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FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia.
Lan T, Morgan DA, Rahmouni K, Sonoda J, Fu X, Burgess SC, Holland WL, Kliewer SA, Mangelsdorf DJ. Lan T, et al. Among authors: mangelsdorf dj. Cell Metab. 2017 Nov 7;26(5):709-718.e3. doi: 10.1016/j.cmet.2017.09.005. Epub 2017 Oct 5. Cell Metab. 2017. PMID: 28988823 Free PMC article.
Surprisingly, FGF19 and FGF21 actions in liver and adipose tissue are not required for their longer-term weight loss and glycemic effects. In contrast, beta-Klotho in neurons is essential for both FGF19 and FGF21 to cause weight loss and lower glucose and insulin levels. . …
Surprisingly, FGF19 and FGF21 actions in liver and adipose tissue are not required for their longer-term weight loss and glycemic eff …
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.
Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA. Inagaki T, et al. Among authors: mangelsdorf dj. Cell Metab. 2007 Jun;5(6):415-25. doi: 10.1016/j.cmet.2007.05.003. Cell Metab. 2007. PMID: 17550777 Free article.
FGF21 also reduces physical activity and promotes torpor, a short-term hibernation-like state of regulated hypothermia that conserves energy. ...
FGF21 also reduces physical activity and promotes torpor, a short-term hibernation-like state of regulated hypothermia that conserves …
International Union of Pharmacology. LX. Retinoic acid receptors.
Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. Germain P, et al. Among authors: mangelsdorf dj. Pharmacol Rev. 2006 Dec;58(4):712-25. doi: 10.1124/pr.58.4.4. Pharmacol Rev. 2006. PMID: 17132850 Review.
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARalpha, RARbeta, and RARgamma), members of the nuclear hormone receptor superfamily. ...
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARalpha, RARbeta, and RARgamma), members of the …