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Disease progression modelling of Alzheimer's disease using probabilistic principal components analysis.
Saint-Jalmes M, Fedyashov V, Beck D, Baldwin T, Faux NG, Bourgeat P, Fripp J, Masters CL, Goudey B; Alzheimer’s Disease Neuroimaging Initiative. Saint-Jalmes M, et al. Among authors: masters cl. Neuroimage. 2023 Sep;278:120279. doi: 10.1016/j.neuroimage.2023.120279. Epub 2023 Jul 15. Neuroimage. 2023. PMID: 37454702 Free article.
In addition to cross-sectional insights, we can model the latent variable as an individual progression score by repeating estimations at follow-up examinations and refining long-term estimates as more data is gathered, which would be ideal in a clinical setting. ...
In addition to cross-sectional insights, we can model the latent variable as an individual progression score by repeating estimations at fol …
Alzheimer's disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals.
Pettigrew C, Nazarovs J, Soldan A, Singh V, Wang J, Hohman T, Dumitrescu L, Libby J, Kunkle B, Gross AL, Johnson S, Lu Q, Engelman C, Masters CL, Maruff P, Laws SM, Morris JC, Hassenstab J, Cruchaga C, Resnick SM, Kitner-Triolo MH, An Y, Albert M. Pettigrew C, et al. Among authors: masters cl. Alzheimers Res Ther. 2023 Mar 28;15(1):66. doi: 10.1186/s13195-023-01206-9. Alzheimers Res Ther. 2023. PMID: 36978190 Free PMC article.
This study examined whether a CR index score modifies the relationship between AD genetic risk factors and long-term cognitive trajectories in a large sample of individuals with normal cognition. ...
This study examined whether a CR index score modifies the relationship between AD genetic risk factors and long-term cognitive trajec …
Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline.
Ossenkoppele R, Pichet Binette A, Groot C, Smith R, Strandberg O, Palmqvist S, Stomrud E, Tideman P, Ohlsson T, Jögi J, Johnson K, Sperling R, Dore V, Masters CL, Rowe C, Visser D, van Berckel BNM, van der Flier WM, Baker S, Jagust WJ, Wiste HJ, Petersen RC, Jack CR Jr, Hansson O. Ossenkoppele R, et al. Among authors: masters cl. Nat Med. 2022 Nov;28(11):2381-2387. doi: 10.1038/s41591-022-02049-x. Epub 2022 Nov 10. Nat Med. 2022. PMID: 36357681 Free PMC article.
In summary, evidence of advanced Alzheimer's disease pathological changes provided by a combination of abnormal amyloid and tau PET examinations is strongly associated with short-term (that is, 3-5 years) cognitive decline in cognitively unimpaired individuals and is there …
In summary, evidence of advanced Alzheimer's disease pathological changes provided by a combination of abnormal amyloid and tau PET examinat …
Nationally Informed Recommendations on Approaching the Detection, Assessment, and Management of Mild Cognitive Impairment.
Woodward M, Brodaty H, McCabe M, Masters CL, Naismith SL, Morris P, Rowe CC, Walker P, Yates M. Woodward M, et al. Among authors: masters cl. J Alzheimers Dis. 2022;89(3):803-809. doi: 10.3233/JAD-220288. J Alzheimers Dis. 2022. PMID: 35964184 Free PMC article.
Specifically, these relate to detection and diagnosis; sharing the diagnosis, monitoring, and follow up; practical interventions to potentially delay progression; and personalizing care-planning, engagement, and patient motivation for the long term....
Specifically, these relate to detection and diagnosis; sharing the diagnosis, monitoring, and follow up; practical interventions to potentia …
Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment.
Strikwerda-Brown C, Hobbs DA, Gonneaud J, St-Onge F, Binette AP, Ozlen H, Provost K, Soucy JP, Buckley RF, Benzinger TLS, Morris JC, Villemagne VL, Doré V, Sperling RA, Johnson KA, Rowe CC, Gordon BA, Poirier J, Breitner JCS, Villeneuve S; PREVENT-AD, HABS, and AIBL Research Groups. Strikwerda-Brown C, et al. JAMA Neurol. 2022 Oct 1;79(10):975-985. doi: 10.1001/jamaneurol.2022.2379. JAMA Neurol. 2022. PMID: 35907254 Free PMC article.
OBJECTIVE: To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-term risk of developing symptomatic AD. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal cohort study used data from 4 indepe …
OBJECTIVE: To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at n …
Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis.
Chin KS, Yassi N, Churilov L, Masters CL, Watson R. Chin KS, et al. Among authors: masters cl. Parkinsonism Relat Disord. 2020 Nov;80:184-193. doi: 10.1016/j.parkreldis.2020.09.030. Epub 2020 Sep 23. Parkinsonism Relat Disord. 2020. PMID: 33260030
METHODS: We searched the major electronic databases using the search term: ("dementia with Lewy bodies" OR "diffuse Lewy body disease" OR "Lewy body variant of Alzheimer's disease") AND ("tau protein" OR "tauopathy" OR "neurofibrillary tangle"), for relevant studies which …
METHODS: We searched the major electronic databases using the search term: ("dementia with Lewy bodies" OR "diffuse Lewy body disease …
Longitudinal evaluation of the natural history of amyloid-β in plasma and brain.
Burnham SC, Fandos N, Fowler C, Pérez-Grijalba V, Dore V, Doecke JD, Shishegar R, Cox T, Fripp J, Rowe C, Sarasa M, Masters CL, Pesini P, Villemagne VL. Burnham SC, et al. Among authors: masters cl. Brain Commun. 2020 Apr 14;2(1):fcaa041. doi: 10.1093/braincomms/fcaa041. eCollection 2020. Brain Commun. 2020. PMID: 32954297 Free PMC article.
We applied our method for obtaining natural history trajectories from short term data to measures of total protein amyloid-beta 42/40 plasma ratios and PET amyloid-beta. ...
We applied our method for obtaining natural history trajectories from short term data to measures of total protein amyloid-beta 42/40 …
Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN).
Aschenbrenner AJ, James BD, McDade E, Wang G, Lim YY, Benzinger TLS, Cruchaga C, Goate A, Xiong C, Perrin R, Buckles V, Allegri R, Berman SB, Chhatwal JP, Fagan A, Farlow M, O'Connor A, Ghetti B, Graff-Radford N, Goldman J, Gräber S, Karch CM, Lee JH, Levin J, Martins RN, Masters C, Mori H, Noble J, Salloway S, Schofield P, Morris JC, Bateman RJ, Hassenstab J; Dominantly Inherited Alzheimer Network. Aschenbrenner AJ, et al. Among authors: masters c. Alzheimers Dement. 2020 Jan;16(1):219-228. doi: 10.1002/alz.12010. Alzheimers Dement. 2020. PMID: 31914221 Free PMC article.
DISCUSSION: Knowledge of mutation status does not affect rates of change on any measured outcome. Learning of status mid-study may confer short-term changes in cognitive functioning, or changes in cognition may influence the determination of mutation status....
DISCUSSION: Knowledge of mutation status does not affect rates of change on any measured outcome. Learning of status mid-study may confer sh …
Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial.
Venkatraman VK, Sanderson A, Cox KL, Ellis KA, Steward C, Phal PM, Gorelik A, Sharman MJ, Villemagne VL, Lai M, Cyarto EV, Merkel B, Ames D, Szoeke C, Rowe CC, Masters CL, Lautenschlager NT, Desmond PM. Venkatraman VK, et al. Among authors: masters cl. Neurobiol Aging. 2020 May;89:132-141. doi: 10.1016/j.neurobiolaging.2019.02.030. Epub 2019 May 27. Neurobiol Aging. 2020. PMID: 31324405 Clinical Trial.
Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. ...In this cohort of subjective memory compl …
Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progress …
32 results