poor myometrial contractility has been demonstrated in women at term with diabetes and decreased muscular mitochondrial content …
Impact of type 1 diabetes on maternal long-term risk of hospitalisation and mortality: a nationwide combined clinical and register-based cohort study (The EPICOM study).
Knorr S, Juul S, Bytoft B, Lohse Z, Clausen TD, Jensen RB, Damm P, Beck-Nielsen H, Mathiesen ER, Jensen DM, Gravholt CH. Knorr S, et al. Among authors: mathiesen er. Diabetologia. 2018 May;61(5):1071-1080. doi: 10.1007/s00125-018-4575-5. Epub 2018 Feb 24. Diabetologia. 2018. PMID: 29478097
AIMS/HYPOTHESIS: The aims of this study were to examine long-term mortality and morbidity rates in mothers with type 1 diabetes, both overall and according to the level of albuminuria prior to pregnancy, the presence of hypertension, pre-eclampsia and periconceptional HbA( …
AIMS/HYPOTHESIS: The aims of this study were to examine long-term mortality and morbidity rates in mothers with type 1 diabetes, both …
Unchanged mitochondrial phenotype, but accumulation of lipids in the myometrium in obese pregnant women.
Gam CMBF, Larsen LH, Mortensen OH, Engelbrechtsen L, Poulsen SS, Qvortrup K, Mathiesen ER, Damm P, Quistorff B. Gam CMBF, et al. Among authors: mathiesen er. J Physiol. 2017 Dec 1;595(23):7109-7122. doi: 10.1113/JP274838. Epub 2017 Nov 9. J Physiol. 2017. PMID: 29119568 Free PMC article.
Data did not support reduced myometrial mitochondrial capacity or quantity in the myometrium at term in obese women, but a reduced myocyte density with increased triglyceride content was demonstrated, which could lead to poorer uterine contractility. ...In the present stud …
Data did not support reduced myometrial mitochondrial capacity or quantity in the myometrium at term in obese women, but a reduced my …
39 results