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1975 1
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2017 5
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33 results

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Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant.
Lyke KE, Atmar RL, Islas CD, Posavad CM, Szydlo D, Paul Chourdhury R, Deming ME, Eaton A, Jackson LA, Branche AR, El Sahly HM, Rostad CA, Martin JM, Johnston C, Rupp RE, Mulligan MJ, Brady RC, Frenck RW Jr, Bäcker M, Kottkamp AC, Babu TM, Rajakumar K, Edupuganti S, Dobrzynski D, Coler RN, Archer JI, Crandon S, Zemanek JA, Brown ER, Neuzil KM, Stephens DS, Post DJ, Nayak SU, Suthar MS, Roberts PC, Beigel JH, Montefiori DC; DMID 21-0012 Study Group. Lyke KE, et al. Cell Rep Med. 2022 Jul 19;3(7):100679. doi: 10.1016/j.xcrm.2022.100679. Epub 2022 Jun 20. Cell Rep Med. 2022. PMID: 35798000 Free PMC article. Clinical Trial.
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost to generate protective immunity. We assess the magnitude and short-term durability of neutraliz …
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutr …
Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants.
Lyke KE, Atmar RL, Dominguez Islas C, Posavad CM, Deming ME, Branche AR, Johnston C, El Sahly HM, Edupuganti S, Mulligan MJ, Jackson LA, Rupp RE, Rostad CA, Coler RN, Bäcker M, Kottkamp AC, Babu TM, Dobrzynski D, Martin JM, Brady RC, Frenck RW Jr, Rajakumar K, Kotloff K, Rouphael N, Szydlo D, PaulChoudhury R, Archer JI, Crandon S, Ingersoll B, Eaton A, Brown ER, McElrath MJ, Neuzil KM, Stephens DS, Post DJ, Lin BC, Serebryannyy L, Beigel JH, Montefiori DC, Roberts PC; DMID 21-0012 Study Group. Lyke KE, et al. NPJ Vaccines. 2023 Jul 11;8(1):98. doi: 10.1038/s41541-023-00693-z. NPJ Vaccines. 2023. PMID: 37433788 Free PMC article.
As part of a multicenter study evaluating homologous and heterologous COVID-19 booster vaccines, we assessed the magnitude, breadth, and short-term durability of binding and pseudovirus-neutralizing antibody (PsVNA) responses following a single booster dose of NVX-CoV2373 …
As part of a multicenter study evaluating homologous and heterologous COVID-19 booster vaccines, we assessed the magnitude, breadth, and sho …
Longer-Term Outcomes of HIV-Positive-to-HIV-Positive Renal Transplantation.
Selhorst P, Combrinck CE, Manning K, Botha FCJ, Labuschagne JPL, Anthony C, Matten DL, Breaud A, Clarke W, Quinn TC, Redd AD, Williamson C, Muller E. Selhorst P, et al. Among authors: manning k. N Engl J Med. 2019 Oct 3;381(14):1387-1389. doi: 10.1056/NEJMc1903013. N Engl J Med. 2019. PMID: 31577883 Free PMC article. No abstract available.
Computational Modeling of the Penn State Fontan Circulation Assist Device.
Good BC, Ponnaluri SV, Weiss WJ, Manning KB. Good BC, et al. Among authors: manning kb. ASAIO J. 2022 Dec 1;68(12):1513-1522. doi: 10.1097/MAT.0000000000001708. Epub 2022 Apr 12. ASAIO J. 2022. PMID: 35421006
To address the increasing number of failing Fontan patients, Penn State University and the Penn State Hershey Medical Center are developing a centrifugal blood pump for long-term mechanical support. Computational fluid dynamics (CFD) modeling of the Penn State Fontan Circu …
To address the increasing number of failing Fontan patients, Penn State University and the Penn State Hershey Medical Center are developing …
Longitudinal analysis of physical function in older adults: The effects of physical inactivity and exercise training.
Manning KM, Hall KS, Sloane R, Magistro D, Rabaglietti E, Lee CC, Castle S, Kopp T, Giffuni J, Katzel L, McDonald M, Miyamoto M, Pearson M, Jennings SC, Bettger JP, Morey MC. Manning KM, et al. Aging Cell. 2024 Jan;23(1):e13987. doi: 10.1111/acel.13987. Epub 2023 Sep 8. Aging Cell. 2024. PMID: 37681737 Free PMC article.
Lack of exercise contributes to systemic inflammation and is a major cause of chronic disease. The long-term impact of initiating and sustaining exercise in late life, as opposed to sustaining a sedentary lifestyle, on whole-body health measures such as physical performanc …
Lack of exercise contributes to systemic inflammation and is a major cause of chronic disease. The long-term impact of initiating and …
The use of brachiobasilic arteriovenous fistulae for haemodialysis: a single-centre descriptive study.
du Toit T, Chibuye K, Thomson D, Manning K. du Toit T, et al. Among authors: manning k. Cardiovasc J Afr. 2022 Sep-Oct 23;33(5):248-253. doi: 10.5830/CVJA-2022-006. Epub 2022 Jun 29. Cardiovasc J Afr. 2022. PMID: 35788625 Free PMC article.
However, careful monitoring, well-established referral pathways for dysfunctional fistulae and access to surgical and endovascular revision seem to be key factors in ensuring long-term patency....
However, careful monitoring, well-established referral pathways for dysfunctional fistulae and access to surgical and endovascular revision …
Baseline and annual repeat rounds of screening: implications for optimal regimens of screening.
Henschke CI, Salvatore M, Cham M, Powell CA, DiFabrizio L, Flores R, Kaufman A, Eber C, Yip R, Yankelevitz DF; International Early Lung Cancer Action Program Investigators. Henschke CI, et al. Eur Radiol. 2018 Mar;28(3):1085-1094. doi: 10.1007/s00330-017-5029-z. Epub 2017 Oct 5. Eur Radiol. 2018. PMID: 28983713

Percentages of lung cancers by cell type were significantly different (p < 0.0001) in the baseline round compared with annual rounds, reflecting length bias, as were the ratios, reflecting lead times. Long-term K-M survival rate was 100% for typical carcinoids and for a

Percentages of lung cancers by cell type were significantly different (p < 0.0001) in the baseline round compared with annual rounds, ref

Transcatheter Heart Valve Downstream Fluid Dynamics in an Accelerated Evaluation Environment.
Ponnaluri SV, Deutsch S, Sacks MS, Manning KB. Ponnaluri SV, et al. Among authors: manning kb. Ann Biomed Eng. 2021 Sep;49(9):2170-2182. doi: 10.1007/s10439-021-02751-w. Epub 2021 Feb 26. Ann Biomed Eng. 2021. PMID: 33638029
Transcatheter aortic valve replacements (TAVRs) provide minimally invasive delivery of bioprosthetic heart valves (BHVs) for the treatment of aortic valve disease. While surgical BHVs show efficacy for 8-10 years, long-term TAVR durability remains unknown. Pre-clinical tes …
Transcatheter aortic valve replacements (TAVRs) provide minimally invasive delivery of bioprosthetic heart valves (BHVs) for the treatment o …
Effects of Longitudinal Changes in Neuroticism and Stress on Cognitive Decline.
Steffens DC, Manning KJ, Wu R, Grady JJ. Steffens DC, et al. Among authors: manning kj. Am J Geriatr Psychiatry. 2023 Mar;31(3):171-179. doi: 10.1016/j.jagp.2022.10.005. Epub 2022 Oct 22. Am J Geriatr Psychiatry. 2023. PMID: 36376230
CONCLUSION: Our findings document the importance of tracking change in neuroticism and monitoring psychosocial stress over the long-term course of treatment in geriatric depression. Both factors exert important combined effects on memory over time. ...
CONCLUSION: Our findings document the importance of tracking change in neuroticism and monitoring psychosocial stress over the long-term
Longitudinal changes of brain microstructure and function in nonconcussed female rugby players.
Manning KY, Brooks JS, Dickey JP, Harriss A, Fischer L, Jevremovic T, Blackney K, Barreira C, Brown A, Bartha R, Doherty T, Fraser D, Holmes J, Dekaban GA, Menon RS. Manning KY, et al. Neurology. 2020 Jul 28;95(4):e402-e412. doi: 10.1212/WNL.0000000000009821. Epub 2020 Jun 17. Neurology. 2020. PMID: 32554762 Free PMC article.
CONCLUSIONS: Together, these findings demonstrate longitudinal changes in the microstructure and function of the brain in otherwise healthy, asymptomatic athletes participating in contact sport. Further research to understand the long-term brain health and biological impli …
CONCLUSIONS: Together, these findings demonstrate longitudinal changes in the microstructure and function of the brain in otherwise healthy, …
33 results