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Defining and Measuring Preclinical Mobility Limitation: An Expert Consensus Exercise Informed by a Scoping Review.
Richardson J, Beauchamp M, Bean J, Brach J, Chaves PHM, Guralnik JM, Jette AM, Leveille SG, Hoenig H, Manini T, Marottoli R, Porter MM, Sinclair S, Letts L, Kuspinar A, Vrkljan B, Morgan A, Mirbaha S. Richardson J, et al. Among authors: manini t. J Gerontol A Biol Sci Med Sci. 2023 Aug 27;78(9):1641-1650. doi: 10.1093/gerona/glad143. J Gerontol A Biol Sci Med Sci. 2023. PMID: 37300461 Review.
RESULTS: The scoping review and the consensus meeting support the use of the term preclinical mobility limitation (PCML) and that it should be measured using both patient-reported and performance-based measures. ...CONCLUSIONS: Currently, there are few standardized assessm …
RESULTS: The scoping review and the consensus meeting support the use of the term preclinical mobility limitation (PCML) and that it …
Effect of Physical Activity Intervention on Gait Speed by Frailty Condition: A Randomized Clinical Trial.
Custodero C, Agosti P, Anton SD, Manini TM, Lozupone M, Panza F, Pahor M, Sabbà C, Solfrizzi V. Custodero C, et al. Among authors: manini tm. J Am Med Dir Assoc. 2023 Apr;24(4):489-496. doi: 10.1016/j.jamda.2023.01.023. Epub 2023 Mar 3. J Am Med Dir Assoc. 2023. PMID: 36878264 Clinical Trial.
OBJECTIVES: There is uncertainty about effects of physical activity on physical performance, such as gait speed, among community-dwelling older adults according to their physical frailty status. We determined whether a long-term, moderate-intensity physical activity progra …
OBJECTIVES: There is uncertainty about effects of physical activity on physical performance, such as gait speed, among community-dwelling ol …
Satisfaction, Usability, and Compliance With the Use of Smartwatches for Ecological Momentary Assessment of Knee Osteoarthritis Symptoms in Older Adults: Usability Study.
Rouzaud Laborde C, Cenko E, Mardini MT, Nerella S, Kheirkhahan M, Ranka S, Fillingim RB, Corbett DB, Weber E, Rashidi P, Manini T. Rouzaud Laborde C, et al. Among authors: manini t. JMIR Aging. 2021 Jul 14;4(3):e24553. doi: 10.2196/24553. JMIR Aging. 2021. PMID: 34259638 Free PMC article.
The high compliance rates coupled with the willingness to participate in a long-term study suggest that the ROAMM app is a viable approach to remotely collecting health symptoms and behaviors for both research and clinical endeavors....
The high compliance rates coupled with the willingness to participate in a long-term study suggest that the ROAMM app is a viable app …
Three-Year, Postintervention, Follow-up Comparison of Health Care Resource Utilization and Costs in the Lifestyle Interventions and Independence for Elders (LIFE) Study.
Brown JD, Wang CY, Groessl EJ, Pahor M, Manini TM. Brown JD, et al. Among authors: manini tm. J Gerontol A Biol Sci Med Sci. 2021 Jan 18;76(2):272-276. doi: 10.1093/gerona/glaa088. J Gerontol A Biol Sci Med Sci. 2021. PMID: 32270182 Free PMC article. Clinical Trial.
BACKGROUND: The Lifestyle Interventions and Independence for Elders (LIFE) Study physical activity (PA) intervention was found to be cost-effective compared to health education (HE). However, long-term effects postintervention are unknown. METHOD: This was a secondary anal …
BACKGROUND: The Lifestyle Interventions and Independence for Elders (LIFE) Study physical activity (PA) intervention was found to be cost-ef …
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.
Glynn NW, Gmelin T, Santanasto AJ, Lovato LC, Lange-Maia BS, Nicklas BJ, Fielding RA, Manini TM, Myers VH, de Rekeneire N, Spring BJ, Pahor M, King AC, Rejeski WJ, Newman AB; Lifestyle Interventions and Independence for Elders Study Group. Glynn NW, et al. Among authors: manini tm. J Am Geriatr Soc. 2020 Mar;68(3):619-624. doi: 10.1111/jgs.16274. Epub 2019 Dec 22. J Am Geriatr Soc. 2020. PMID: 31867713 Free PMC article. Clinical Trial.
Results of baseline fatigue by intervention interaction was MMD (P = .18) and PMMD (P = .05). CONCLUSION: A long-term moderate intensity PA intervention was particularly effective at preserving mobility in older adults with higher levels of baseline fatigue. ...
Results of baseline fatigue by intervention interaction was MMD (P = .18) and PMMD (P = .05). CONCLUSION: A long-term moderate intens …
Healthcare Utilization and Physical Functioning in Older Adults in the United States.
Cheng Y, Goodin AJ, Pahor M, Manini T, Brown JD. Cheng Y, et al. Among authors: manini t. J Am Geriatr Soc. 2020 Feb;68(2):266-271. doi: 10.1111/jgs.16260. Epub 2019 Nov 22. J Am Geriatr Soc. 2020. PMID: 31755551
These estimates are conservative because they do not capture long-term care utilization due to the nature of MEPS. These results can be used to benchmark other healthcare resource benefits of interventions to maintain or improve physical functioning in older adults in noni …
These estimates are conservative because they do not capture long-term care utilization due to the nature of MEPS. These results can …
Association of Fish Oil and Physical Activity on Mobility Disability in Older Adults.
Balachandran A, Gundermann DM, Walkup MP, King AC, Ambrosius WT, Kritchevsky SB, Pahor M, Newman AB, Manini TM. Balachandran A, et al. Among authors: manini tm. Med Sci Sports Exerc. 2020 Apr;52(4):859-867. doi: 10.1249/MSS.0000000000002195. Med Sci Sports Exerc. 2020. PMID: 31688650 Free PMC article. Clinical Trial.
PURPOSE: This study aimed to examine whether long-term fish oil (FO) supplementation is associated with a lower risk of mobility disability and enhances benefits of physical activity (PA). ...
PURPOSE: This study aimed to examine whether long-term fish oil (FO) supplementation is associated with a lower risk of mobility disa …
Perception of Older Adults Toward Smartwatch Technology for Assessing Pain and Related Patient-Reported Outcomes: Pilot Study.
Manini TM, Mendoza T, Battula M, Davoudi A, Kheirkhahan M, Young ME, Weber E, Fillingim RB, Rashidi P. Manini TM, et al. JMIR Mhealth Uhealth. 2019 Mar 26;7(3):e10044. doi: 10.2196/10044. JMIR Mhealth Uhealth. 2019. PMID: 30912756 Free PMC article.
Complexity and diversity of the pain experience across time and people and its fluctuations across and within days show the need for valid pain reports that do not rely on patient's long-term recall capability. Smartwatches can be used as digital ecological momentary asses …
Complexity and diversity of the pain experience across time and people and its fluctuations across and within days show the need for valid p …
Associations between ACE-Inhibitors, Angiotensin Receptor Blockers, and Lean Body Mass in Community Dwelling Older Women.
Bea JW, Wassertheil-Smoller S, Wertheim BC, Klimentidis Y, Chen Z, Zaslavsky O, Manini TM, Womack CR, Kroenke CH, LaCroix AZ, Thomson CA. Bea JW, et al. Among authors: manini tm. J Aging Res. 2018 Feb 19;2018:8491092. doi: 10.1155/2018/8491092. eCollection 2018. J Aging Res. 2018. PMID: 29670769 Free PMC article.
Nevertheless, ACE-I/ARB use does not appear to negatively impact LBM in the long term....
Nevertheless, ACE-I/ARB use does not appear to negatively impact LBM in the long term....
Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial.
Trombetti A, Hars M, Hsu FC, Reid KF, Church TS, Gill TM, King AC, Liu CK, Manini TM, McDermott MM, Newman AB, Rejeski WJ, Guralnik JM, Pahor M, Fielding RA; LIFE Study Investigators. Trombetti A, et al. Among authors: manini tm. Ann Intern Med. 2018 Mar 6;168(5):309-316. doi: 10.7326/M16-2011. Epub 2018 Jan 9. Ann Intern Med. 2018. PMID: 29310138 Free PMC article. Clinical Trial.
BACKGROUND: Limited evidence suggests that physical activity may prevent frailty and associated negative outcomes in older adults. Definitive data from large long-term randomized trials are lacking. OBJECTIVE: To determine whether a long-term, structured, moderate-i …
BACKGROUND: Limited evidence suggests that physical activity may prevent frailty and associated negative outcomes in older adults. Definitiv …
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