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Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits.
Farfara D, Feierman E, Richards A, Revenko AS, MacLeod RA, Norris EH, Strickland S. Farfara D, et al. Among authors: macleod ra. Glia. 2019 Jul;67(7):1359-1373. doi: 10.1002/glia.23611. Epub 2019 Mar 18. Glia. 2019. PMID: 30882931 Free PMC article.
In order to understand the effect of plasma C1INH on brain pathology via the vascular system, we knocked down circulating C1INH in wild-type (WT) mice using an antisense oligonucleotide (ASO), without affecting C1INH expression in peripheral immune cells or the brain, and examine …
In order to understand the effect of plasma C1INH on brain pathology via the vascular system, we knocked down circulating C1INH in wild-type …
The 50 Most Cited Articles in Rotator Cuff Repair Research.
Kraeutler MJ, Freedman KB, MacLeod RA, Schrock JB, Tjoumakaris FP, McCarty EC. Kraeutler MJ, et al. Among authors: macleod ra. Orthopedics. 2016 Nov 1;39(6):e1045-e1051. doi: 10.3928/01477447-20160714-01. Epub 2016 Jul 26. Orthopedics. 2016. PMID: 27458899 Review.
The ISI Web of Science (Thomson Reuters, Philadelphia, Pennsylvania) was used to conduct a search for the term rotator cuff repair. The 50 most cited articles were retrieved, and the following objective characteristics of each article were recorded: number of times cited, …
The ISI Web of Science (Thomson Reuters, Philadelphia, Pennsylvania) was used to conduct a search for the term rotator cuff repair. T …
Mechanisms underlying epigenetic and transcriptional heterogeneity in Chinese hamster ovary (CHO) cell lines.
Veith N, Ziehr H, MacLeod RA, Reamon-Buettner SM. Veith N, et al. Among authors: macleod ra. BMC Biotechnol. 2016 Jan 22;16:6. doi: 10.1186/s12896-016-0238-0. BMC Biotechnol. 2016. PMID: 26800878 Free PMC article.
BACKGROUND: Recombinant cell lines developed for therapeutic antibody production often suffer instability or lose recombinant protein expression during long-term culture. Heterogeneous gene expression among cell line subclones may result from epigenetic modifications of DN …
BACKGROUND: Recombinant cell lines developed for therapeutic antibody production often suffer instability or lose recombinant protein expres …
Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia.
Wang Q, Qiu H, Jiang H, Wu L, Dong S, Pan J, Wang W, Ping N, Xia J, Sun A, Wu D, Xue Y, Drexler HG, Macleod RA, Chen S. Wang Q, et al. Among authors: macleod ra. Haematologica. 2011 Dec;96(12):1808-14. doi: 10.3324/haematol.2011.043083. Epub 2011 Aug 31. Haematologica. 2011. PMID: 21880637 Free PMC article. Clinical Trial.
No differences in disease-free survival and overall survival between T-cell acute lymphoblastic leukemia patients with and without PHF6 mutations were observed in a short-term follow-up. CONCLUSIONS: Overall, these results indicate that, in T-cell acute lymphoblastic leuke …
No differences in disease-free survival and overall survival between T-cell acute lymphoblastic leukemia patients with and without PHF6 muta …
Chromosomal breakage correlates with delayed lethality in normal and ataxia telangiectasia cell lines treated with bleomycin.
MacLeod RA, Buchheim T, Kaufmann M, Drexler HG. MacLeod RA, et al. Mutat Res. 1996 Nov 11;372(1):33-42. doi: 10.1016/S0027-5107(96)00106-6. Mutat Res. 1996. PMID: 9003529
The following endpoints were studied: (1) the maximum (initial) yields of different classes of chromosomal aberrations (CA) produced in G2-phase; (2) the percentage distributions of cells within bins with different numbers of CA; (3) short-term (0-48 h) viability and proli …
The following endpoints were studied: (1) the maximum (initial) yields of different classes of chromosomal aberrations (CA) produced in G2-p …
Multiparameter approach in the identification of cross-contaminated leukemia cell lines.
Gignac SM, Steube K, Schleithoff L, Janssen JW, MacLeod RA, Quentmeier H, Drexler HG. Gignac SM, et al. Among authors: macleod ra. Leuk Lymphoma. 1993 Jul;10(4-5):359-68. doi: 10.3109/10428199309148561. Leuk Lymphoma. 1993. PMID: 8220135
Chromosome banding, DNA fingerprinting and bcr-abl genotyping suggested further evolution of these clones during long-term cultivation. Quality and identity control is an essential feature of cell culture technique. ...
Chromosome banding, DNA fingerprinting and bcr-abl genotyping suggested further evolution of these clones during long-term cultivatio …
Stability and comparative transport capacity of cells, mureinoplasts, and true protoplasts of a gram-negative bacterium.
De Voe IW, Thompson J, Costerton JW, MacLeod RA. De Voe IW, et al. Among authors: macleod ra. J Bacteriol. 1970 Mar;101(3):1014-26. doi: 10.1128/jb.101.3.1014-1026.1970. J Bacteriol. 1970. PMID: 4908775 Free PMC article.
The outer layers of the cell envelope of a pseudomonad of marine origin were removed by washing the cells in 0.5 m NaCl followed by suspension in 0.5 m sucrose. The term mureinoplast has been suggested for the rod-shaped forms which resulted from this treatment. ...
The outer layers of the cell envelope of a pseudomonad of marine origin were removed by washing the cells in 0.5 m NaCl followed by suspensi …