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Functional Validation of Candidate Genes Detected by Genomic Feature Models.
Rohde PD, Østergaard S, Kristensen TN, Sørensen P, Loeschcke V, Mackay TFC, Sarup P. Rohde PD, et al. Among authors: mackay tfc. G3 (Bethesda). 2018 May 4;8(5):1659-1668. doi: 10.1534/g3.118.200082. G3 (Bethesda). 2018. PMID: 29519937 Free PMC article.
In five of the seven candidate genes tested, reduced gene expression altered the phenotype. The ranking of genes within the predictive GO term was highly correlated with the magnitude of the phenotypic consequence of gene knockdown. ...
In five of the seven candidate genes tested, reduced gene expression altered the phenotype. The ranking of genes within the predictive GO …
Longevity GWAS Using the Drosophila Genetic Reference Panel.
Ivanov DK, Escott-Price V, Ziehm M, Magwire MM, Mackay TF, Partridge L, Thornton JM. Ivanov DK, et al. Among authors: mackay tf. J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1470-8. doi: 10.1093/gerona/glv047. Epub 2015 Apr 28. J Gerontol A Biol Sci Med Sci. 2015. PMID: 25922346 Free PMC article.
Gene Ontology analysis suggested that genes involved in carbohydrate metabolism are important for lifespan; including the InterPro term DUF227, which has been previously associated with lifespan determination. ...
Gene Ontology analysis suggested that genes involved in carbohydrate metabolism are important for lifespan; including the InterPro term …
Polygenic mutation in Drosophila melanogaster: Mapping spontaneous mutations affecting sensory bristle number.
Mackay TF, Lyman RF, Lawrence F. Mackay TF, et al. Genetics. 2005 Aug;170(4):1723-35. doi: 10.1534/genetics.104.032581. Epub 2005 Jun 8. Genetics. 2005. PMID: 15944368 Free PMC article.
Our ability to predict long-term responses to artificial and natural selection, and understand the mechanisms by which naturally occurring variation for quantitative traits is maintained, depends on detailed knowledge of the properties of spontaneous polygenic mutations, i …
Our ability to predict long-term responses to artificial and natural selection, and understand the mechanisms by which naturally occu …
Quantitative trait loci affecting natural variation in Drosophila longevity.
Geiger-Thornsberry GL, Mackay TF. Geiger-Thornsberry GL, et al. Among authors: mackay tf. Mech Ageing Dev. 2004 Mar;125(3):179-89. doi: 10.1016/j.mad.2003.12.008. Mech Ageing Dev. 2004. PMID: 15013662
Failure of the QTL alleles to complement the candidate gene mutation is indicated by a significant cross (mutant versus wild-type allele of the candidate gene) by inbred line interaction term from analysis of variance of life span. Failure to complement indicates a genetic …
Failure of the QTL alleles to complement the candidate gene mutation is indicated by a significant cross (mutant versus wild-type allele of …
Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster.
Long AD, Mullaney SL, Mackay TF, Langley CH. Long AD, et al. Among authors: mackay tf. Genetics. 1996 Dec;144(4):1497-510. doi: 10.1093/genetics/144.4.1497. Genetics. 1996. PMID: 8978039 Free PMC article.
Previously, we mapped quantitative trait loci (QTL) affecting response to short-term selection for abdominal bristle number to seven suggestive regions that contain loci involved in bristle development and/or that have adult bristle number mutant phenotypes, and are thus c …
Previously, we mapped quantitative trait loci (QTL) affecting response to short-term selection for abdominal bristle number to seven …
Polygenic mutation in Drosophila melanogaster: genetic interactions between selection lines and candidate quantitative trait loci.
Mackay TF, Fry JD. Mackay TF, et al. Genetics. 1996 Oct;144(2):671-88. doi: 10.1093/genetics/144.2.671. Genetics. 1996. PMID: 8889529 Free PMC article.
We have investigated genetic interactions between spontaneous mutations affecting abdominal and sternopleural bristle number that have accumulated in 12 long-term selection lines derived from an inbred strain, and mutations at 14 candidate bristle number quantitative trait …
We have investigated genetic interactions between spontaneous mutations affecting abdominal and sternopleural bristle number that have accum …
Polygenic mutation in Drosophila melanogaster: genetic analysis of selection lines.
Fry JD, deRonde KA, Mackay TF. Fry JD, et al. Among authors: mackay tf. Genetics. 1995 Mar;139(3):1293-307. doi: 10.1093/genetics/139.3.1293. Genetics. 1995. PMID: 7768439 Free PMC article.
We have conducted genetic analyses of 12 long-term selection lines of Drosophila melanogaster derived from a highly inbred base population, containing new mutations affecting abdominal and sternopleural bristle number. ...
We have conducted genetic analyses of 12 long-term selection lines of Drosophila melanogaster derived from a highly inbred base popul …