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The physiological underpinnings of life-saving respiratory support.
Telias I, Brochard LJ, Gattarello S, Wunsch H, Junhasavasdikul D, Bosma KJ, Camporota L, Brodie D, Marini JJ, Slutsky AS, Gattinoni L. Telias I, et al. Among authors: marini jj. Intensive Care Med. 2022 Oct;48(10):1274-1286. doi: 10.1007/s00134-022-06749-3. Epub 2022 Jun 12. Intensive Care Med. 2022. PMID: 35690953 Free PMC article. Review.
., immobilization, sleep disruption) can have devastating long-term effects. Increasing awareness and understanding of these mechanisms of injury has led to a change in the philosophy of care with a shift from aiming to normalize gases toward minimizing harm. ...
., immobilization, sleep disruption) can have devastating long-term effects. Increasing awareness and understanding of these mechanis …
The future of mechanical ventilation: lessons from the present and the past.
Gattinoni L, Marini JJ, Collino F, Maiolo G, Rapetti F, Tonetti T, Vasques F, Quintel M. Gattinoni L, et al. Among authors: marini jj. Crit Care. 2017 Jul 12;21(1):183. doi: 10.1186/s13054-017-1750-x. Crit Care. 2017. PMID: 28701178 Free PMC article. Review.
The changes of transpulmonary pressure and pleural pressure resulting from a given applied driving pressure depend on the relative elastances of the lung and chest wall. The term 'volutrauma' should refer to excessive strain, while 'barotrauma' should refer to excessive st …
The changes of transpulmonary pressure and pleural pressure resulting from a given applied driving pressure depend on the relative elastance …
Practical assessment of risk of VILI from ventilating power: a conceptual model.
Marini JJ, Thornton LT, Rocco PRM, Gattinoni L, Crooke PS. Marini JJ, et al. Crit Care. 2023 Apr 20;27(1):157. doi: 10.1186/s13054-023-04406-9. Crit Care. 2023. PMID: 37081517 Free PMC article. Review.
For this purpose, driving pressure (DP) and end-inspiratory static 'plateau' pressure ([Formula: see text]) of the tidal cycle are unquestionably useful but lack key information relating to associated volume changes and cumulative strain. 'Mechanical power', a clinical term …
For this purpose, driving pressure (DP) and end-inspiratory static 'plateau' pressure ([Formula: see text]) of the tidal cycle are unquestio …
Excellence in Intensive Care Medicine.
Sprung CL, Cohen R, Marini JJ. Sprung CL, et al. Among authors: marini jj. Crit Care Med. 2016 Jan;44(1):202-6. doi: 10.1097/CCM.0000000000001435. Crit Care Med. 2016. PMID: 26584193 Review.
STUDY SELECTION: Publications or studies of excellence, role models, compassion, commitment, dedication, and passion. Two reviewers evaluated each term. DATA EXTRACTION: Publications or studies were abstracted independently and in duplicate. ...
STUDY SELECTION: Publications or studies of excellence, role models, compassion, commitment, dedication, and passion. Two reviewers evaluate …
Respiratory support in patients with acute respiratory distress syndrome: an expert opinion.
Chiumello D, Brochard L, Marini JJ, Slutsky AS, Mancebo J, Ranieri VM, Thompson BT, Papazian L, Schultz MJ, Amato M, Gattinoni L, Mercat A, Pesenti A, Talmor D, Vincent JL. Chiumello D, et al. Among authors: marini jj. Crit Care. 2017 Sep 12;21(1):240. doi: 10.1186/s13054-017-1820-0. Crit Care. 2017. PMID: 28899408 Free PMC article. Review.
Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality rates of around 30-45% and considerable long-term morbidity. Respiratory support in these patients must be optimized to ensure adequ …
Acute respiratory distress syndrome (ARDS) is a common condition in intensive care unit patients and remains a major concern, with mortality …
Developmental changes in the utilization of citrulline by neonatal pigs.
Mohammad MA, Didelija IC, Wang X, Stoll B, Burrin DG, Marini JC. Mohammad MA, et al. Among authors: marini jc. Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F175-F182. doi: 10.1152/ajprenal.00469.2019. Epub 2019 Nov 25. Am J Physiol Renal Physiol. 2020. PMID: 31760772 Free PMC article.
The tracer was given in substrate amounts to also test the ability of neonatal pigs to use exogenous citrulline. Preterm and term pigs at birth had lower ASS1 and ASL expression than older animals, which was reflected in the longer half-life of citrulline in the neo …
The tracer was given in substrate amounts to also test the ability of neonatal pigs to use exogenous citrulline. Preterm and term pig …
Historical control histopathology data from amphibian metamorphosis assays and fathead minnow fish short term reproductive assays: A tool for data interpretation.
Wolf JC, Green JW, Mingo V, Marini JP, Schneider SZ, Fort DJ, Wheeler JR. Wolf JC, et al. Among authors: marini jp. Aquat Toxicol. 2024 Feb;267:106811. doi: 10.1016/j.aquatox.2023.106811. Epub 2023 Dec 20. Aquat Toxicol. 2024. PMID: 38159458 Free article. Review.
The Amphibian Metamorphosis Assay (AMA) is used to determine if a tested chemical has potential to impact the hypothalamic-pituitary-thyroid (HPT) axis of Xenopus laevis tadpoles, while the Fish Short Term Reproduction Assay (FSTRA) assesses potential effects on the hypoth …
The Amphibian Metamorphosis Assay (AMA) is used to determine if a tested chemical has potential to impact the hypothalamic-pituitary-thyroid …
Ventilation patterns influence airway secretion movement.
Volpe MS, Adams AB, Amato MB, Marini JJ. Volpe MS, et al. Among authors: marini jj. Respir Care. 2008 Oct;53(10):1287-94. Respir Care. 2008. PMID: 18811989 Free article.
Treating or avoiding secretion retention with mucus thinning, patient-positioning, airway suctioning, or chest or airway vibration or percussion may provide short-term benefit. METHODS: In a series of laboratory experiments with a test-lung system we examined the role of v …
Treating or avoiding secretion retention with mucus thinning, patient-positioning, airway suctioning, or chest or airway vibration or percus …
Modeling age-dependent developmental changes in the expression of genes involved in citrulline synthesis using pig enteroids.
Mohammad MA, Didelija IC, Stoll B, Burrin DG, Marini JC. Mohammad MA, et al. Among authors: marini jc. Physiol Rep. 2020 Nov;8(21):e14565. doi: 10.14814/phy2.14565. Physiol Rep. 2020. PMID: 33181004 Free PMC article.
OBJECTIVE: The present study tested the hypothesis that enteroids recapitulate the developmental changes observed in vivo regarding citrulline production in pigs ("developmental memory"). METHODS: Preterm (10- and 5-d preterm) and term pigs at birth, together with 7 …
OBJECTIVE: The present study tested the hypothesis that enteroids recapitulate the developmental changes observed in vivo regarding citrulli …
Phenylbutyrate therapy for maple syrup urine disease.
Brunetti-Pierri N, Lanpher B, Erez A, Ananieva EA, Islam M, Marini JC, Sun Q, Yu C, Hegde M, Li J, Wynn RM, Chuang DT, Hutson S, Lee B. Brunetti-Pierri N, et al. Among authors: marini jc. Hum Mol Genet. 2011 Feb 15;20(4):631-40. doi: 10.1093/hmg/ddq507. Epub 2010 Nov 23. Hum Mol Genet. 2011. PMID: 21098507 Free PMC article. Clinical Trial.
Phenylbutyrate treatment may be a valuable treatment for reducing the plasma levels of neurotoxic BCAA and their corresponding BCKA in a subset of MSUD patients and studies of its long-term efficacy are indicated....
Phenylbutyrate treatment may be a valuable treatment for reducing the plasma levels of neurotoxic BCAA and their corresponding BCKA in a sub …
29 results