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Identification of two distinct phylogenomic lineages and model strains for the understudied cystic fibrosis lung pathogen Burkholderia multivorans.
Parfitt KM, Green AE, Connor TR, Neill DR, Mahenthiralingam E. Parfitt KM, et al. Among authors: mahenthiralingam e. Microbiology (Reading). 2023 Aug;169(8):001366. doi: 10.1099/mic.0.001366. Microbiology (Reading). 2023. PMID: 37526960 Free PMC article.
B. multivorans CF strains BCC0033 and BCC0084, and the environmental reference strain, ATCC 17616, were all capable of short-term survival within a murine lung infection model. By mapping the population biology, identifying lineage-specific PCRs and model strains, we provi …
B. multivorans CF strains BCC0033 and BCC0084, and the environmental reference strain, ATCC 17616, were all capable of short-term sur …
Construction and evaluation of a bioluminescent Pseudomonas aeruginosa reporter for use in preservative efficacy testing.
Rushton L, Donoghue D, Bull M, Jay P, Mahenthiralingam E. Rushton L, et al. Among authors: mahenthiralingam e. Microbiology (Reading). 2021 Aug;167(8):001072. doi: 10.1099/mic.0.001072. Microbiology (Reading). 2021. PMID: 34382924 Free PMC article.
Overall, while initial bioluminescence read-outs were less suited to current PET requirements, it shows promise as an early, direct indicator of bacterial regrowth in the context of long-term evaluation of preservative efficacy....
Overall, while initial bioluminescence read-outs were less suited to current PET requirements, it shows promise as an early, direct indicato …
Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy.
Oakley JL, Weiser R, Powell LC, Forton J, Mahenthiralingam E, Rye PD, Hill KE, Thomas DW, Pritchard MF. Oakley JL, et al. Among authors: mahenthiralingam e. mSphere. 2021 Jan 20;6(1):e01216-20. doi: 10.1128/mSphere.01216-20. mSphere. 2021. PMID: 33472983 Free PMC article.
OligoG CF-5/20 has been shown to alter sputum viscoelasticity, disrupt mucin polymer networks, and disrupt MDR pseudomonal biofilms. Long-term exposure to inhaled therapeutics may induce selective evolutionary pressures on bacteria within the lung biofilm. Here, a bead bio …
OligoG CF-5/20 has been shown to alter sputum viscoelasticity, disrupt mucin polymer networks, and disrupt MDR pseudomonal biofilms. Long- …
Burkholderia species infections in patients with cystic fibrosis in British Columbia, Canada. 30 years' experience.
Zlosnik JE, Zhou G, Brant R, Henry DA, Hird TJ, Mahenthiralingam E, Chilvers MA, Wilcox P, Speert DP. Zlosnik JE, et al. Among authors: mahenthiralingam e. Ann Am Thorac Soc. 2015 Jan;12(1):70-8. doi: 10.1513/AnnalsATS.201408-395OC. Ann Am Thorac Soc. 2015. PMID: 25474359
During this time, our understanding of their multispecies taxonomy and infection control has evolved substantially. OBJECTIVES: To evaluate the long-term (30 year) epidemiology and clinical outcome of Burkholderia infection in CF, and fully define the risks associated with …
During this time, our understanding of their multispecies taxonomy and infection control has evolved substantially. OBJECTIVES: To evaluate …
The effect of cationic microbicide exposure against Burkholderia cepacia complex (Bcc); the use of Burkholderia lata strain 383 as a model bacterium.
Knapp L, Rushton L, Stapleton H, Sass A, Stewart S, Amezquita A, McClure P, Mahenthiralingam E, Maillard JY. Knapp L, et al. Among authors: mahenthiralingam e. J Appl Microbiol. 2013 Nov;115(5):1117-26. doi: 10.1111/jam.12320. Epub 2013 Sep 3. J Appl Microbiol. 2013. PMID: 23910391 Free article.
METHODS AND RESULTS: The susceptibility of B. lata strain 383 to CHG and BZC and a range of antibiotics was determined using standardized MIC, MBC and antibiotic susceptibility testing protocols before and after short-term exposure to a low microbicide concentration. Measu …
METHODS AND RESULTS: The susceptibility of B. lata strain 383 to CHG and BZC and a range of antibiotics was determined using standardized MI …
Intravenous antibiotics reduce the presence of Aspergillus in adult cystic fibrosis sputum.
Baxter CG, Rautemaa R, Jones AM, Webb AK, Bull M, Mahenthiralingam E, Denning DW. Baxter CG, et al. Among authors: mahenthiralingam e. Thorax. 2013 Jul;68(7):652-7. doi: 10.1136/thoraxjnl-2012-202412. Epub 2013 Mar 19. Thorax. 2013. PMID: 23513028
BACKGROUND: Pseudomonas aeruginosa and Aspergillus fumigatus frequently co-colonise the airways of patients with cystic fibrosis (CF). This study aimed to assess the impact of short-term administration of intravenous antipseudomonal antibiotics during CF exacerbations on t …
BACKGROUND: Pseudomonas aeruginosa and Aspergillus fumigatus frequently co-colonise the airways of patients with cystic fibrosis (CF). This …
Role of swarming in the formation of crystalline Proteus mirabilis biofilms on urinary catheters.
Jones BV, Mahenthiralingam E, Sabbuba NA, Stickler DJ. Jones BV, et al. Among authors: mahenthiralingam e. J Med Microbiol. 2005 Sep;54(Pt 9):807-813. doi: 10.1099/jmm.0.46123-0. J Med Microbiol. 2005. PMID: 16091430
The care of many patients undergoing long-term bladder catheterization is frequently complicated by infection with Proteus mirabilis. ...
The care of many patients undergoing long-term bladder catheterization is frequently complicated by infection with Proteus mirabilis. …
Genotyping demonstrates that the strains of Proteus mirabilis from bladder stones and catheter encrustations of patients undergoing long-term bladder catheterization are identical.
Sabbuba NA, Stickler DJ, Mahenthiralingam E, Painter DJ, Parkin J, Feneley RC. Sabbuba NA, et al. Among authors: mahenthiralingam e. J Urol. 2004 May;171(5):1925-8. doi: 10.1097/01.ju.0000123062.26461.f9. J Urol. 2004. PMID: 15076313
MATERIALS AND METHODS: The first 100 patients attending a clinic for patients experiencing problems with the management of long-term bladder catheters were studied. Flexible cystoscopy was used to detect bladder stones. ...
MATERIALS AND METHODS: The first 100 patients attending a clinic for patients experiencing problems with the management of long-term …
Molecular epidemiology of Proteus mirabilis infections of the catheterized urinary tract.
Sabbuba NA, Mahenthiralingam E, Stickler DJ. Sabbuba NA, et al. Among authors: mahenthiralingam e. J Clin Microbiol. 2003 Nov;41(11):4961-5. doi: 10.1128/JCM.41.11.4961-4965.2003. J Clin Microbiol. 2003. PMID: 14605124 Free PMC article.
Proteus mirabilis compromises the care of many patients undergoing long-term indwelling bladder catheterization. It forms crystalline bacterial biofilms in catheters which block the flow of urine, causing either incontinence due to leakage or painful distention of the blad …
Proteus mirabilis compromises the care of many patients undergoing long-term indwelling bladder catheterization. It forms crystalline …
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