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Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice.
Durani LW, Hamezah HS, Ibrahim NF, Yanagisawa D, Nasaruddin ML, Mori M, Azizan KA, Damanhuri HA, Makpol S, Wan Ngah WZ, Tooyama I. Durani LW, et al. Among authors: makpol s. J Alzheimers Dis. 2018;64(1):249-267. doi: 10.3233/JAD-170880. J Alzheimers Dis. 2018. PMID: 29889072 Free PMC article.
However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavioral impairments and brain metabolites in (15 months old) AbetaPP/PS1 double transgenic (Tg) Alzheimer's disease (AD) mice. ...
However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavior …
Effect of the combination of gelam honey and ginger on oxidative stress and metabolic profile in streptozotocin-induced diabetic Sprague-Dawley rats.
Sani NF, Belani LK, Sin CP, Rahman SN, Das S, Chi TZ, Makpol S, Yusof YA. Sani NF, et al. Among authors: makpol s. Biomed Res Int. 2014;2014:160695. doi: 10.1155/2014/160695. Epub 2014 Apr 16. Biomed Res Int. 2014. PMID: 24822178 Free PMC article.
Diabetic complications occur as a result of increased reactive oxygen species (ROS) due to long term hyperglycaemia. Honey and ginger have been shown to exhibit antioxidant activity which can scavenge ROS. ...
Diabetic complications occur as a result of increased reactive oxygen species (ROS) due to long term hyperglycaemia. Honey and ginger …
Long-term in vitro expansion of human adipose-derived stem cells showed low risk of tumourigenicity.
Zaman WS, Makpol S, Sathapan S, Chua KH. Zaman WS, et al. Among authors: makpol s. J Tissue Eng Regen Med. 2014 Jan;8(1):67-76. doi: 10.1002/term.1501. Epub 2012 May 2. J Tissue Eng Regen Med. 2014. PMID: 22552847
Therefore, the aim of this study was to investigate the effect of long-term in vitro expansion on human adipose-derived stem cells (ASCs). ...Our data showed that ASCs lost their fibroblastic feature in long-term culture. The population doubling time of ASCs increas …
Therefore, the aim of this study was to investigate the effect of long-term in vitro expansion on human adipose-derived stem cells (A …
Alteration of gene expression levels during osteogenic induction of human adipose derived stem cells in long-term culture.
Safwani WK, Makpol S, Sathapan S, Chua KH. Safwani WK, et al. Among authors: makpol s. Cell Tissue Bank. 2013 Jun;14(2):289-301. doi: 10.1007/s10561-012-9309-1. Epub 2012 Apr 5. Cell Tissue Bank. 2013. PMID: 22476937
For clinical usage, ASCs need to be expanded in vitro for a period of time to get sufficient cells for transplantation into patients. However, the impact of long-term culture on ASCs molecular characteristics has not been established yet. ...LPL and AP2 decreased but PPAR- …
For clinical usage, ASCs need to be expanded in vitro for a period of time to get sufficient cells for transplantation into patients. Howeve …
The impact of long-term in vitro expansion on the senescence-associated markers of human adipose-derived stem cells.
Safwani WK, Makpol S, Sathapan S, Chua KH. Safwani WK, et al. Among authors: makpol s. Appl Biochem Biotechnol. 2012 Apr;166(8):2101-13. doi: 10.1007/s12010-012-9637-4. Epub 2012 Mar 7. Appl Biochem Biotechnol. 2012. PMID: 22391697
However, their safety and efficacy issue remain a major concern especially after long-term in vitro expansion. The aim of this study was to investigate the fundamental changes of ASCs in long-term culture by studying the morphological feature, growth kinetic, surfac …
However, their safety and efficacy issue remain a major concern especially after long-term in vitro expansion. The aim of this study …
The changes of stemness biomarkers expression in human adipose-derived stem cells during long-term manipulation.
Wan Safwani WK, Makpol S, Sathapan S, Chua KH. Wan Safwani WK, et al. Among authors: makpol s. Biotechnol Appl Biochem. 2011 Jul-Aug;58(4):261-70. doi: 10.1002/bab.38. Epub 2011 Aug 9. Biotechnol Appl Biochem. 2011. PMID: 21838801
However, the stemness biomarkers, which marked the safety and efficacy of ASCs in accordance with the good manufacturing practice guidelines, is not yet well established. This study was designed to investigate the effect of long-term culture on the stemness properties of A …
However, the stemness biomarkers, which marked the safety and efficacy of ASCs in accordance with the good manufacturing practice guidelines …
Stemness gene expression profile of human adipose derived stem cells in long-term culture.
Zaman WS, Makpol S, Santhapan S, Chua KH. Zaman WS, et al. Among authors: makpol s. Med J Malaysia. 2008 Jul;63 Suppl A:61-2. Med J Malaysia. 2008. PMID: 19024984
The objective of this study was to investigate the stemness gene expression of human adipose tissue derived stem cells (ADSCs) in long-term culture using quantitative RT-PCR technique. Our data showed that the expression level of Sox-2, Rex-1, FGF-4, Nanog, Nestin, BST-1, …
The objective of this study was to investigate the stemness gene expression of human adipose tissue derived stem cells (ADSCs) in long-te …