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Outcomes of minority patients with very severe hypertension (>220/>120 mmHg).
Preston RA, Arciniegas R, DeGraff S, Materson BJ, Bernstein J, Afshartous D. Preston RA, et al. Among authors: materson bj. J Hypertens. 2019 Feb;37(2):415-425. doi: 10.1097/HJH.0000000000001906. J Hypertens. 2019. PMID: 30520848
Our findings indicate a need to develop effective management strategies to lower blood pressure safely and to prevent long-term consequences. Our findings may apply to other hospitals caring for ethnic minority populations....
Our findings indicate a need to develop effective management strategies to lower blood pressure safely and to prevent long-term conse …
Combination therapy in hypertension.
Gradman AH, Basile JN, Carter BL, Bakris GL; American Society of Hypertension Writing Group. Gradman AH, et al. J Clin Hypertens (Greenwich). 2011 Mar;13(3):146-54. doi: 10.1111/j.1751-7176.2010.00397.x. Epub 2010 Dec 10. J Clin Hypertens (Greenwich). 2011. PMID: 21366845 Free PMC article.
Although the choice of initial drug therapy exerts some effect on long-term outcomes, it is evident that BP reduction per se is the primary determinant of CV risk reduction. ...
Although the choice of initial drug therapy exerts some effect on long-term outcomes, it is evident that BP reduction per se is the p …
Combination therapy in hypertension.
Gradman AH, Basile JN, Carter BL, Bakris GL, Materson BJ, Black HR, Izzo JL Jr, Oparil S, Weber MA. Gradman AH, et al. Among authors: materson bj. J Am Soc Hypertens. 2010 Mar-Apr;4(2):90-8. doi: 10.1016/j.jash.2010.03.001. J Am Soc Hypertens. 2010. PMID: 20400053
Although the choice of initial drug therapy exerts some effect on long-term outcomes, it is evident that BP reduction per se is the primary determinant of CV risk reduction. ...
Although the choice of initial drug therapy exerts some effect on long-term outcomes, it is evident that BP reduction per se is the p …
Historical perspective of low- vs. high-dose diuretics.
Materson BJ. Materson BJ. J Am Soc Hypertens. 2007 Nov-Dec;1(6):373-80. doi: 10.1016/j.jash.2007.06.007. J Am Soc Hypertens. 2007. PMID: 20409870
Initially, high doses of diuretics were employed at least in part because of the misconception that substantial natriuresis was required for their antihypertensive effect. As the long-term vasodilating effects of the thiazides became appreciated, it was possible to separat …
Initially, high doses of diuretics were employed at least in part because of the misconception that substantial natriuresis was required for …
Response to six classes of antihypertensive medications by body mass index in a randomized controlled trial.
Materson BJ, Williams DW, Reda DJ, Cushman WC; Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Materson BJ, et al. J Clin Hypertens (Greenwich). 2003 May-Jun;5(3):197-201. doi: 10.1111/j.1524-6175.2003.02029.x. J Clin Hypertens (Greenwich). 2003. PMID: 12826782 Free PMC article. Clinical Trial.
Obesity has been said to cause resistance to antihypertensive medications. We compared short-term and 1-year blood pressure response by BMI category and weight change with hydrochlorothiazide, atenolol, diltiazem-SR, captopril, clonidine, prazosin, or placebo in 1292 male …
Obesity has been said to cause resistance to antihypertensive medications. We compared short-term and 1-year blood pressure response …
Regional and racial differences in response to antihypertensive medication use in a randomized controlled trial of men with hypertension in the United States. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Cushman WC, Reda DJ, Perry HM, Williams D, Abdellatif M, Materson BJ. Cushman WC, et al. Among authors: materson bj. Arch Intern Med. 2000 Mar 27;160(6):825-31. doi: 10.1001/archinte.160.6.825. Arch Intern Med. 2000. PMID: 10737282 Clinical Trial.
We compared the response to antihypertensive medication use in patients from different US regions. METHODS: The short-term and 1-year efficacy of the antihypertensive medications hydrochlorothiazide, atenolol, diltiazem hydrochloride (sustained release), captopril, prazosi …
We compared the response to antihypertensive medication use in patients from different US regions. METHODS: The short-term and 1-year …
Clinical presentation and management of patients with uncontrolled, severe hypertension: results from a public teaching hospital.
Preston RA, Baltodano NM, Cienki J, Materson BJ. Preston RA, et al. Among authors: materson bj. J Hum Hypertens. 1999 Apr;13(4):249-55. doi: 10.1038/sj.jhh.1000796. J Hum Hypertens. 1999. PMID: 10333343
Forty-two patients (46%) had the SBP reduced to less than 160 mm Hg, and 46 patients (50%) the DBP to less than 100 mm Hg. Long-term management and follow-up were suboptimal. Of 74 patients discharged from the emergency room, 22 patients (30%) returned because of uncontrol …
Forty-two patients (46%) had the SBP reduced to less than 160 mm Hg, and 46 patients (50%) the DBP to less than 100 mm Hg. Long-term
Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Lakshman MR, Reda DJ, Materson BJ, Cushman WC, Freis ED. Lakshman MR, et al. Among authors: materson bj. Arch Intern Med. 1999 Mar 22;159(6):551-8. doi: 10.1001/archinte.159.6.551. Arch Intern Med. 1999. PMID: 10090111 Clinical Trial.
CONCLUSIONS: None of these 6 antihypertensive drugs has any long-term adverse effects on PLPPs and, therefore, may be safely prescribed. Previously reported short-term adverse effects from using hydrochlorothiazide are limited to nonresponders....
CONCLUSIONS: None of these 6 antihypertensive drugs has any long-term adverse effects on PLPPs and, therefore, may be safely prescrib …
Will angiotensin converting enzyme genotype, receptor mutation identification, and other miracles of molecular biology permit reduction of NNT?
Materson BJ. Materson BJ. Am J Hypertens. 1998 Aug;11(8 Pt 2):138S-142S. doi: 10.1016/s0895-7061(98)00105-8. Am J Hypertens. 1998. PMID: 9717855 Review.
Stage 1-2 hypertension has a low morbidity and mortality; short-term benefits of treatment are harder to document. Managed care organizations know that members have a high turnover rate, so they are less interested in costly mass treatment to prevent a few future events. . …
Stage 1-2 hypertension has a low morbidity and mortality; short-term benefits of treatment are harder to document. Managed care organ …