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Non-inositol 1,4,5-trisphosphate (IP3) receptor IP3-binding proteins.
Mackrill JJ. Mackrill JJ. Biochim Biophys Acta Mol Cell Res. 2023 Jun;1870(5):119470. doi: 10.1016/j.bbamcr.2023.119470. Epub 2023 Apr 1. Biochim Biophys Acta Mol Cell Res. 2023. PMID: 37011730 Free article.
To explore this possibility further, the Protein Data Bank was searched using the term "IP3". This resulted in the retrieval of 203 protein structures, the majority of which were members of the IP(3)R/ryanodine receptor superfamily of channels. ...
To explore this possibility further, the Protein Data Bank was searched using the term "IP3". This resulted in the retrieval of 203 p …
Ryanodine receptor calcium release channels in trophoblasts and their role in cell migration.
Zheng L, Lindsay A, McSweeney K, Aplin J, Forbes K, Smith S, Tunwell R, Mackrill JJ. Zheng L, et al. Among authors: mackrill jj. Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119139. doi: 10.1016/j.bbamcr.2021.119139. Epub 2021 Oct 6. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 34624436 Free article.
RyR1 and RyR3 proteins were detected in trophoblasts of human first trimester and term placental villi, along with the accessory proteins triadin and calsequestrin. ...
RyR1 and RyR3 proteins were detected in trophoblasts of human first trimester and term placental villi, along with the accessory prot …
Oxysterols modulate calcium signalling in the A7r5 aortic smooth muscle cell-line.
Hammoud Y, Rice T, Mackrill JJ. Hammoud Y, et al. Among authors: mackrill jj. Biochimie. 2013 Mar;95(3):568-77. doi: 10.1016/j.biochi.2012.08.003. Epub 2012 Sep 1. Biochimie. 2013. PMID: 22960205
These oxysterols also inhibited Ca(2+) transients in response to arginine vasopressin and bradykinin, and some but not all congeners ablated Ca(2+) signals triggered by platelet activating factor, the ryanodine receptor calcium channel agonist 4-choloro-meta-cresol, or thapsigarg …
These oxysterols also inhibited Ca(2+) transients in response to arginine vasopressin and bradykinin, and some but not all congeners ablated …
Oxysterols and calcium signal transduction.
Mackrill JJ. Mackrill JJ. Chem Phys Lipids. 2011 Sep;164(6):488-95. doi: 10.1016/j.chemphyslip.2011.04.001. Epub 2011 Apr 13. Chem Phys Lipids. 2011. PMID: 21513705 Review.
Furthermore, exposure of cells to oxysterols for periods of hours to days modulates Ca(2+) signal transduction, with these longer-term alterations in cellular Ca(2+) homeostasis potentially underlying pathological events within atherosclerotic lesions, such as hyporeactivi …
Furthermore, exposure of cells to oxysterols for periods of hours to days modulates Ca(2+) signal transduction, with these longer-term …
The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide.
Lordan S, O'Brien NM, Mackrill JJ. Lordan S, et al. Among authors: mackrill jj. J Biochem Mol Toxicol. 2009 Sep-Oct;23(5):324-32. doi: 10.1002/jbt.20295. J Biochem Mol Toxicol. 2009. PMID: 19827036
Moreover, dihydropyridine (DHP) binding sites identified with BODIPY-FLX-DHP were blocked following pretreatment with nifedipine, indicating that the influx of Ca(2+) occurred through L-type channels. However, following long-term incubation with 7beta-OH, elevated levels o …
Moreover, dihydropyridine (DHP) binding sites identified with BODIPY-FLX-DHP were blocked following pretreatment with nifedipine, indicating …