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A Multi-Modal Approach to Islet and Pancreas Transplantation With Calcineurin-Sparing Immunosuppression Maintains Long-Term Insulin Independence in Patients With Type I Diabetes.
Wisel SA, Posselt AM, Szot GL, Nunez M, Santos-Parker K, Gardner JM, Worner G, Roll GR, Syed S, Kelly Y, Ward C, Tavakol M, Johnson K, Masharani U, Stock PG. Wisel SA, et al. Among authors: masharani u. Transpl Int. 2023 Jun 8;36:11367. doi: 10.3389/ti.2023.11367. eCollection 2023. Transpl Int. 2023. PMID: 37359825 Free PMC article.
Long-term success in beta-cell replacement remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta-cells and renal function. ...In our series, repeat islet transplant is ineffective at maintaining long-term insulin independence. PAI results in d …
Long-term success in beta-cell replacement remains limited by the toxic effects of calcineurin inhibitors (CNI) on beta-cells and ren …
Estimating Long-Term Health Utility Scores and Expenditures for Cardiovascular Disease From the Medical Expenditure Panel Survey.
Morey JR, Jiang S, Klein S, Max W, Masharani U, Fleischmann KE, Hunink MGM, Ferket BS. Morey JR, et al. Among authors: masharani u. Circ Cardiovasc Qual Outcomes. 2021 Apr;14(4):e006769. doi: 10.1161/CIRCOUTCOMES.120.006769. Epub 2021 Mar 25. Circ Cardiovasc Qual Outcomes. 2021. PMID: 33761758
BACKGROUND: Long-term health utility scores and costs used in cost-effectiveness analyses of cardiovascular disease prevention and management can be inconsistent, outdated, or invalid for the diverse population of the United States. Our aim was to develop a user friendly, …
BACKGROUND: Long-term health utility scores and costs used in cost-effectiveness analyses of cardiovascular disease prevention and ma …
Economic costs of implementing group interventions to reduce diabetes distress in adults with type 1 diabetes mellitus in the T1-REDEEM trial.
Shumway M, Fisher L, Hessler D, Bowyer V, Polonsky WH, Masharani U. Shumway M, et al. Among authors: masharani u. J Diabetes Complications. 2019 Nov;33(11):107416. doi: 10.1016/j.jdiacomp.2019.107416. Epub 2019 Aug 15. J Diabetes Complications. 2019. PMID: 31473079 Free PMC article. Clinical Trial.
These inventions and their costs merit further attention because reducing diabetes distress may impact long term T1DM outcomes. CLINICAL TRIALS REGISTRATION: ClinicalTrials.govNCT02175732....
These inventions and their costs merit further attention because reducing diabetes distress may impact long term T1DM outcomes. CLINI …
A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes.
Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, Posselt AM. Moassesfar S, et al. Among authors: masharani u. Am J Transplant. 2016 Feb;16(2):518-26. doi: 10.1111/ajt.13536. Epub 2015 Nov 23. Am J Transplant. 2016. PMID: 26595767 Free PMC article.
We conclude that with advances in islet isolation and posttransplant management, ITA can produce outcomes similar to PTA and represents a clinically viable option to achieve long-term insulin independence in selected patients with T1D....
We conclude that with advances in islet isolation and posttransplant management, ITA can produce outcomes similar to PTA and represents a cl …
Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes.
Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, Nolte Kennedy M, Frassetto L. Masharani U, et al. Eur J Clin Nutr. 2015 Aug;69(8):944-8. doi: 10.1038/ejcn.2015.39. Epub 2015 Apr 1. Eur J Clin Nutr. 2015. PMID: 25828624 Clinical Trial.
Also, on the Paleo diet, the most insulin-resistant subjects had a significant improvement in insulin sensitivity (r = 0.40, P = 0.02), but no such effect was seen in the most insulin-resistant subjects on the ADA diet (r = 0.39, P = 0.3). CONCLUSIONS: Even short-term cons …
Also, on the Paleo diet, the most insulin-resistant subjects had a significant improvement in insulin sensitivity (r = 0.40, P = 0.02), but …
Prediabetic living kidney donors have preserved kidney function at 10 years after donation.
Chandran S, Masharani U, Webber AB, Wojciechowski DM. Chandran S, et al. Among authors: masharani u. Transplantation. 2014 Apr 15;97(7):748-54. doi: 10.1097/01.TP.0000438625.91095.8b. Transplantation. 2014. PMID: 24342975
CONCLUSION: Carefully screened prediabetic living kidney donors often revert to normal fasting glucose and do not seem to have a significantly increased risk of impaired kidney function in the short term....
CONCLUSION: Carefully screened prediabetic living kidney donors often revert to normal fasting glucose and do not seem to have a significant …
Prospective safety surveillance of GH-deficient adults: comparison of GH-treated vs untreated patients.
Hartman ML, Xu R, Crowe BJ, Robison LL, Erfurth EM, Kleinberg DL, Zimmermann AG, Woodmansee WW, Cutler GB Jr, Chipman JJ, Melmed S; International HypoCCS Advisory Board. Hartman ML, et al. J Clin Endocrinol Metab. 2013 Mar;98(3):980-8. doi: 10.1210/jc.2012-2684. Epub 2013 Jan 23. J Clin Endocrinol Metab. 2013. PMID: 23345098 Free PMC article.
CONCLUSIONS: In GH-deficient adults, there was no evidence for a GH treatment effect on death, cancer, intracranial tumor recurrence, diabetes, or cardiovascular events, although the follow-up period was of insufficient duration to be conclusive for these long-term events. …
CONCLUSIONS: In GH-deficient adults, there was no evidence for a GH treatment effect on death, cancer, intracranial tumor recurrence, diabet …
Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.
Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG. Posselt AM, et al. Among authors: masharani u. Transplantation. 2010 Dec 27;90(12):1595-601. doi: 10.1097/TP.0b013e3181fe1377. Transplantation. 2010. PMID: 20978464 Free PMC article.
BACKGROUND: The applicability of islet transplantation as treatment for type 1 diabetes is limited by long-term graft dysfunction, immunosuppressive drug toxicity, need for multiple donors, and increased risk of allosensitization. We describe two immunosuppressive regimens …
BACKGROUND: The applicability of islet transplantation as treatment for type 1 diabetes is limited by long-term graft dysfunction, im …
Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.
Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG. Posselt AM, et al. Among authors: masharani u. Am J Transplant. 2010 Aug;10(8):1870-80. doi: 10.1111/j.1600-6143.2010.03073.x. Am J Transplant. 2010. PMID: 20659093 Free PMC article.
We describe a novel immunosuppressive regimen using the antileukocyte functional antigen-1 antibody efalizumab which permits long-term islet allograft survival while reducing the need for corticosteroids and calcineurin inhibitors (CNI). ...Such an approach may minimize re …
We describe a novel immunosuppressive regimen using the antileukocyte functional antigen-1 antibody efalizumab which permits long-term …
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