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Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells.
Heslop KA, Burger P, Kappler C, Solanki AK, Gooz M, Peterson YK, Mills C, Benton T, Duncan SA, Woster PM, Maldonado EN. Heslop KA, et al. Among authors: maldonado en. Biomed Pharmacother. 2022 Jun;150:112928. doi: 10.1016/j.biopha.2022.112928. Epub 2022 Apr 18. Biomed Pharmacother. 2022. PMID: 35447542 Free PMC article.
SC18 bound to VDAC1, as assessed by a thermal shift assay. Short-term treatment with SC18 decreased deltapsim in SNU-449 and HepG2 human hepatocarcinoma cells. ...In addition, SC18 decreased mitochondrial NADH and cellular ATP production; and increased basal respiration. L …
SC18 bound to VDAC1, as assessed by a thermal shift assay. Short-term treatment with SC18 decreased deltapsim in SNU-449 and HepG2 hu …
A Clinical Trial Comparing Smoking Cessation Interventions at Two Levels of Intensity in Stroke Patients, Stratified by the Presence of Insular Cortex Lesions.
Suñer-Soler R, Grau-Martín A, Terceño M, Silva Y, Maldonado E, Gras ME, Font-Mayolas S, Rodrigo-Gil J, Serena J. Suñer-Soler R, et al. Among authors: maldonado e. Nicotine Tob Res. 2022 Jan 1;24(1):44-52. doi: 10.1093/ntr/ntab144. Nicotine Tob Res. 2022. PMID: 34245288 Clinical Trial.
IMPLICATIONS: This two-year clinical trial compares for the first time the efficacy of two different intensities of smoking cessation intervention in stroke patients, taking into consideration the effect of the insula. Good results are obtained both in the short and medium-ter …
IMPLICATIONS: This two-year clinical trial compares for the first time the efficacy of two different intensities of smoking cessation interv …
Conceptual Design and Prototyping for a Primate Health History Knowledge Model.
Zhao MQ, Maldonado E, Kensler TB, Kohn LAP, Guatelli-Steinberg D, Wang Q. Zhao MQ, et al. Among authors: maldonado e. Adv Comput Vis Comput Biol (2020). 2021;2021:509-520. doi: 10.1007/978-3-030-71051-4_40. Epub 2021 Aug 6. Adv Comput Vis Comput Biol (2020). 2021. PMID: 35441181 Free PMC article.
However, how to integrate data from multiple disciplines and render them compatible with each other for datamining and in-depth study is always challenging. In a long-term project, we have started a collaborative research endeavor to examine the health history of a free-ra …
However, how to integrate data from multiple disciplines and render them compatible with each other for datamining and in-depth study is alw …
Factors associated with prolonged hospital stay after laparoscopic adrenalectomy.
Rodríguez-Hermosa JI, Delisau O, Planellas-Giné P, Cornejo L, Ranea A, Maldonado E, Fernández-Real JM, Codina-Cazador A. Rodríguez-Hermosa JI, et al. Among authors: maldonado e. Updates Surg. 2021 Apr;73(2):693-702. doi: 10.1007/s13304-020-00880-w. Epub 2020 Sep 17. Updates Surg. 2021. PMID: 32940830
Laparoscopy is the standard technique for resecting adrenal tumors, but short-term outcomes such as length of stay (LOS) vary widely between centers. ...
Laparoscopy is the standard technique for resecting adrenal tumors, but short-term outcomes such as length of stay (LOS) vary widely …
Age negatively impacts reproduction in high-ranking male rhesus macaques on Cayo Santiago, Puerto Rico.
Milich KM, Ruiz-Lambides A, Maldonado E, Maestripieri D. Milich KM, et al. Among authors: maldonado e. Sci Rep. 2020 Aug 3;10(1):13044. doi: 10.1038/s41598-020-69922-y. Sci Rep. 2020. PMID: 32747726 Free PMC article.
We recorded behavioral data for 21 adult males across 9 social groups during the 2013 mating season. Additionally, we used paternity data from the long-term database to determine the number of offspring each subject sired over his lifetime and during the study period. ...
We recorded behavioral data for 21 adult males across 9 social groups during the 2013 mating season. Additionally, we used paternity data fr …
Adaptation to low parasite abundance affects immune investment and immunopathological responses of cavefish.
Peuß R, Box AC, Chen S, Wang Y, Tsuchiya D, Persons JL, Kenzior A, Maldonado E, Krishnan J, Scharsack JP, Slaughter BD, Rohner N. Peuß R, et al. Among authors: maldonado e. Nat Ecol Evol. 2020 Oct;4(10):1416-1430. doi: 10.1038/s41559-020-1234-2. Epub 2020 Jul 20. Nat Ecol Evol. 2020. PMID: 32690906
Reduced parasitic infection rates in the developed world are suspected to underlie the rising prevalence of autoimmune disorders. However, the long-term evolutionary consequences of decreased parasite exposure on an immune system are not well understood. ...Additionally, i …
Reduced parasitic infection rates in the developed world are suspected to underlie the rising prevalence of autoimmune disorders. However, t …
Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability.
Glynn NW, Gmelin T, Santanasto AJ, Lovato LC, Lange-Maia BS, Nicklas BJ, Fielding RA, Manini TM, Myers VH, de Rekeneire N, Spring BJ, Pahor M, King AC, Rejeski WJ, Newman AB; Lifestyle Interventions and Independence for Elders Study Group. Glynn NW, et al. J Am Geriatr Soc. 2020 Mar;68(3):619-624. doi: 10.1111/jgs.16274. Epub 2019 Dec 22. J Am Geriatr Soc. 2020. PMID: 31867713 Free PMC article. Clinical Trial.
Results of baseline fatigue by intervention interaction was MMD (P = .18) and PMMD (P = .05). CONCLUSION: A long-term moderate intensity PA intervention was particularly effective at preserving mobility in older adults with higher levels of baseline fatigue. ...
Results of baseline fatigue by intervention interaction was MMD (P = .18) and PMMD (P = .05). CONCLUSION: A long-term moderate intens …
Statin-dependent modulation of mitochondrial metabolism in cancer cells is independent of cholesterol content.
Christie CF, Fang D, Hunt EG, Morris ME, Rovini A, Heslop KA, Beeson GC, Beeson CC, Maldonado EN. Christie CF, et al. Among authors: maldonado en. FASEB J. 2019 Jul;33(7):8186-8201. doi: 10.1096/fj.201802723R. Epub 2019 Apr 5. FASEB J. 2019. PMID: 30951369 Free PMC article.
Mitochondrial membrane potential (deltapsi), a readout of mitochondrial metabolism, is sustained by the oxidation of respiratory substrates in the Krebs cycle to generate NADH and flavin adenine dinucleotide, which are further oxidized by the respiratory chain. Here, we studied t …
Mitochondrial membrane potential (deltapsi), a readout of mitochondrial metabolism, is sustained by the oxidation of respiratory substrates …
Population Genetic Structure of the Cayo Santiago Colony of Rhesus Macaques (Macaca mulatta).
Kanthaswamy S, Oldt RF, Ng J, Ruiz-Lambides AV, Maldonado E, Martínez MI, Sariol CA. Kanthaswamy S, et al. Among authors: maldonado e. J Am Assoc Lab Anim Sci. 2017 Jul 1;56(4):396-401. J Am Assoc Lab Anim Sci. 2017. PMID: 28724489 Free PMC article.
In-depth assessments of the colony's population genetic and pedigree structures provide a starting point for improving the colony's long-term management program. We evaluated the degree of genetic variation and coefficients of inbreeding and kinship of the Cayo Santiago co …
In-depth assessments of the colony's population genetic and pedigree structures provide a starting point for improving the colony's long- …
17 results