Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

10 results

Filters applied: . Clear all
Page 1
Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial.
Kiguli S, Olopot-Olupot P, Alaroker F, Engoru C, Opoka RO, Tagoola A, Hamaluba M, Mnjalla H, Mpoya A, Mogaka C, Nalwanga D, Nabawanuka E, Nokes J, Nyaigoti C, Briend A, van Woensel JBM, Grieve R, Sadique Z, Williams TN, Thomas K, Harrison DA, Rowan K, Maitland K. Kiguli S, et al. Among authors: maitland k. Wellcome Open Res. 2021 Oct 18;6:221. doi: 10.12688/wellcomeopenres.17123.2. eCollection 2021. Wellcome Open Res. 2021. PMID: 34734123 Free PMC article.
Background: To prevent poor long-term outcomes (deaths and readmissions) the integrated global action plan for pneumonia and diarrhoea recommends under the 'Treat' element of Protect, Prevent and Treat interventions the importance of continued feeding but gives no specific …
Background: To prevent poor long-term outcomes (deaths and readmissions) the integrated global action plan for pneumonia and diarrhoe …
Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials.
Herrett E, Williamson E, Brack K, Beaumont D, Perkins A, Thayne A, Shakur-Still H, Roberts I, Prowse D, Goldacre B, van Staa T, MacDonald TM, Armitage J, Wimborne J, Melrose P, Singh J, Brooks L, Moore M, Hoffman M, Smeeth L; StatinWISE Trial Group. Herrett E, et al. BMJ. 2021 Feb 24;372:n135. doi: 10.1136/bmj.n135. BMJ. 2021. PMID: 33627334 Free PMC article. Clinical Trial.
Two thirds of those completing the trial reported restarting long term treatment with statins. CONCLUSIONS: No overall effect of atorvastatin 20 mg on muscle symptoms compared with placebo was found in participants who had previously reported severe muscle symptoms when ta …
Two thirds of those completing the trial reported restarting long term treatment with statins. CONCLUSIONS: No overall effect of ator …
The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study.
Uyoga S, Macharia AW, Mochamah G, Ndila CM, Nyutu G, Makale J, Tendwa M, Nyatichi E, Ojal J, Otiende M, Shebe M, Awuondo KO, Mturi N, Peshu N, Tsofa B, Maitland K, Scott JAG, Williams TN. Uyoga S, et al. Among authors: maitland k. Lancet Glob Health. 2019 Oct;7(10):e1458-e1466. doi: 10.1016/S2214-109X(19)30328-6. Epub 2019 Aug 23. Lancet Glob Health. 2019. PMID: 31451441 Free PMC article.
In this study, we aimed to describe the comparative incidence of specific clinical outcomes among children aged between birth and 5 years with and without sickle cell disease, who were resident within the Kilifi area of Kenya. ...The emphasis must now move towards early de …
In this study, we aimed to describe the comparative incidence of specific clinical outcomes among children aged between birth and 5 y …
Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial.
Mallewa J, Szubert AJ, Mugyenyi P, Chidziva E, Thomason MJ, Chepkorir P, Abongomera G, Baleeta K, Etyang A, Warambwa C, Melly B, Mudzingwa S, Kelly C, Agutu C, Wilkes H, Nkomani S, Musiime V, Lugemwa A, Pett SL, Bwakura-Dangarembizi M, Prendergast AJ, Gibb DM, Walker AS, Berkley JA; REALITY trial team. Mallewa J, et al. Lancet HIV. 2018 May;5(5):e231-e240. doi: 10.1016/S2352-3018(18)30038-9. Epub 2018 Apr 10. Lancet HIV. 2018. PMID: 29653915 Free PMC article. Clinical Trial.
INTERPRETATION: In severely immunocompromised HIV-infected individuals, providing RUSF universally at ART initiation, compared with providing RUTF to severely malnourished individuals only, improved short-term weight gain but not mortality. A change in policy to provide nu …
INTERPRETATION: In severely immunocompromised HIV-infected individuals, providing RUSF universally at ART initiation, compared with providin …
Children's Oxygen Administration Strategies Trial (COAST):  A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia.
Maitland K, Kiguli S, Opoka RO, Olupot-Olupot P, Engoru C, Njuguna P, Bandika V, Mpoya A, Bush A, Williams TN, Grieve R, Sadique Z, Fraser J, Harrison D, Rowan K. Maitland K, et al. Wellcome Open Res. 2018 Jan 9;2:100. doi: 10.12688/wellcomeopenres.12747.2. eCollection 2017. Wellcome Open Res. 2018. PMID: 29383331 Free PMC article.

Methods: In 4200 African children, aged 2 months to 12 years, presenting to 5 hospitals in East Africa with respiratory distress and hypoxia (oxygen saturation < 92%), the COAST trial will simultaneously evaluate two related interventions (targeted use of oxygen with respect t

…
Methods: In 4200 African children, aged 2 months to 12 years, presenting to 5 hospitals in East Africa with respiratory distress and hypoxia …
Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after 6years of macrocyclic lactone use.
Laing R, Maitland K, Lecová L, Skuce PJ, Tait A, Devaney E. Laing R, et al. Among authors: maitland k. Int J Parasitol. 2016 Sep;46(10):621-30. doi: 10.1016/j.ijpara.2016.03.010. Epub 2016 May 11. Int J Parasitol. 2016. PMID: 27179994 Free PMC article.
While some between-population comparisons of individual farms with and without long-term macrocyclic lactone use identified statistically significant differences in allele frequency and/or fixation index at the Hc-lgc-37, Hc-glc-5 or Hc-avr-14 loci, we found no consistent …
While some between-population comparisons of individual farms with and without long-term macrocyclic lactone use identified statistic …
Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial.
Mpoya A, Kiguli S, Olupot-Olupot P, Opoka RO, Engoru C, Mallewa M, Chimalizeni Y, Kennedy N, Kyeyune D, Wabwire B, M'baya B, Bates I, Urban B, von Hensbroek MB, Heyderman R, Thomason MJ, Uyoga S, Williams TN, Gibb DM, George EC, Walker AS, Maitland K. Mpoya A, et al. Among authors: maitland k. Trials. 2015 Dec 29;16:593. doi: 10.1186/s13063-015-1112-4. Trials. 2015. PMID: 26715196 Free PMC article. Clinical Trial.
The trial will simultaneously evaluate (in a factorial trial with a 3 x 2 x 2 design) 3 ways to reduce short-term and longer-term mortality and morbidity following admission to hospital with severe anaemia in African children. ...
The trial will simultaneously evaluate (in a factorial trial with a 3 x 2 x 2 design) 3 ways to reduce short-term and longer-term …
Estimation of the number of fluorescent end-members for quantitative analysis of multispectral FLIM data.
Gutierrez-Navarro O, Campos-Delgado DU, Arce-Santana ER, Maitland KC, Cheng S, Jabbour J, Malik B, Cuenca R, Jo JA. Gutierrez-Navarro O, et al. Among authors: maitland kc. Opt Express. 2014 May 19;22(10):12255-72. doi: 10.1364/OE.22.012255. Opt Express. 2014. PMID: 24921344 Free PMC article.
The algorithm also provided a better description of atherosclerotic plaques in term of their endogenous fluorophores. These results demonstrate the potential of this methodology to provide quantitative description of tissue biochemical composition....
The algorithm also provided a better description of atherosclerotic plaques in term of their endogenous fluorophores. These results d …
Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia.
Olupot-Olupot P, Engoru C, Thompson J, Nteziyaremye J, Chebet M, Ssenyondo T, Dambisya CM, Okuuny V, Wokulira R, Amorut D, Ongodia P, Mpoya A, Williams TN, Uyoga S, Macharia A, Gibb DM, Walker AS, Maitland K. Olupot-Olupot P, et al. Among authors: maitland k. BMC Med. 2014 Apr 25;12:67. doi: 10.1186/1741-7015-12-67. BMC Med. 2014. PMID: 24767094 Free PMC article. Clinical Trial.
Future testing in a large, pragmatic clinical trial to establish the effect on short and longer-term survival is warranted. TRIAL REGISTRATION: ClinicalTrials.Gov identifier: NCT01461590 registered 26 October 2011....
Future testing in a large, pragmatic clinical trial to establish the effect on short and longer-term survival is warranted. TRIAL REG …
Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.
Taldone T, Gillan V, Sun W, Rodina A, Patel P, Maitland K, O'Neill K, Chiosis G, Devaney E. Taldone T, et al. Among authors: maitland k. PLoS Negl Trop Dis. 2010 Jun 15;4(6):e714. doi: 10.1371/journal.pntd.0000714. PLoS Negl Trop Dis. 2010. PMID: 20559560 Free PMC article.
The identification of compounds that target adult worms has been a long-term goal of WHO. Here we describe a fluorescence polarization assay for the identification of compounds that target Hsp90 in adult filarial worms. ...
The identification of compounds that target adult worms has been a long-term goal of WHO. Here we describe a fluorescence polarizatio …