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The Role of Alterations in Alpha-Klotho and FGF-23 in Kidney Transplantation and Kidney Donation.
Gupta M, Orozco G, Rao M, Gedaly R, Malluche HH, Neyra JA. Gupta M, et al. Among authors: malluche hh. Front Med (Lausanne). 2022 May 6;9:803016. doi: 10.3389/fmed.2022.803016. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35602513 Free PMC article. Review.
On the other hand, kidney donation is also associated with endocrine and metabolic adaptations that include transient increases in circulating FGF-23 and decreases in alpha-Klotho levels. However, the long-term impact of these alterations and their clinical relevance have …
On the other hand, kidney donation is also associated with endocrine and metabolic adaptations that include transient increases in circulati …
Bone Quality and Fractures in Women With Osteoporosis Treated With Bisphosphonates for 1 to 14 Years.
Malluche HH, Chen J, Lima F, Liu LJ, Monier-Faugere MC, Pienkowski D. Malluche HH, et al. JBMR Plus. 2021 Sep 21;5(11):e10549. doi: 10.1002/jbm4.10549. eCollection 2021 Nov. JBMR Plus. 2021. PMID: 34761151 Free PMC article.
Application of artificial intelligence enabled analysis of large quantities of structural, cellular, mineral, and matrix bone-quality parameters to determine relationships with long-term oral bisphosphonate treatment and fracture. Infrared spectroscopy provides clinically …
Application of artificial intelligence enabled analysis of large quantities of structural, cellular, mineral, and matrix bone-quality parame …
Long-term outcomes and management considerations after parathyroidectomy in the dialysis patient.
Kakani E, Sloan D, Sawaya BP, El-Husseini A, Malluche HH, Rao M. Kakani E, et al. Among authors: malluche hh. Semin Dial. 2019 Nov;32(6):541-552. doi: 10.1111/sdi.12833. Epub 2019 Jul 16. Semin Dial. 2019. PMID: 31313380 Review.
There is considerable subjectivity in defining and diagnosing these conditions, given that we poorly understand the optimal PTH targets (particularly post PTX) needed to maintain bone and vascular health. While lowering PTH after PTX decreases bone turnover, long-term chan …
There is considerable subjectivity in defining and diagnosing these conditions, given that we poorly understand the optimal PTH targets (par …
Bone disease after renal transplantation.
Malluche HH, Monier-Faugere MC, Herberth J. Malluche HH, et al. Nat Rev Nephrol. 2010 Jan;6(1):32-40. doi: 10.1038/nrneph.2009.192. Epub 2009 Nov 17. Nat Rev Nephrol. 2010. PMID: 19918255 Free PMC article. Review.
In light of greatly improved long-term patient and graft survival after renal transplantation, improving other clinical outcomes such as risk of fracture and cardiovascular disease is of paramount importance. ...
In light of greatly improved long-term patient and graft survival after renal transplantation, improving other clinical outcomes such …
Moderately high consumption of ethanol suppresses bone resorption in ovariectomized but not in sexually intact adult female rats.
Fanti P, Monier-Faugere MC, Geng Z, Cohen D, Malluche HH. Fanti P, et al. Among authors: malluche hh. Alcohol Clin Exp Res. 1997 Sep;21(6):1150-4. doi: 10.1111/j.1530-0277.1997.tb04266.x. Alcohol Clin Exp Res. 1997. PMID: 9309330

Indeed, the peripheral blood monocytic cells (PBMC) from the OVX-C rats produced higher amounts of TNF-alpha than the PBMC from the SHAM-C rats (p < 0.05) and administration of ethanol prevented this increase in OVX rats but had no effect in SHAM rats. In summary, short-ter

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Indeed, the peripheral blood monocytic cells (PBMC) from the OVX-C rats produced higher amounts of TNF-alpha than the PBMC from the SHAM-C r …
Calcitonin prevents bone loss but decreases osteoblastic activity in ovariohysterectomized beagle dogs.
Monier-Faugere MC, Geng Z, Qi Q, Arnala I, Malluche HH. Monier-Faugere MC, et al. Among authors: malluche hh. J Bone Miner Res. 1996 Apr;11(4):446-55. doi: 10.1002/jbmr.5650110405. J Bone Miner Res. 1996. PMID: 8992875 Free article.
The data show that calcitonin, because of its antiresorptive effects, can prevent bone loss after cessation of ovarian function. However, short-term treatment with calcitonin does not stimulate osteoblast activity; on the contrary, it exerts a negative effect on osteoblast …
The data show that calcitonin, because of its antiresorptive effects, can prevent bone loss after cessation of ovarian function. However, sh …
Early therapy of renal bone disease with calcitriol: a prospective double-blind study.
Baker LR, Abrams SM, Roe CJ, Faugere MC, Fanti P, Subayti Y, Malluche HH. Baker LR, et al. Among authors: malluche hh. Kidney Int Suppl. 1989 Nov;27:S140-2. Kidney Int Suppl. 1989. PMID: 2699994 Clinical Trial.
Further investigation is required to determine whether alternative therapeutic strategies (smaller doses or intermittent therapy) may avoid the potential for suppressing bone turnover to abnormally low levels in the long term....
Further investigation is required to determine whether alternative therapeutic strategies (smaller doses or intermittent therapy) may avoid …
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